国家自然科学基金(21221003)

作品数:15被引量:18H指数:2
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相关作者:王柯敏何晓晓张小华陈金华刘剑波更多>>
相关机构:湖南大学长沙理工大学西北有色金属研究院湖南人文科技学院更多>>
相关期刊:《Science China Chemistry》《高等学校化学学报》《物理化学学报》《科学通报》更多>>
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Unveiling Cellular Internalization Dynamics of Single Gold Nanorods by Tracking Their Orientational and Translational Motions
《CCS Chemistry》2022年第4期1295-1304,共10页Dong Xu Yi Du Feng Ge Yan He Edward S.Yeung 
supported by the National Natural Science Foundation of China(grant nos.21127009,21221003,and 21425519);the Training Program for Excellent Young Innovators of Changsha(grant no.kq1905061);the Natural Science Foundation of Hunan Province,China(grant no.020RC3042).
Single nanoparticle tracking(SPT)is a unique and powerful tool to investigate the interaction between nanoparticles and cells,which is of considerable importance for nanotechnology applications in biomedical fields an...
关键词:orientation distribution pattern nanoparticle cellular internalization orientational and translational motion single nanoparticle tracking 
Reveal heterogeneous motion states in single nanoparticle trajectory using its own history
《Science China Chemistry》2021年第2期302-312,共11页Hansen Zhao Feng Ge Sichun Zhang Xinrong Zhang Yan He 
the National Natural Science Foundation of China(21425519,21221003)。
Single particle tracking(SPT)has long been utilized for investigation of complex system dynamics such as nanoparticle-cell interaction,however,the analysis of individual particle motions is always a difficult issue.Ex...
关键词:single particle tracking NANOPARTICLE machine learning 
Real-time observation of dynamic heterogeneity of gold nanorods on plasma membrane with darkfield microscopy被引量:1
《Science China Chemistry》2019年第8期1072-1081,共10页Feng Ge Jianfeng Xue Zonghua Wang Bin Xiong Yan He 
supported by the National Natural Science Foundation of China (21127009, 21425519, 21221003, 21475071, 21605045);the Tsinghua University Startup Fund, the Taishan Scholar Program of Shandong Province (ts201511027);the Natural Science Foundation of Shandong (2018GGX102030)
The plasma membrane possesses a complicated structure, on which the protein clusters are randomly but orderly distributed to maintain the regular morphology and function of cells. Investigating the detailed dynamic be...
关键词:single PARTICLE tracking GOLD NANORODS NANOPARTICLE cell interaction darkfield MICROSCOPY 
Background-free three-dimensional selective imaging of anisotropic plasmonic nanoparticles
《Nano Research》2017年第4期1423-1433,共11页Xiaodong Cheng Xuan Cao Bin Xiong Yan He Edward S. Yeung 
Acknowledgements This work was supported by the National Natural Sdence Foundation of China (Nos. 91027037, 21127009, 21425519 and 21221003), Hunan University 985 fund, Tsinghua University Startup fund, the Natural Science Foundation of Zhejiang Province (No. LY16B050006) and Wenzhou Medical University Setup fund (No. QTJ15022).
There is an increasing demand for advanced optical imaging techniques that can detect and resolve nanosize objects at a spatial resolution below the optical diffraction limit, especially in three-dimensional (3D) ce...
关键词:anisotropic nanopartide localized surface plasmon resonance (LSPR) scattering imaging polarization microscopy orientation-dependent localization microscopy three-dimensional (3D) imaging 
Recent progress in gold nanoparticle-based biosensing and cellular imaging被引量:3
《Science China Chemistry》2016年第7期783-793,共11页Haiyang Peng Hao Tang Jianhui Jiang 
supported by the National Natural Science Foundation of China (Nos. 21527810, 21190041, 21307029, and 21221003)
Gold nanoparticles(Au NPs) have been extensively used in optical biosensing and bioimaging due to the unique optical properties. Biological applications including biosensing and cellular imaging based on optical prope...
