国家自然科学基金(s31100545)

作品数：3被引量：2H指数：1
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相关期刊：《Acta Biochimica et Biophysica Sinica》更多>>
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A novel small positive allosteric modulator of neuropeptide receptor PAC1-R exerts neuroprotective effects in MPTP mouse Parkinson's disease model
《Acta Biochimica et Biophysica Sinica》2022年第9期1349-1364,共16页Guangchun Fan Shang Chen Zhengxin Tao Huahua Zhang Rongjie Yu 
the grants from the National Natural Science Foundation of China(Nos.31100545 and 31670848);the Natural Science Foundation of Guangdong Province(Nos.2016A030313087 and 2022A1515011158).
As a neuropeptide pituitary adenylate cyclase-activating polypeptide(PACAP)-preferring receptor,PAC1-R mediates effective neuroprotective activity.Based on the finding that the antibiotic doxycycline(DOX)with clinical...
关键词：positive allosteric modulator PACAP receptor 1 DOXYCYCLINE computer virtual screening neuroprotective activity Parkinson's disease 
Positive allosteric regulation of PAC1-R up-regulates PAC1-R and its specific ligand PACAP被引量：1
《Acta Biochimica et Biophysica Sinica》2022年第5期657-672,共16页Guangchun Fan Zhengxin Tao Shang Chen Huahua Zhang Rongjie Yu 
supported by the grants from the National Natural Science Foundation of China(Nos.31100545 and 31670848);the Natural Science Foundation of Guangdong Province(Nos.2016A030313087 and 2022A1515011158).
PAC1-R is a recognized preferential receptor for the neuropeptide of pituitary adenylate cyclase-activating polypeptide(PACAP),which mediates neuroprotective and nerve regenerative activities of PACAP.In this study,we...
关键词：PACAP PAC1-R positive allosteric modulation nuclear translocation 
The allosteric modulation effects of doxycycline, minocycline, and their derivatives on the neuropeptide receptor PAC1-R被引量：2
《Acta Biochimica et Biophysica Sinica》2019年第6期627-637,共11页Suqin Song Like Wang Junfeng Li Xiaoling Huang Rongjie Yu 
This work was supported by the grants from the National Natural Science Foundation of China (Nos.31100545 and 31670848);the Natural Science Foundation of Guangdong Province (No.2016A030313087).
Class B G-protein coupled receptors (GPCR) PAC1-R is a neuropeptide pituitary adenylate cyclase activating polypeptide(PACAP)-preferring receptor that mediates the effective neuroprotective activity.Based on our previ...
关键词：pituitary ADENYLATE cyclase-activating polypeptide G-PROTEIN coupled RECEPTOR PAC1-R allosteric modulator DOXYCYCLINE MINOCYCLINE N-terminal extra cellular domain 
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