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国家自然科学基金(81370470): 作品数：10被引量：70H指数：5; 导出分析报告; 相关作者：乐卫东李崧邱红艳王英杨娑娑更多>>; 相关机构：大连医科大学附属第一医院上海交通大学医学院附属瑞金医院大连医科大学更多>>; 相关期刊：《Translational Neurodegeneration》《转化医学杂志》《Neuroscience Bulletin》《医学与哲学（B）》更多>>; 相关主题：BIOMARKERINFLAMMATIONGENESISTHE_PATHROLE更多>>; 相关领域：医药卫生更多>>

Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model被引量：10: 《Translational Neurodegeneration》2018年第1期378-391,共14页Jingjing Zhang Yufei Liu Xinyao Liu Song Li Cheng Cheng Sheng Chen Weidong Le; This work was supported by funding from the National Natural Sciences Foundation of China(NSFC 81430021 and 81370470);the Program for Liaoning Innovative Research Team in University(LT2015009);Liaoning Science and Technology Project(2015225008).; Background:Neuron-microglia communication plays a crucial role in the motor neurons(MNs)death in amyotrophic lateral sclerosis(ALS).Neurons can express chemokine(C-X3-C motif)ligand 1(CX3CL1),which mediates microglial...; 关键词：ALS CX3CL1/CX3CR1 AXIS MICROGLIAL activation SOD1^(G93A) mice

学然后知不足——美国临床研究体会与思索被引量：4: 《医学与哲学（B）》2017年第11期93-95,共3页杨娑娑乐卫东; 2014年国家自然科学基金项目(81430021);2013年国家自然科学基金项目(81370470); 随着中国医疗事业的发展,临床研究越来越受到重视,因为中国有着丰富的临床研究资源,庞大的受试群体,如果能很好地利用这些资源,会大大提升中国的临床研究水平,但中国目前的临床研究与美国等国家完善的临床研究体系还具有一定的差距,国...; 关键词：临床研究研究团队研究流程

Biomarker Discovery in Parkinson's Disease:Present Challenges and Future Opportunities被引量：5: 《Neuroscience Bulletin》2017年第5期481-482,共2页Song Li Weidong Le; supported by the National Natural Science Foundation of China (81430021 and 81370470); Parkinson＇s disease （PD） is the second most common neurodegenerative disorder affecting more than 1% of the older population. Histopathologically, PD is characterized by a severe loss of dopaminergic neurons in the...; 关键词：PD In Biomarker Discovery in Parkinson’s Disease Present Challenges and Future Opportunities

Can Biomarkers Help the Early Diagnosis of Parkinson's Disease?被引量：2: 《Neuroscience Bulletin》2017年第5期535-542,共8页Weidong Le Jie Dong Song Li Amos D. Korczyn; supported by grants from the National Natural Science Foundation of China (81430021 and 81370470);the Program for Liaoning Provincial Innovative Research Team in Universities (LT2015009);the Liaoning Provincial Science and Technology Project (2015225008);a Research Project of Dalian Science and Technology (2014E14SF175) of Liaoning Province, China; Parkinson＇s disease （PD） is a complex neurode- generative disease with progressive loss of dopamine neurons. PD patients usually manifest a series of motor and non-motor symptoms. In order to provide better early d...; 关键词：Parkinson＇s disease· Biomarker Early diag-nosis - Molecular imaging Biochemical markers

Tiny But Mighty:Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson's Disease被引量：7: 《Neuroscience Bulletin》2017年第5期543-551,共9页Ying Wang Zhaofei Yang Weidong Le; supported by the National Natural Science Foundation of China (81430021 and 81370470); Parkinson＇s disease （PD） is the second most common age-related neurodegenerative disorder after Alzheimer＇s disease. To date, the clinical diagnosis of PD is primarily based on the late onset of motor impairments....; 关键词：Parkinson＇s disease ·MicroRNA·Biomarker·Diagnosis

线粒体自噬参与帕金森病发病机制的研究进展被引量：4: 《中华临床医师杂志（电子版）》2015年第21期98-104,共7页王英张强乐卫东; 国家自然科学基金重点项目(81430021);国家自然科学基金面上项目(81370470); 帕金森病是中老年人常见的中枢神经系统退行性疾病,近年的研究表明线粒体自噬是帕金森病的发病机制之一。目前已知帕金森病相关基因PINK1、PARKIN、SNCA、DJ-1、LRRK2以及ATP13A2和GBA均参与线粒体自噬的调节。其中PINK1参与线粒体代谢...; 关键词：Α突触核蛋白线粒体线粒体自噬帕金森病帕金森病相关基因

慢性睡眠剥夺对小鼠学习记忆及神经元自噬和凋亡的影响被引量：13: 《中华神经科杂志》2015年第7期564-569,共6页邱红艳李崧乐卫东; 国家自然科学基金重点项目（81430021）;国家自然科学基金面上项目（81370470）; 目的通过建立小鼠慢性睡眠剥夺模型,观察长期睡眠剥夺对小鼠学习记忆以及对神经元细胞自噬和凋亡的影响.方法 C57BL/6小鼠20只,应用随机数字表进行随机分组,睡眠剥夺组和对照组各10只.采用改良的多平台法对睡眠剥夺组小鼠建立慢性睡眠...; 关键词：睡眠剥夺神经元自噬细胞凋亡记忆障碍疾病模型动物

Role of autophagy in the pathogenesis of multiple sclerosis被引量：21: 《Neuroscience Bulletin》2015年第4期435-444,共10页Peizhou Liang Weidong Le; supported by a grant from the National Natural Science Foundation of China (81430021 and 81370470);China Postdoctoral Science Foundation (2014M551465);the Collaborative Innovation Center for Brain Science; Autophagy plays an important role in maintaining the cellular homeostasis. One of its functions is to degrade unnecessary organelles and proteins for energy recycling or amino-acids for cell survival. Ablation of auto...; 关键词：AUTOPHAGY multiple sclerosis neuro-inflammation

转化医学在阿尔茨海默病中应用研究的最新进展: 《转化医学杂志》2014年第1期1-5,共5页崔艳华乐卫东; 国家自然科学基金项目(81370470); 阿尔茨海默病的发病原因及发病机制至今尚未明确,本文总结近1年来阿尔茨海默病转化医学研究的突破性进展,从阿尔茨海默病的病因、发病机制、检测方法及靶向治疗等方面作一简要综述。; 关键词：阿尔茨海默病转化医学

Hyposmia: a possible biomarker of Parkinson's disease被引量：7: 《Neuroscience Bulletin》2014年第1期134-140,共7页Qian Xiao Sheng Chen Weidong Le; supported by grants from the National Natural Science Foundation of China(81370470 and 81171201);National Basic Research Development Program of China 2011CB510003); Hyposmia, identified as reduced sensitivity to odor, is a common non-motor symptom of Parkinson＇s disease （PD） that antedates the typical motor symptoms by several years. It occurs in -90% of early-stage cases of P...; 关键词：HYPOSMIA Parkinson＇s disease OLFACTION BIOMARKER

国家自然科学基金(81370470)