高等学校学科创新引智计划(B08011)

作品数：9被引量：5H指数：1
导出分析报告
相关作者：张涛段广有张磊高山张宁更多>>
相关机构：南开大学天津中医药大学天津医科大学更多>>
相关期刊：《Science China(Life Sciences)》《Virologica Sinica》《遗传》《南开大学学报（自然科学版）》更多>>
相关主题：OCT4SOX2MIGRATIONENDOTHELIAL_CELLPOLARIZATION更多>>
相关领域：医药卫生生物学农业科学更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-9
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Coassembly of Macrocyclic Amphiphiles for Anti-β-Amyloid Therapy of Alzheimer’s Disease被引量：1
《CCS Chemistry》2021年第9期2485-2497,共13页Yu-Chen Pan Hui Wang Xinxin Xu Han-Wen Tian Hong Zhao Xin-Yue Hu Yu Zhao Yang Liu Guihua Ding Qingbin Meng Bart Jan Ravoo Tao Zhang Dong-Sheng Guo 
from NSFC(grant nos.51873090,31961143004,31771148,and 31900733);111 Project(grant no.B08011);the Fundamental Research Funds for the Central Universities,and NCC Fund(grant no.NCC2020FH04).
Based on the amyloid hypothesis,anti-β-amyloid(Aβ)therapy has dominated clinical trials for the prevention and treatment of Alzheimer’s disease(AD)in recent years.A key element of this strategy is the interaction b...
关键词：macrocyclic amphiphile heteromultivalent recognition fibril disintegration cognitive improvement Alzheimer’s disease 
Lysine residues K66, K109, and K110 in the bovine foamy virus transactivator protein are required for transactivation and viral replication
《Virologica Sinica》2016年第2期142-149,共8页Suzhen Zhang Xiaoxu Cui Jing Li Zhibin Liang Wentao Qiao Juan Tan 
supported by grants from the National Natural Science Foundation of China(Na.31370182);Tianjin Research Program and Application Foundation and Advanced Technology(Na.12YFQNJC02300);111 Project(B08011)
Bovine foamy virus(BFV) is a complex retrovirus that infects cattle. Like all retroviruses, BFV encodes a transactivator Tas protein(BTas) that increases gene transcription from viral promoters.BFV encodes two promote...
关键词：residues replication mutant deletion length infectious cattle promoter lysine deficient 
HIV-1 Vpr protein activates the NF-κB pathway to promote G2/M cell cycle arrest被引量：1
《Virologica Sinica》2015年第6期441-448,共8页Zhibin Liang Ruikang Liu Yongquan Lin Chen Liang Juan Tan Wentao Qiao 
supported by grants from the Chinese Ministry of Health (2012ZX10001006);the National Natural Science Foundation of China (81271812 and 31370182);111 Project (B08011);the Postgraduate Scholarship Program of the China Scholarship Council
Viral protein R(Vpr) plays an important role in the replication and pathogenesis of Human immunodeficiency virus type 1(HIV-1). Some of the various functions attributed to Vpr, including the induction of G2/M cell cyc...
关键词：Human IMMUNODEFICIENCY virus type 1(HIV-1) VIRAL protein R(Vpr) NF-κB G2/M ARREST 
丹参酮IIA与雷洛昔芬联合用药对大鼠前列腺增生防治作用的实验研究
《南开大学学报（自然科学版）》2015年第2期54-58,共5页王超 杜小玲 赵肖玲 杨睿 樊官伟 高秀梅 石建党 张琚 
国家自然科学基金(81370859);国家重点基础研究发展计划(973计划)(2012CB723500);天津市科技计划(12ZCDZSY17000);111计划项目(B08011)
良性前列腺增生(BPH)是引起老年男性排尿障碍的常见疾病.本研究在雌雄激素诱导大鼠前列腺增生模型基础上,探究丹参酮IIA与雷洛昔芬联合用药对大鼠前列腺增生的防治作用.结果表明,与模型组相比,丹参酮IIA与雷洛昔芬联合用药显著抑制大鼠...
