HEPARANASE

作品数：51被引量：308H指数：9
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相关作者：郭春和陈勇杜建军窦科峰王中华更多>>
相关机构：安徽医科大学中山大学河北医科大学第四军医大学西京医院更多>>
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Shenfushu granules attenuate diabetic kidney disease by inhibiting PIK3R1/protein kinase B/heparanase-mediated endothelialmesenchymal transition
《World Journal of Diabetes》2025年第5期297-316,共20页Xi-Ding Yang Si-Jia Ma Da-Xiong Xiang Yong-Yu Yang 
Supported by the Changsha Science and Technology Major Project,No.kh2205035;the Hunan Traditional Chinese Medicine Science and Technology Project,No.2021061;the Natural Science Foundation of Hunan Province,No.2025JJ80080。
BACKGROUND Injury to the glomerular filtration barrier causes diabetic kidney disease(DKD),and glomerular endothelial-mesenchymal transition damages the filtration barrier of glomerular endothelial cells.Shenfushu gra...
关键词：Diabetic kidney disease Glomerular filtration barrier GLYCOCALYX Shenfushu granules PIK3R1 Heparanase-1 Endothelial-mesenchymal transition 
TROVE2 regulated invasion and migration of hepatocellular carcinoma cells via heparanase
《Oncology and Translational Medicine》2024年第2期66-72,共7页Niangmei Cheng Xiaoyuan Zheng Jingyun Huang FeiWang Yang Wang Yue Zhong Yingchao Wang Gaoxiong Wang Bixing Zhao 
the Natural Science Foundation of Fujian Province(2021 J01539,2023 J011467);Scientific Foundation of the Fuzhou Health Commission(2021-S-wq21,2021-S-wp1).
Background:The role of TROVE domain family member 2(TROVE2)has been well-demonstrated in autoimmune diseases;however,its involvement in liver cancer remains unclear.Therefore,this study aimed to explore the biological...
关键词：Epithelial-mesenchymal transition(EMT) Heparanase(HPSE) Hepatocellular carcinoma(HCC) TROVE2 
Heparanase inhibition leads to improvement in patients with acute gastrointestinal injuries induced by sepsis
《World Journal of Gastroenterology》2023年第35期5154-5165,共12页Ting-Ting Chen Jia-Jun Lv Ling Chen Min Li Li-Ping Liu 
the Science and Technology Department of Gansu Province,No.20JR5RA35;Science and Technology Project of Gansu Province,No.22JR10KA009;Talent Innovation and Entrepreneurship Project of Science and Technology Bureau of Chengguan District,Lanzhou,No.2020RCCX0030;Lanzhou Science and Technology Development Guiding Plan Project,No.2019-ZD-37.
BACKGROUND Patients with sepsis are at high risk for acute gastrointestinal injury(AGI),but the diagnosis and treatment of AGI due to sepsis are unsatisfactory.Heparanase(HPA)plays an important role in septic AGI(S-AG...
关键词：SEPSIS Acute gastrointestinal injury HEPARANASE Autophagy 
Changes in Lipoprotein Lipase in the Heart Following Diabetes Onset
《Engineering》2023年第1期19-25,共7页Chae Syng Lee Yajie Zhai Brian Rodrigues 
supported by operating grants from the Canadian Institutes of Health Research(CIHR PJT-178134 and PJT-169212).
Due to its constant pumping and contraction, the heart requires a substantial amount of energy, with fatty acids (FAs) providing a major part of its adenosine triphosphate (ATP). However, the heart is incapable of mak...
关键词：Cardiac metabolism Lipopr otein lipase HEPARANASE Vascular endothelial growth factor Diabetic car diomyopathy 
Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression被引量：2
《World Journal of Gastroenterology》2021年第22期3138-3141,共4页Li-Ping Liu Xi-Ping Sheng Tian-Kui Shuai Yong-Xun Zhao Bin Li Yu-Min Li 
Correction to"Liu LP,Sheng XP,Shuai TK,Zhao YX,Li B,Li YM.Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression.World J Gastroenterol 2018;24:4565-4577[PMID:30386106...
