国家重点基础研究发展计划(2010CB833701)

作品数：5被引量：6H指数：2
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相关作者：徐涛章永登刘贝吴政星俞勇更多>>
相关机构：华中科技大学中国科学院更多>>
相关期刊：《Science China(Life Sciences)》《生物化学与生物物理进展》《Protein & Cell》更多>>
相关主题：英文MOUSEINSULINDB/DBPANCREATIC更多>>
相关领域：生物学医药卫生电气工程更多>>
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调控KIF1A二聚化和活性的潜在的磷酸化位点(英文)
《生物化学与生物物理进展》2014年第9期870-876,821,共7页刘贝 岳旸 俞勇 任锦启 冯巍 霍麟 徐涛 
supported by grants from The National Basic Research Program of China(2010CB833701,2011CB910503,2014CB910202);The National Natural Science Foundation of China(31130065,31300611,31190062,31200577)~~
驱动蛋白kinesin-3家族中的KIF1A蛋白主要参与轴突上分泌囊泡前体的正向运输.KIF1A中的CC1-FHA片段能够形成稳定的二聚体结构,同时促进驱动蛋白的活性,但是其具体的调节机制尚未清楚.基于已有的CC1-FHA二聚体的晶体结构,我们发现在二聚...
关键词：KIF1A 磷酸化 二聚化 轴突运输 
Ultra-structural study of insulin granules in pancreaticβ-cells of db/db mouse by scanning transmission electron microscopy tomography被引量：3
《Protein & Cell》2012年第7期521-525,共5页Yanhong Xue Wei Zhao Wen Du Xiang Zhang Gang Ji Wang Ying Tao Xu 
supported by grants from the National Basic Research Program of China(No.2010CB833701);the National Natural Science Foundation of China(Grant Nos.31130065 and 31100596).
Insulin granule trafficking is a key step in the secretion of glucose-stimulated insulin from pancreaticβ-cells.The main feature of type 2 diabetes(T2D)is the failure of pancreaticβ-cells to secrete sufficient amoun...
关键词：INSULIN secretory granule diabetes stem TOMOGRAPHY 3D reconstruction 
UNC-10在致密核心囊泡分泌过程中的作用(英文)
《生物化学与生物物理进展》2012年第6期556-562,共7页冯婉娟 周围 章永登 吴政星 徐涛 
supported by grants from National Basic Research Program of China(2010CB833701);The National Natural Science Foundation of China(30870564,90913022);Key Inndvative Project of Chinese Academy of Sciences(KSCX2-SW-224)~~
Rim是囊泡分泌活性区中的重要组成蛋白,它与细胞分泌和突触可塑性相关.在秀丽隐感线虫中只存在一种编码Rim的基因即unc-10.我们的研究发现,在线虫中Rim的基因突变unc-10(md1117)会导致致密核心囊泡的分泌缺陷.在活体中,unc-10突变虫系...
关键词：秀丽隐杆线虫 致密核心囊泡 UNC-10 细胞分泌 
RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C.elegans被引量：1
《Science China(Life Sciences)》2012年第3期228-235,共8页FENG Wan Juan LIANG Tao YU JunWei ZHOU Wei ZHANG YongDeng WU ZhengXing XU Tao 
supported by the National Basic Research Program of China(Grant No. 2010CB833701);the National Natural Science Foundation of China(Grant Nos. 30870564 and 90913022);the CAS Project(Grant No.KSCX2-SW-224)
The molecular mechanisms by which dense core vesicles(DCVs) translocate,tether,dock and prime are poorly understood.In this study,Caenorhabditis elegans was used as a model organism to study the function of Rab protei...
关键词：EXOCYTOSIS dense core vesicles RAB-3 RAB-27 C. elegans total internal reflection fluorescence microscopy 
HID-1 is a peripheral membrane protein primarily associated with the medial-and transGolgi apparatus被引量：2
《Protein & Cell》2011年第1期74-85,共12页Lifen Wang Yi Zhan Eli Song Yong Yu Yaming Jiu Wen Du Jingze Lu Pingsheng Liu Pingyong Xu Tao Xu 
the National Science Foundation of China(Grant Nos.30870564,and 30900268),The Beijing Natural Science Foundation(No.5092017);the Major State Basic Research Program of China(No.2010CB833701);the CAS Project(KSCX2-SW-224 and Novo Nordisk-CAS to P Xu).
Caenorhabditis elegans hid-1 gene was first identified in a screen for mutants with a high-temperature-induced dauer formation(Hid)phenotype.Despite the fact that the hid-1 gene encodes a novel protein(HID-1)which is ...
关键词：HID-1 GOLGI peripheral membrane protein fluorescent recovery after photobleaching N-MYRISTOYLATION 
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