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国家高技术研究发展计划(2012AA022703): 作品数：13被引量：30H指数：3; 导出分析报告; 相关作者：陈宝安程坚文颂何向锋王建红更多>>; 相关机构：东南大学南昌大学第二附属医院中国药科大学南通大学第二附属医院更多>>; 相关期刊：《Regenerative Biomaterials》《Science China Chemistry》《中国科技成果》《中国实验血液学杂志》更多>>; 相关主题：IN_VIVOMEDICINEFOOD_SECURITYCHEMISTRYAPPLICATIONS更多>>; 相关领域：医药卫生理学轻工技术与工程一般工业技术更多>>

针对生物标志物检测的低成本检测系统的研制: 《中国科技成果》2017年第13期9-10,共2页张伟; 国家863计划课题（2012AA022703）.; 课题目标：开发针对肿瘤生物标志物的超微量快速检测技术、早期诊断试剂盒和纳米检测器件，进而构建低成本、超微量、快速、准确检测的生物传感器，推动医学诊断技术向小型化、高通量方向发展，研发出拥有自主知识产权、有广泛市场前景...; 关键词：生物标志物检测系统低成本快速检测技术自主知识产权纳米生物创新能力诊断试剂盒

A flexible metal-organic framework with double interpenetration for highly selective CO_2 capture at room temperature被引量：1: 《Science China Chemistry》2016年第8期1051-1058,共8页Bingcong Zhou Haowen Yang Yan Deng Ming Liu Bin Liu Nongyue He Zhiyang Li; supported by the National Key Program for Developing Basic Research (2014CB744501);the National High Technology Research and Development Program of China (2012AA022703);the National Key Special Science Program (2013ZX10004103-002);the National Natural Science Foundation of China (61471168, 61527806, 61271056);the Special Projects in Jiangsu Province (BL2014094);the Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province [(2013) 448];the Talents Planning of Six Summit Fields of Jiangsu Province (2013-WSN-056);Tianjin Medical University General Hospital Funding (ZYYFY2015029);China Postdoctoral Science Foundation funded project (2015T80487);Natural Science Foundation of Jiangsu Province (BK20140900);the Open Project of State Key Laboratory of Bioelectronics (2014HX12); MicroRNAs （miRNAs） are small non-coding RNAs that regulate gene expression at the post-transcriptional level, and their aberrant expression occurs during the development of malignant diseases. Recently, miRNAs have ...; 关键词：MicroRNA QUANTITATION magnetic bead CHEMILUMINESCENCE liver cancer

Simultaneous extraction of DNA and RNA from Escherichia coli BL 21 based on silica-coated magnetic nanoparticles被引量：7: 《Science China Chemistry》2015年第11期1774-1778,共5页Jiuhai Wang Zeeshan Ali Nianyue Wang Wenbiao Liang Hongna Liu Fu Li Haowen Yang Lei He Libo Nie Nongyue He Zhiyang Li; supported by the National Basic Research Program of China(2014CB744501);the National High Technology Research and Development Program of China(2012AA022703);the National Key Special Science Program(2013ZX10004103-002);the National Natural Science Foundation of China(61201033,21205013,61271056,61527806);Projects of Development of Science and Medical Technology(201208038);Projects of Health Ministry of Nanjing(ZKX12038);the Clinical Science and Technology Special Projects in Jiangsu Province(BL2012067,BL2014094);the Talents Planning of Six Summit Fields of Jiangsu Province(2013-WSN-056);China Postdoctoral Science Foundation Funded Project(2014M551491,2015T80487);Jiangsu Planned Projects for Postdoctoral Research Funds(1302007A);the Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province; The extraction of nucleic acid is recognized as one of the most essential steps in molecular biology for initiating other downstream applications such as sequencing, amplification, hybridization, and cloning. Many com...; 关键词：nucleic acids simultaneous extraction magnetic nanoparticles （MNPs） BACTERIA

体外光化学疗法治疗慢性移植物抗宿主病的研究进展被引量：1: 《中国实验血液学杂志》2015年第4期1203-1207,共5页陈润哲陈宝安程坚; 国家自然科学基金(81170492;81370673);国家973科技计划项目(2010CB732404);国家863科技计划项目(2012AA022703);江苏省科技厅医学重点项目(BL2014078);江苏省医学重点学科(2011-12); 慢性移植物抗宿主病(c GVHD)是异基因造血干细胞移植后的主要并发症及导致患者死亡的主要原因之一。体外光化学疗法(extracorporeal photochemotherapy,ECP)已成为治疗c GVHD的一种有效手段,它是用长波紫外线照射患者的单个核细胞与光敏...; 关键词：体外光化学疗法异基因造血干细胞移植慢性移植物抗宿主病

In vivo rapid fluorescence imaging of Alzheimer's disease through accurate target bio-marking of zinc gluconate被引量：3: 《Science Bulletin》2015年第16期1465-1467,共3页Lanmei Lai Chunqiu Zhao Meina Su Jing Ye Hui Jiang Xuemei Wang; supported by the National Natural Science Foundation of China(81325011);the National High Technology Research and Development Program of China(2015AA020502,2012AA022703);the Major Science and Technology Project of Suzhou(ZXY2012028); Alzheimer's disease(AD) is a progressive and age-related irreversible neurodegenerative disease. When AD occurs, the relevant amount of zinc ions in brain considerably changes. In this contribution, we have explored t...; 关键词：Zinc gluconate Fluorescence bio-imaging Alzheimer＇s disease

