云南高校图书馆联盟文献共享服务平台- SYNDECAN

SYNDECAN: 作品数：11被引量：55H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李诗豪冯智毅孙佳音周玉杰杨辉更多>>; 相关机构：中国科学院广州医科大学首都医科大学附属北京安贞医院第四军医大学口腔医院更多>>; 相关期刊：《临床医学进展》《中国现代医学杂志》《World Journal of Gastroenterology》《Chinese Medical Journal》更多>>; 相关基金：国家自然科学基金更多>>

Syndecan在疾病过程中的研究进展: 《临床医学进展》2023年第6期9634-9640,共7页陈东平苏娟; Syndecan是一种具有四个成员的跨膜硫酸乙酰肝素蛋白聚糖(HSPGs)。这些蛋白多糖由一个核心蛋白和以共价键方式连接在核心蛋白上的一条或者多条硫酸乙酰肝素糖(GAG)链组成,它们能够参与多种生命活动的调控,在生长、发育、微生物和病毒感...; 关键词：硫酸乙酰肝素蛋白聚糖多配体蛋白聚糖炎症相关性疾病肿瘤

Syndecan 4-c-ros oncogene 1 fusion as a mechanism of acquired resistance in epidermal growth factor receptor mutant lung adenocarcinoma被引量：1: 《Chinese Medical Journal》2019年第24期3015-3017,共3页You-Cai Zhu Chun-Wei Xu Qu-Xia Zhang Wen-Xian Wang Lei Lei Wu Zhuang; This study was supported by a grant from the Science and Technology Planning Project of Zhejiang Province(No.LGF19H160002).; To the Editor:A 37-year-old Chinese woman,a nonsmoker,presented with adenocarcinoma of the left lung(stage IV)[Figure 1A],malignant pleural effusion,and multiple bone metastases in December 2014.Deoxyribonucleic acid ...; 关键词：ADENOCARCINOMA FIGURE SMOKE

Pleiotrophin and N-syndecan promote perineural invasion and tumor progression in an orthotopic mouse model of pancreatic cancer被引量：5: 《World Journal of Gastroenterology》2017年第21期3907-3914,共8页Jun Yao Lu-Lin Zhang Xu-Mei Huang Wen-Yao Li She-Gan Gao; Supported by the National Natural Science Foundation of China,No.U1204819;Health Science and Technology Innovation Talents Program of Henan Province,No.4203; AIM To detect the expression of pleiotrophin(PTN) and N-syndecan in pancreatic cancer and analyze their association with tumor progression and perineural invasion(PNI).METHODS An orthotopic mouse model of pancreatic c...; 关键词：PLEIOTROPHIN N-syndecan Pancreatic cancer Perineural invasion

Syndecan 4促进心肌细胞生理性肥大研究被引量：1: 《心肺血管病杂志》2016年第12期986-991,共6页孙佳音周玉杰; 北京市医院管理局"登峰"计划专项经费资助(DFL20150601); 目的:研究syndecan 4(Synd4)在心肌细胞生理性肥大中的作用及其机制。方法:将大鼠心肌细胞分为对照腺病毒组(Ad-lacz组),Synd4腺病毒转染组(Ad-synd4组),腺病毒+胰岛素样生长因子组(Ad-lacz+IGF组)和腺病毒+异丙肾上腺素组(Ad-lacz+ISO...; 关键词：SYNDECAN 4 心肌细胞生理性肥大

Surface-modified liposomes for syndecan 2-targeted delivery of edelfosine被引量：2: 《Asian Journal of Pharmaceutical Sciences》2016年第5期596-602,共7页Gayong Shim Yong Hee Yu Soondong Lee Jinyoung Kim Yu-Kyoung Oh; Here, we report that the modification of liposome surfaces with AG73 peptides enhances delivery of the lipophilic anticancer drug, edelfosine, to tumor cells overexpressing the cellsurface receptor, syndecan 2. To tes...; 关键词：LIGAND density AG73 PEPTIDE SYNDECAN 2 LIPOSOME ANTICANCER drug EDELFOSINE

黏结蛋白聚糖2及E-钙黏蛋白的表达及与结直肠腺癌淋巴结转移的关系被引量：2: 《中国现代医学杂志》2016年第2期72-75,共4页冯智毅; 目的探讨黏结蛋白聚糖2（syndecan 2）和E-钙黏蛋白（E-cadherin）表达与结直肠腺癌侵袭、转移的关系。方法应用免疫组织化学SP法检测75例结直肠腺癌中的syndecan 2和E-Cadherin的表达,45例腺瘤性息肉、30例正常结直肠做对照组,采用SP...; 关键词：结直肠腺癌 SYNDECAN 2 E-CADHERIN 淋巴结转移

Heparanase activates the syndecan-syntenin-ALIX exosome pathway被引量：30: 《Cell Research》2015年第4期412-428,共17页Bart Roucourt Sofie Meeussen Jie Bao Pascale Zimmermann Guido David; Exosomes are secreted vesicles of endosomal origin involved in signaling processes. We recently showed that the syndecan heparan sulfate proteoglycans control the biogenesis of exosomes through their interaction with ...; 关键词：heparan sulfate SYNDECAN HEPARANASE SYNTENIN exosome biogenesis exosomal cargo

Pleiotrophin promotes perineural invasion in pancreatic cancer被引量：12: 《World Journal of Gastroenterology》2013年第39期6555-6558,共4页Jun Yao Xiu-Feng Hu Xiao-Shan Feng She-Gan Gao; Supported by National Natural Science Foundation of China,No.U1204819;Health Science and Technology Innovation Talents Program of Henan Province,China,No.4203; Perineural invasion(PNI)in pancreatic cancer is an important cause of local recurrence,but little is known about its mechanism.Pleiotrophin(PTN)is an important neurotrophic factor.It is of interest that our recent exp...; 关键词：PLEIOTROPHIN N-syndecan NEURITE OUTGROWTH Perineural invasion PANCREATIC cancer

Fibrogenesis and fibrosis in inflammatory bowel diseases:Good and bad side of same coin?被引量：2: 《World Journal of Gastrointestinal Pathophysiology》2013年第4期100-107,共8页Mariabeatrice Principi Floriana Giorgio Giuseppe Losurdo Viviana Neve Antonella Contaldo Alfredo Di Leo Enzo Ierardi; Fibrogenesis in inflammatory bowel diseases is a complex phenomenon aimed at mucosal repair. However, it may provoke intestinal fibrosis with the development of strictures which require surgery. Therefore, fibrogenes...; 关键词：FIBROGENESIS FIBROSIS Tumor necrosis factor-α SYNDECAN 1 Basic FIBROBLAST growth FACTOR Cellular fibrogenic phenotype Inflammatory bowel diseases

Altered molecular pattern of mucosal healing in Crohn's disease fibrotic stenosis被引量：2: 《World Journal of Gastrointestinal Pathophysiology》2013年第3期53-58,共6页Enzo Ierardi Floriana Giorgio Domenico Piscitelli Mariabeatrice Principi Santina Cantatore Maria Grazia Fiore Roberta Rossi Michele Barone Alfredo Di Leo Carmine Panella; AIM: To investigate tumor necrosis factor-α (TNF-α), syndecan 1 and basic fibroblast growth factor (bFGF) balance in Crohn's disease (CD) strictures. METHODS: Our study was performed on 24 surgical specimens of CD f...; 关键词：Crohn’s disease Fibrotic STENOSIS Tumor NECROSIS factor-α SYNDECAN 1 Basic FIBROBLAST growth FACTOR

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