关键词:gold nanoparticle OPTICAL FUNCTIONALIZATION BIOSENSING cellular imaging 
A pH-responsive activatable aptamer probe for targeted cancer imaging based on i-motif-driven conformation alteration被引量:1
《Science China Chemistry》2016年第7期802-808,共7页Lv'an Yan Hui Shi Dinggeng He Xiaoxiao He Kemin Wang Fengzhou Xu 
supported by the Key Project of National Natural Science Foundation of China (21175039, 21322509, 21305035, 21190044, 21221003, 21305038, 2015JJ3044)
We present here a pH-responsive activatable aptamer probe for targeted cancer imaging based on i-motif-driven conformation alteration. This pH-responsive activatable aptamer probe is composed of two single-stranded DN...
关键词:APTAMER PH-RESPONSIVE activatable probe cancer cell imaging I-MOTIF tissue imaging 
交替加权四线性分解算法用于处理非五线性五维数阵
《中国科学:化学》2016年第4期401-408,共8页卿湘东 吴海龙 张喜华 李勇 谷惠文 文瑾 申湘忠 俞汝勤 
国家自然科学基金(编号:21175041,21221003);湖南人文科技学院引进人才启动项目(编号:8250139)资助
针对获得的非五线性五维数阵,采用一种先拓展后处理的思路,即将该数阵沿着不具有线性的一维铺展成四线性四维数阵,然后采用四维平行因子分析(4-PARAFAC)、交替加权残差约束四线性分解(AWRCQLD)和新发展的交替加权四线性分解(AWQLD)算法...
关键词:交替加权四线性分解 四维校正 非五线性五维数阵 平行因子分析 色谱 
Simultaneous determination of naphazoline and pyridoxine in eye drops using excitation–emission matrix fluorescence coupled with second-order calibration method based on alternating trilinear decomposition algorithm被引量:2
《Chinese Chemical Letters》2015年第12期1446-1449,共4页Hui Xia Hai-Long Wu Hui-Wen Gu Xiao-Li Yin Huan Fang Ru-Qin Yu 
the financial supports from the National Natural Science Foundation of China(No.21175041);the National Basic Research Program of China(No.2012CB910602);the Foundation for Innovative Research Groups of NSFC(No.21221003)
A novel method is developed for the direct determination of naphazoline hydrochloride(NAP) and pyridoxine hydrochloride(VB6) in commercial eye drops. By using excitation–emission matrix(EEM)fluorescence coupled...
关键词:calibration excitation satisfactory labeled interpolation pharmaceutical normalized alternating batch scatter 
双牺牲模板法制备一维管状Pt-Mn_3O_4-C复合物及其优越的甲醇电催化氧化性能(英文)被引量:1
《物理化学学报》2015年第5期927-932,共6页李丽 何小丽 覃涛 戴富涛 张小华 陈金华 
supported by the Program for Changjiang Scholars and Innovative Research Team in University,China(IRT1238);National Natural Science Foundation of China(21275041,21235002,J1210040);Foundation for Innovative Research Groups of National Natural Science Foundation of China(21221003);Hunan Provincial Natural Science Foundation,China(12JJ2010);Specialized Research Fund for the Doctoral Program of Higher Education,China(20110161110009)~~
通过双牺牲模板法合成了以一维管状Mn3O4-C为催化剂载体的新型Pt基电催化剂.催化剂的表面形貌、晶体结构及其组成分别采用透射电镜、X射线衍射仪、能量散射X射线光谱进行表征.通过循环伏安法对PtMn3O4-C复合物的电化学性能进行了测试....
关键词:PT纳米粒子 管式Mn3O4-C 电催化剂 甲醇电氧化 
Cell-SELEX-based aptamer-conjugated nanomaterials for cancer diagnosis and therapy被引量:2
《National Science Review》2015年第1期71-84,共14页Hong-Min Meng Ting Fu Xiao-Bing Zhang Weihong Tan 
supported by the National Key Scientiic Program of China(2011CB911000);the National Natural Science Foundation of China(21221003);the China National Instrumentation Program(2011YQ03012412)
Nucleic acid aptamers, which are generated by a novel technique called SELEX(systematic evolution of ligands by exponential enrichment), have recently atracted signiicant atention in the ield of early detection and tr...
关键词:APTAMER cell-SELEX NANOMATERIAL cancer cells cancer diagnosis and therapy 
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