关键词：良性前列腺增生 丹参酮ⅡA 雷洛昔芬 雄激素受体 雌激素受体Α 
Expression and function of natural antisense transcripts in mouse embryonic stem cells
《Science China(Life Sciences)》2014年第12期1183-1190,共8页ZHAO Tong WU Zhao Ting WANG Si Yu CHEN Ling Yi 
supported by the National Natural Science Foundation of China(31271547);the Natural Science Foundation of Tianjin,China(14JYBJC23600);the National Key Basic Research and Development Program of China(2010CB833603);the Program for New Century Excellent Talents(NCET-13-0293);the 111 Project Grant(B08011);the Funds for National Basic Science Personnel Training(J1103503)
Non-coding RNAs(nc RNAs),such as micro RNAs and large intergenic non-coding RNAs,have been shown to play essential roles in regulating pluripotency.Yet,it is not clear the role of natural antisense transcripts(NATs),a...
关键词：natural antisense transcripts embryonic stem cells SOX2 OCT4 PLURIPOTENCY 
小鼠胚胎干细胞中天然反义转录物的表达及功能研究
《中国科学：生命科学》2014年第9期871-878,共8页赵彤 吴曌婷 王斯羽 陈凌懿 
国家自然科学基金(批准号:31271547);国家重点基础研究发展计划(批准号:2010CB833603);新世纪优秀人才支持计划(批准号:NCET-13-0293);高等学校学科创新引智计划(批准号:B08011);国家基础科学人才培养基金项目(批准号:J1103503)资助
非编码RNA(ncRNA),如小分子RNA和基因间长链非编码RNA在调控多能性方面发挥着重要的作用.然而,天然反义转录物(NAT)在胚胎干细胞中的作用并不清楚.本研究首先通过数字基因表达谱发现在小鼠胚胎干细胞中存在广泛的NAT表达,随后证实了Oct4...
关键词：天然反义转录物 胚胎干细胞 SOX2 OCT4 多能性 
Directed Evolution of Insoluble Arabidopsis thaliana Zeta Class Glutathione S-Transferase Mutants for Higher Solubility in Escherichia coli
《Journal of Genetics and Genomics》2013年第6期319-322,共4页Yicun Wang Feng Zhang Haiwei Chen Xiwen Chen Defu Chen 
supported by the grants of the National Natural Science Foundation of China(No.31070717);Tianjin International Science and Technology Cooperation Project (No.09ZCGHHZ00500);the 111 Project(No.B08011)
Expression of recombinant protein in Escherichia coli （E.coli） is generally considered as one of the ideal systems to produce proteins for industrial production.However,the majority of proteins usually fail to fold ...
关键词：Directed Evolution of Insoluble Arabidopsis thaliana Zeta Class Glutathione S-Transferase Mutants for Higher Solubility in Escherichia coli coli 
Regulation of tumor angiogenesis by the microtubule-binding protein CLIP-170被引量：2
《Protein & Cell》2013年第4期266-276,共11页Xiaodong Sun Fang Li Bin Dong Shaojun Suo Min Liu Dengwen Li Jun Zhou 
supported by grants from the National Basic Research Program(973 Program)(Nos.2012CB945002,2010CB912204);National Natural Science Foundation of China(Grant Nos.31130015 and 31271437);the 111 project from the Ministry of Education of China(B08011).
Angiogenesis,the expansion of preexisting blood vessels,is a complex process required for tumor growth and metastasis.Although current antiangiogenic strategies have shown promising results in several cancer types,ide...
关键词：tumor angiogenesis endothelial cell MIGRATION POLARIZATION MICROTUBULE 
人类变异组计划及其进展被引量：1
《遗传》2010年第11期1105-1113,共9页高山 张宁 张磊 段广有 张涛 
国家自然科学基金项目(编号:30870827;60875049);高等学校学科创新引智计划项目(编号:B08011);南开大学优秀博士培育基金资助
基因组学构建了人类的基因组图谱,后基因组时代的主要任务是解释基因组如何影响生命活动,由此产生了各种新类型的组学:结构基因组学,功能基因组学,蛋白质组学,代谢组学等。人类基因组突变学会于2006年6月在澳大利亚的墨尔本会议上正式...
关键词：变异组 突变 变异 多态性 表型 
全选清除导出
共1页<1>
检索报告 对象比较 聚类工具 使用帮助 返回顶部