MICROGLIAL

作品数：137被引量：348H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：庄丽华谭文莉龚志刚詹松华杨烁慧更多>>
相关机构：上海交通大学医学院附属瑞金医院上海中医药大学附属曙光医院更多>>
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相关基金：国家自然科学基金广东省自然科学基金中国博士后科学基金国家重点基础研究发展计划更多>>
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Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist
《Neural Regeneration Research》2025年第10期2895-2897,共3页Nicolas Hugues Yu Luo 
supported by NIH grants(R01NS125074,R01AG083164,and R21NS127177)(to YL).
Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS)...
关键词：FIGURE signature CRITICAL 
High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury
《Neural Regeneration Research》2025年第9期2611-2623,共13页Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu 
supported by research grants from the Ningbo Science and Technology Plan Project,No.2022Z143hezuo(to BL);the National Natural Science Foundation of China,No.82201520(to XD)。
Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently understood.As potent anti-i...
关键词：apoptosis BV2 microglia DEXAMETHASONE glucocorticoid receptor GLUCOCORTICOIDS innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury 
Neuroinflammation revisited through the microglial lens
《Neural Regeneration Research》2025年第7期1989-1990,共2页Renato Socodato João B.Relvas 
funded by Portuguese funds through FCT——Funda??o para a Ciência e a Tecnologia/Ministério da Ciência,Tecnologia e Ensino Superior in the framework of the project PTDC/MEDNEU/1677/2021(to JBR)。
Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune system.This exploration is particularly significant in understanding micro...
关键词：INFLAMMATION simplified ACTIVATION 
Microglial dysfunction and genetic risk for neurodegenerative disease
《Neural Regeneration Research》2025年第5期1401-1402,共2页Debra S.MacDonald Jay Penney 
supported by a Canada Research Chair award to JP。
Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations age.While tremendous progress has been made,our understanding of the mechanisms that underlie...
关键词：DEGENERATIVE DISEASES 
Aging-related inflammatory and metabolic disorder in the novel mutation of colony-stimulating factor-1 receptor(csf1r)^(P853T/+)in CsF1R-microglial encephalopathy
《Genes & Diseases》2025年第2期45-47,共3页Xiaohong Wang Yanli Wang Tianlin Jiang Jiwei Jiang Linlin Wang Shiyi Yang Mengfan Sun Yuan Zhang Ziyan Jia Wenyi Li Qiwei Ren Cuicui Zhang Jianjian Liu Yinwei Zhu Min Zhao Shirui Jiang Huiying Zhang Jinglong Chen Jun Xu 
supported by the National Natural Science Foundation of China (No.82071187,81870821,81501135,and 81471215);the National Key Research and Development Program of China (No.2021YFC2500100,2021YFC2500103);the Beijing Youth Talent Team Support Program (China) (No.2018000021223TD08);Science and Technology Program of Guangzhou (China) (No.202201020343).
CSF1R-microglial encephalopathy(CME)is a rare dementia with rapid development of cognitive impairment.The main clinical features of CME are progressive cognitive impairment,motor dysfunction,and neuropsychiatric sympt...
关键词：ENCEPHALOPATHY DEGENERATION IMPAIRMENT 
Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming
《Neural Regeneration Research》2025年第4期1178-1191,共14页Wanxian Luo Chuanhui Xu Linxi Li Yunxiang Ji Yezhong Wang Yingjia Li Yongyi Ye 
supported by the National Natural Science Foundation of China,No.82101327(to YY);President Foundation of Nanfang Hospital,Southern Medical University,No.2020A001(to WL);Guangdong Basic and Applied Basic Research Foundation,Nos.2019A1515110150,2022A1515012362(both to YY);Guangzhou Science and Technology Project,No.202201020111(to YY).
Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s disease.Na...
关键词：metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases NEUROINFLAMMATION oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry 
Inhibition of the microglial voltage-gated proton channel 1 channel ameliorates diabetes-associated cognitive dysfunction by regulating axon demyelination
《World Journal of Psychiatry》2025年第3期288-301,共14页Chun-Yu Li Shu-Jun Zhang Jia-Lu Xu Yan Yang Zhi-Xuan Zeng De-Lin Ma 
Supported by the National Natural Science Foundation of China,No.82300894.
BACKGROUND Diabetes is associated with increased cognitive decline and dementia due to the loss of myelinated nerve fiber function,which is linked to oligodendrocyte dysfunction.The voltage-gated proton channel 1(Hv1)...
关键词：Diabetes Cognitive dysfunction Voltage-gated proton channel 1 Neuroinflammation Myelin regeneration 
Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model
《Neural Regeneration Research》2025年第3期858-872,共15页Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai Huang Jia Wang Tao You 
supported by the Natural Science Research Project of Anhui Province University, No.2023AH040394 (to TY);Hefei Comprehensive National Science Center Leading Medicine and Frontier Technology Research Institute Project, No.2023IHM01073 (to TY);the Natural Science Foundation of Anhui Province, Nos.2308085QH258 (to JW), 2008085MH246 (to TY)。
Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PT...
关键词：apoptosis GLYCOLYSIS inflammatory response MICROGLIA neurons POLARIZATION spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2 
Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses
《Traditional Medicine Research》2025年第2期55-64,共10页Jin-Fang Wu Yi-Sheng Chen Yu-Chun Xie 
Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditio...
关键词：single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity 
Butyrate attenuates sympathetic activation in rats with chronic heart failure by inhibiting microglial inflammation in the paraventricular nucleus
《Acta Biochimica et Biophysica Sinica》2024年第12期1823-1832,共10页Chang Liu Hao Yu Hongyi Xia Ziwei Wang Bolin Li Hongmei Xue Sheng Jin Lin Xiao Yuming Wu Qi Guo 
supported by the grants from the Science Research Project of Hebei Education Department(No.ZD2021076)to Q.G.;the Scientific Research Foundation of Hebei Province for the Returned Overseas Chinese Scholars(No.C20220343)to Q.G.;the Youth Top Talent Program Foundation of Hebei Province of China to Q.G.,and the National Natural Science Foundation of China(No.32271155)to Y.W.
Sympathetic activation is a hallmark of heart failure and the underlying mechanism remains elusive.Butyrate is generated by gut microbiota and influences numerous physiological and pathological processes in the host.T...
关键词：heart failure paraventricular nucleus sympathetic nerve activity MICROGLIA INFLAMMATION 
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