MICROGLIAL

作品数：149被引量：353H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：庄丽华谭文莉龚志刚詹松华杨烁慧更多>>
相关机构：上海交通大学医学院附属瑞金医院上海中医药大学附属曙光医院更多>>
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相关基金：国家自然科学基金广东省自然科学基金中国博士后科学基金国家重点基础研究发展计划更多>>
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FIREproof:Intricacies of microglial biology
《Neural Regeneration Research》2026年第2期663-664,共2页Wei Cao 
funded by NIH grants HL154720-03S1,AG057587,AG074283,DK122708-03S1,BrightFocus ADR A20183775,and Brown Foundation 2020 Healthy Aging Initiative(to WC).
Microglia are the macrophages that populate the brain parenchyma.Research in the past decades has identified them as both essential guardians of the brain and significant contributors to various neurological diseases....
关键词：neurological diseases facilitating neurogenesis debris removal central nervous systemincluding NEUROGENESIS MYELINATION synapse pruning brain 
Microglial intervention in ischemic stroke:Roles and intervention strategies
《Neural Regeneration Research》2026年第2期443-454,共12页Cuiling Ji Lixinbei Sheng Kaijun Han Ping Yuan Wei Li Lu Chen Yongyue Gao 
supported by the National Natural Science Foundation of China,82471345(to LC);the Key Research and Development Program for Social Development by the Jiangsu Provincial Department of Science and Technology.No.BE2022668(to LC).
Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a...
关键词：blood-brain barrier ischemic stroke MICROGLIA nerve regeneration NEUROINFLAMMATION NEUROPROTECTION oxidative stress polarization signaling pathways therapeutic strategies 
Microglial polarization pathways and therapeutic drugs targeting activated microglia in traumatic brain injury
《Neural Regeneration Research》2026年第1期39-56,共18页Liping Shi Shuyi Liu Jialing Chen Hong Wang Zhengbo Wang 
supported by the Natural Science Foundation of Yunnan Province,No.202401AS070086(to ZW);the National Key Research and Development Program of China,No.2018YFA0801403(to ZW);Yunnan Science and Technology Talent and Platform Plan,No.202105AC160041(to ZW);the Natural Science Foundation of China,No.31960120(to ZW)。
Traumatic brain injury can be categorized into primary and secondary injuries.Secondary injuries are the main cause of disability following traumatic brain injury,which involves a complex multicellular cascade.Microgl...
关键词：animal model anti-inflammatory drug cell replacement strategy central nervous system mesenchymal stem cell MICROGLIA NEUROINFLAMMATION non-human primate signaling pathway traumatic brain injury 
Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist
《Neural Regeneration Research》2025年第10期2895-2897,共3页Nicolas Hugues Yu Luo 
supported by NIH grants(R01NS125074,R01AG083164,and R21NS127177)(to YL).
Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS)...
关键词：FIGURE signature CRITICAL 
High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury
《Neural Regeneration Research》2025年第9期2611-2623,共13页Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu 
supported by research grants from the Ningbo Science and Technology Plan Project,No.2022Z143hezuo(to BL);the National Natural Science Foundation of China,No.82201520(to XD)。
Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently understood.As potent anti-i...
关键词：apoptosis BV2 microglia DEXAMETHASONE glucocorticoid receptor GLUCOCORTICOIDS innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury 
Neuroinflammation revisited through the microglial lens
《Neural Regeneration Research》2025年第7期1989-1990,共2页Renato Socodato João B.Relvas 
funded by Portuguese funds through FCT——Funda??o para a Ciência e a Tecnologia/Ministério da Ciência,Tecnologia e Ensino Superior in the framework of the project PTDC/MEDNEU/1677/2021(to JBR)。
Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune system.This exploration is particularly significant in understanding micro...
关键词：INFLAMMATION simplified ACTIVATION 
Microglial dysfunction and genetic risk for neurodegenerative disease
《Neural Regeneration Research》2025年第5期1401-1402,共2页Debra S.MacDonald Jay Penney 
supported by a Canada Research Chair award to JP。
Neurodegenerative disorders such as Alzheimer's and Parkinson's diseases a re increasing in prevalence as world populations age.While tremendous progress has been made,our understanding of the mechanisms that underlie...
关键词：DEGENERATIVE DISEASES 
Aucubin mitigates the elevation of microglial aerobic glycolysis and inflammation in diabetic neuropathic pain via aldose reductase
《World Journal of Diabetes》2025年第5期346-362,共17页Xue-Zhen Zheng Hong-Yan Yu Ye-Ru Chen Jian-Sheng Fang 
Supported by National Natural Science Foundation of China,No.82001424.
BACKGROUND Treatment of diabetic neuropathy is often limited by side effects.Aucubin,an iridoid glycoside derived from natural plants,exhibits notable anti-inflammatory and antioxidant properties.AIM To investigate th...
关键词：Diabetic neuropathic pain AUCUBIN GLYCOLYSIS Aldose reductase MICROGLIA 
Aging-related inflammatory and metabolic disorder in the novel mutation of colony-stimulating factor-1 receptor(csf1r)^(P853T/+)in CsF1R-microglial encephalopathy
《Genes & Diseases》2025年第2期45-47,共3页Xiaohong Wang Yanli Wang Tianlin Jiang Jiwei Jiang Linlin Wang Shiyi Yang Mengfan Sun Yuan Zhang Ziyan Jia Wenyi Li Qiwei Ren Cuicui Zhang Jianjian Liu Yinwei Zhu Min Zhao Shirui Jiang Huiying Zhang Jinglong Chen Jun Xu 
supported by the National Natural Science Foundation of China (No.82071187,81870821,81501135,and 81471215);the National Key Research and Development Program of China (No.2021YFC2500100,2021YFC2500103);the Beijing Youth Talent Team Support Program (China) (No.2018000021223TD08);Science and Technology Program of Guangzhou (China) (No.202201020343).
CSF1R-microglial encephalopathy(CME)is a rare dementia with rapid development of cognitive impairment.The main clinical features of CME are progressive cognitive impairment,motor dysfunction,and neuropsychiatric sympt...
关键词：ENCEPHALOPATHY DEGENERATION IMPAIRMENT 
Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming
《Neural Regeneration Research》2025年第4期1178-1191,共14页Wanxian Luo Chuanhui Xu Linxi Li Yunxiang Ji Yezhong Wang Yingjia Li Yongyi Ye 
supported by the National Natural Science Foundation of China,No.82101327(to YY);President Foundation of Nanfang Hospital,Southern Medical University,No.2020A001(to WL);Guangdong Basic and Applied Basic Research Foundation,Nos.2019A1515110150,2022A1515012362(both to YY);Guangzhou Science and Technology Project,No.202201020111(to YY).
Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s disease.Na...
关键词：metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases NEUROINFLAMMATION oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry 
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