国家重点基础研究发展计划(G199805110G19980511152004CB518907)

作品数：4被引量：57H指数：4
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Cucurbitacin I inhibits STAT3, but enhances STAT1 signaling in human cancer cells in vitro through disrupting actin filaments被引量：9
《Acta Pharmacologica Sinica》2018年第3期425-437,共13页Hui GUO Shan KUANG Qiao-ling SONG Man LIU Xiao-xiao SUN Qiang YU 
This work was supported by the China Ministry of Science and Technology Key New Drug Creation and Manufacturing Program （No 2014ZX9102001002 to Qiang YU）, the China National Key Basic Research Program （No 2013CB9i0900 to Qiang YU）, and the National Natural Science Foundation of China （No 81373447 and 81673465 to Qiang YU）.
STAT1 and STAT3 are two important members of the STAT （signal transducers and activators of transcription） protein family and play opposing roles in regulating cancer cell growth. Suppressing STAT3 and/or enhancing ...
关键词：cucurbitacin I cancer cells STAT1 STAT3 ACTIN phosphorylation 
Class I histone deacetylases are major histone decrotonylases： evidence for critical and broad function of histone crotonylation in transcription被引量：24
《Cell Research》2017年第7期898-915,共18页Wei Wei Xiaoguang Liu Jiwei Chen Shennan Gao Lu Lu Huifang Zhang Guangjin Ding Zhiqiang Wang Zhongzhou Chen Tieliu Shi Jiwen Li Jianjun Yu Jiemin Wong 
We thank members of Wong＇s laboratory for valuable discussion.We thank Dr Cheng-Ming Chiang （UT Southwestern） for critical reading of the manuscript. This study is supported by grants from the National Science and Technology Major Project ＂Key New Drug Creation and Manufacturing Program＂ of China （2014ZX09507002- 005 to JW）, the Ministry of Science and Technology of China （2015CB910402 to JW）, the National Natural Science Foundation of China （81530078 and 31571325 to JW）, the Science and Tech- nology Commission of Shanghai Municipality （14XD1401700 and 11DZ2260300 to JW）.
Recent studies on enzymes and reader proteins for histone crotonylation support a function of histone crotonyla- tion in transcription. However, the enzyme（s） responsible for histone decrotonylation （HDCR） remains...
关键词：class I histone deacetylases histone decrotonylation histone deacetylation histone deacylation HDAC SIRT 
Pharmacokinetics and disposition of monoterpene glycosides derived from Paeonia lactiflora roots （Chishao） after intravenous dosing of antiseptic XueBiJing injection in human subjects and rats被引量：19
《Acta Pharmacologica Sinica》2016年第4期530-544,共15页Chen CHENG Jia-zhen LIN Li LI Jun-ling YANG Wei-wei JIA Yu-hong HUANG Fei-fei DU Feng-qing WANG Mei-juan LI Yan-fen LI Fang XU Na-ting ZHANG Olajide E. OLALEYE Yan SUN Jian LI Chang-hai SUN Gui-ping ZHANG Chuan LI 
Acknowledgements This work was funded by grants from the National Science ＆ Technology Major Project of China ＇Key New Drug Creation and Manufacturing Program＇ （2009ZX09304-002 and 2011ZX09201-201-23）, the National Science Foundation of China for Distinguished Young Scholars （30925044）, the National Basic Research Program of China （2012CB518403）, the National Natural Science Foundation of China （81503345）, and the China Postdoctoral Science Foundation funded project （2014M560169）.
Aim： Monoterpene glycosides derived from Paeonia lactiflora roots （Chishao） are believed to be pharmacologically important for the antiseptic herbal injection XueBiJing. This study was designed to characterize the ...
关键词：herbal injection XUEBIJING Paeonia lactiflora roots Chishao monoterpene glycosides paeoniflorin PHARMACOKINETICS DISPOSITION 
Retrospect and prospect of active principles from Chinese herbs in the treatment of dementia被引量：5
《Acta Pharmacologica Sinica》2010年第6期649-664,共16页Ying WANG Lu-qi HUANG Xi-can TANG Hai-yan ZHANG 
The work was supported in part by the Ministry of Science and Technology of China （G199805110, G1998051115, No 2004CB518907）, National Science ＆ Technology Major Project ＂Key New Drug Creation and Manufacturing Program＂ China （Number： 2009ZX09103-063）, and the National Natural Science Foundation of China （39170860, 39770846, 3001161954, 30123005, 30271494, 30572169, and 30801402）. The authors are grateful to Dr Xiao-qiu XIAO, Dr Jin ZHOU, Dr Han YAN, Dr Zhi-fei WANG, Dr Xin GAO, and others for their contributions to Hup A, ZT-1 or S-52 studies.
With an ageing population, dementia has become one of the world＇s primary health challenges. However, existing remedies offer limited benefits with certain side effects, which has prompted researchers to seek complem...
关键词：DEMENTIA traditional Chinese medicine （TCM） active principle NEUROPROTECTION 
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