关键词：Correction Replace the wrong pictures Gastric cancer Helicobacter pylori 
Helicobacter pylori promotes invasion and metastasis of gastric cancer by enhancing heparanase expression被引量：12
《World Journal of Gastroenterology》2018年第40期4565-4577,共13页Li-Ping Liu Xi-Ping Sheng Tian-Kui Shuai Yong-Xun Zhao Bin Li Yu-Min Li 
Supported by the Natural Science Foundation of Gansu Province,No.1506RJZA255;the National Natural Science Foundation of China,No.81572437;the Open Topics of the Key Laboratory of Biological Treatment and Regenerative Medicine in Gansu Province,No.zdsyskfkt-201702;the Fund of Donggang Branch,The First Hospital of Lanzhou University,No.ldyydgyn-201705
AIM To detect the mechanisms of Helicobacter pylori(H. pylori) infection in the invasion and metastasis of gastric cancer(GC).METHODS Specimens from 99 patients with GC were collected. The correlation among H. pylori ...
关键词：Gastric cancer HELICOBACTER PYLORI HEPARANASE MITOGEN-ACTIVATED protein kinase Overall SURVIVAL Relapse-free SURVIVAL 
CTC clusters induced by heparanase enhance breast cancer metastasis被引量：7
《Acta Pharmacologica Sinica》2018年第8期1326-1337,共12页Rong-rui WEI Dan-ni SUN Hong YANG Juan YAN Xiong ZHANG Xing-ling ZHENG Xu-hong FU Mei-yu GENG Xun HUANG Jian DING 
This work was supported by the National Natural Science Foundation of China （No 81302791）, the Youth Innovation Promotion Association CAS, the Strategic Priority Research Program of the Chinese Academy of Sciences （No XDA12020326） and the Shanghai Talent Development Funds （No 201663）, all awarded to Xun HUANG.
Aggregated metastatic cancer cells, referred to as circulating tumor cell （CTC） clusters, are present in the blood of cancer patients and contribute to cancer metastasis. However, the origin of CTC clusters, especia...
关键词：human breast cancer CTC clusters HEPARANASE METASTASIS cell adhesion adhesion molecules suspension culture method 
GubenyiliuⅡ inhibits breast tumor growth and metastasis associated with decreased heparanase expression and Akt phosphorylation
《中国药理学与毒理学杂志》2016年第10期1076-1076,共1页ZHANG Yi ZHANG Gan-lin SUN Xu CAO Ke-xin SHANG Ya-wen GONG Mu-xin MA Cong NAN Nan LI Jin-ping YU Ming-wei YANG Guo-wang WANG Xiao-min 
The project supported by National Natural Science Foundation of China(81202840,81373815);Specialized Research Fund for the Doctoral Program of Higher Education of China(20131107110014);Beijing Natural Science Foundation(7162084);Swedish Cancer Foundation(150815)
OBJECTIVE GubenyiliuⅡ(GYⅡ),a traditional Chinese medicine(TCM)formula used in our hospital,has shown beneficial effects in cancer patients.In this study,we investigated the molecular mechanisms underlying the benefi...
关键词：Gubenyiliu Ⅱ breast tumor HEPARANASE growth factors ERK AKT pathways 
肝素酶促进肿瘤侵袭及CAR-T细胞抗肿瘤活性
《生理科学进展》2015年第6期414-414,共1页杨祎 
嵌合抗原受体修饰T淋巴细胞（chimeric antigen receptor-redirected T lymphocytes,CAR-T cells）技术是近几年肿瘤免疫治疗突破性方法之一,在一系列临床试验中取得显著疗效,成为新的研究热点。然而目前CAR-T技术主要应用于血液性肿瘤...
关键词：肿瘤免疫治疗 肿瘤侵袭 CAR-T细胞 美国休斯顿 贝勒大学 肿瘤实质 HEPARANASE 抗原受体 实质性肿瘤 肝素酶 
Heparanase activates the syndecan-syntenin-ALIX exosome pathway被引量：30
《Cell Research》2015年第4期412-428,共17页Bart Roucourt Sofie Meeussen Jie Bao Pascale Zimmermann Guido David 
Exosomes are secreted vesicles of endosomal origin involved in signaling processes. We recently showed that the syndecan heparan sulfate proteoglycans control the biogenesis of exosomes through their interaction with ...
关键词：heparan sulfate SYNDECAN HEPARANASE SYNTENIN exosome biogenesis exosomal cargo 
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