This work was supported by the grants from the National Natural Science Foundation of China (30571844) and the Natural Science Foundation of Shandong Province (2009ZRB14005).
Heparanase is a mammalian endoglycosidase that degrades heparan sulfate at the cell surface and in the extracellular matrix. The expression of heparanase was detected in a wide variety of human malignant tumors and cl...