CFSE荧光负染法检测RAW264.7小鼠单核巨噬细胞白血病细胞摄取超顺磁性氧化铁纳米粒子: 《中国实验血液学杂志》2015年第4期1168-1172,共5页何向锋杨俐萍陈宝安王建红文颂施文徐薇薇凌国杰; 国家重点基础研究发展计划(973计划)子课题(2010CB732404);国家高技术研究发展计划(863计划)子课题(2012AA022703);国家自然科学基金(81170492;81370673;81401460);江苏省科技厅医学重点项目(BL2014078);中国博士后科学基金项目(2013M530227);江苏省博士后科研资助计划项目(1301099C);南通市市级科技计划项目(B K2012067); 目的:探讨CFSE荧光负染法用于检测RAW264.7小鼠单核巨噬细胞白血病细胞吞噬超顺磁性氧化铁纳米粒子(super paramaganetic iron oxide nanoparticles,SPIO)的可行性及其荧光特征。方法:体外对RAW264.7细胞进行SPIO的标记,然后分别采用普...; 关键词：CFSE荧光负染法 RAW264.7小鼠单核巨噬细胞白血病细胞超顺磁性氧化铁纳米粒子

藤黄酸联合柔红霉素对白血病耐药细胞株K562/A02孕烷X受体表达的影响（英文）被引量：4: 《中国实验血液学杂志》2015年第4期956-961,共6页朱晗陈宝安蔡晓辉王飞高冲程坚张孝平戴璐夏国华傅蓉郭青龙; 江苏医学重点学科(2012-12)资助;国家自然科学基金面上项目(81170492);国家自然科学基金面上项目(81370673);国家重点基础研究发展计划(973计划)子课题(2010CB732404);国家高技术研究发展计划(863计划)子课题(2012AA022703); 目的:研究恶性血液病细胞株孕烷X受体(Pregnane X receptor)的表达水平;探讨藤黄酸(Gambogic acid,GA)对K562/A02耐药细胞株的耐药逆转作用及其机制。方法:应用Real-time PCR法检测多个恶性血液病细胞株中PXR的表达;采用MTT法检测K562/...; 关键词：孕烷X受体藤黄酸柔红霉素多药耐药 K562/A02细胞

Applications of aptamers for chemistry analysis, medicine and food security被引量：8: 《Science China Chemistry》2015年第7期1122-1130,共9页Rongrong Huang Zhijiang Xi Nongyue He; supported by the 863 Project(2012AA022703,2015AA020502);the National Natural Science Foundation of China(61271056); Since aptamer and its in vitro selection process called SELEX were independently described by Ellington and Gold in 1990, extensive research has been undertaken and numerous isolated aptamers for various targets have ...; 关键词：aptamers APPLICATIONS chemistry analysis MEDICINE food security

小鼠盲肠系膜三角原位种植结肠癌模型的构建与评价被引量：1: 《中华肿瘤杂志》2015年第6期418-421,共4页何向锋施文文颂孙永强凌国杰沈康彭春雷陈宝安王建红; 国家重点基础研究发展计划（973计划）子课题（2010CB732404）;国家高技术研究发展计划（863计划）子课题（2012AA022703）;国家自然科学基金（81170492、81370673、81401460）;江苏省科技厅医学重点项目（BL2014078）;中国博士后科学基金项目（2013M530227）;江苏省博士后科研资助计划项目（1301099C）;南通市市级科技计划项目（BK2012067、HS2013030）;南通市卫生局青年基金项目（WQ2014012）; 目的：探讨经盲肠系膜三角注射肿瘤细胞悬液制备小鼠结肠癌原位种植模型的可行性。方法手术暴露小鼠盲肠，将小鼠结肠腺癌CT26． WT细胞接种于盲肠系膜三角，建立小鼠结肠癌原位种植模型。结果20只BAL B／c小鼠经盲肠系膜三角注射肿瘤...; 关键词：结肠肿瘤肿瘤转移肝小鼠模型

Drug carriers based on highly protein-resistant materials for prolonged in vivo circulation time被引量：2: 《Regenerative Biomaterials》2015年第2期125-133,共9页Ruiyuan Liu Yan Li Zhenzhong Zhang Xin Zhang; This work was supported by the National Natural Science Foundation of China(21304099,51203162,51103159,51373177);the National High Technology Research and Development Program(2014AA020708,2012AA022703,2012AA020804);the Instrument Developing Project of the Chinese Academy of Sciences(YZ201253,YZ201313);the Open Funding Project of the National Key Laboratory of Biochemical Engineering(Y22504A169);the‘Strategic Priority Research Program’of the Chinese Academy of Sciences(XDA09030301-3);Beijing Natural Science Foundation(Z141100000214010).; Long-circulating drug carriers are highly desirable in drug delivery system.However,nonspecific protein adsorption leaves a great challenge in drug delivery of intravenous administration and significantly affects both...; 关键词：long circulation nonspecific protein adsorption materials drug carrier surface modification

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