Acknowledgements This study was supported by the National High Technology Research and Development Program of China (863 Program, No. 2012AA020101), the National Natural Science Foundation of China (No. 81272358), the Foundation of National Clinical Research Center of Cancer (No. N14B10), and the Key Program of National Natural Science Foundation of China (No. 30930038).
Slit and Robo are considered tumor suppressors because they are frequently inactivated in various tumor tissue. These genes are closely correlated with CpG hypermethylation in their promoters. The Slit/Robo signaling ...