国家自然科学基金(JQ201019)

作品数：7被引量：6H指数：2
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Visualization of α_1-adrenergic receptors with phenylpiperazine-based fluorescent probes
《Science China Chemistry》2016年第5期624-628,共5页Yuxing Lin Wenhua Li Qinying Yu Xinyang Zhou Wei Zhang Lupei Du Minyong Li 
supported by the Fok Ying Tong Education Foundation (122036);the Program of New Century Excellent Talents in University (NCET-11-0306);the Major Project of Science and Technology of Shandong Province (2015ZDJS04001);the Shandong Natural Science Foundation (JQ201019);the Independent Innovation Foundation of Shandong University (2010JQ005)
Several novel fluorescent probes targeting α_1-adrenergic receptors were well designed and synthesized by conjugating phenylpiperazine pharmacophore with coumarin and fluorescein fluorophores. These compounds showed ...
关键词：α1-adrenergic receptors fluorescent probes high affinity fluorescent imaging 
Discovery of naphthalimide conjugates as fluorescent probes for α_1-adrenoceptors被引量：1
《Chinese Chemical Letters》2016年第2期185-189,共5页Wei Zhang Xin-Yang Zhou Qin-Ying Yu Lu-Pei Du Min-Yong Li 
supported by grants from the Fok Ying Tong Education Foundation (No. 122036);the Program of New Century Excellent Talents in University (No. NCET-11-0306);the Shandong Natural Science Foundation (No. JQ201019);the Independent Innovation Foundation of Shandong University, IIFSDU (No. 2010JQ005)
α1-Adrenoceptors（α1-ARs）, including at least three subtypes, α（1A）, α（1B） and α（1D）, which play essential roles in G protein-coupled receptors（GPCRs）, can convey multiple pivotal extracellular signals i...
关键词：α1-Adrenergic receptors Fluorescent probes High affinity Cell imaging 
BioLeT: A new design strategy for functional bioluminogenic probes被引量：1
《Chinese Chemical Letters》2015年第8期919-921,共3页Tian-Chao Zhang Lu-Pei Du Min-Yong Li 
Financial support from the National Program on Key Basic Research Project(No.2013CB734000);the Program of New Century Excellent Talents in University(No.NCET-11-0306);the Shandong Natural Science Foundation(No.JQ201019);the Fundamental Research Funds of Shandong University(No.2014JC008)
By integrating photoinduced electron transfer（PET） into the design of functional bioluminogenic probes,Urano and his coworkers recently developed a new rational design strategy, BioLeT. It is expected that this BioL...
关键词：probes detecting enable integrating rational utilized challenging instead absolute moiety 
A bestatin-based fluorescent probe for aminopeptidase N cell imaging被引量：2
《Chinese Chemical Letters》2015年第5期513-516,共4页Hui Chen Hui Wang Xiao-Jun Qin Chen Chen Lu Feng Lai-Zhong Chen Lu-Pei Du Min-Yong Li 
supported by the Program for New Century Excellent Talents in University(No.NCET-11-0306);the Shandong Natural Science Foundation(No.JQ201019);the Independent Innovation Foundation of Shandong University, IIFSDU(No.2014JC008);the Graduate Independent Innovation Foundation of Shandong University,GIIFSDU(No.yzcl2096)
Aminopeptidase N （APN） is an important drug target and biomarker for various tumors. The current work characterizes a novel APN-targeted fluorescent probe （Bes-Green, 2） that manifests comparable inhibitory activi...
关键词：Aminopeptidase N Bestatin Cell imaging Fluorescent probe 
Fluorescence triggered by ligand-protein hydrophobic interaction
《Science China Chemistry》2013年第11期1667-1670,共4页LIU ZhenZhen DU LuPei LI MinYong 
supported by the National Natural Science Foundation of China (81370085);the Program of New Century Excellent Talents in University (NCET-11-0306);the Fok Ying Tong Education Foundation (122036);the Shandong Natural Science Foundation (JQ201019);the Independent Innovation Foundation of Shandong University (2010JQ005 and 2012JC002).
Hydrophobic fluorescence:Tan and his colleagues recently introduced a brand new chemotype of environment-sensitive fluorescent turn-on probes to detect the hydrophobic ligand-binding domain by using SBD fluorophore.Th...
关键词：non-enzyme protein environment-sensitive probe turn-on fluorescence SBD fluorophore 
Bifunctional fluorescent probes for hydrogen peroxide and diols based on a 1,8-naphthalimide fluorophore
《Science China Chemistry》2013年第10期1440-1445,共6页SUN Wei MA Zhao LI Jing LI WenHua DU LuPei LI MinYong 
supported by the Shandong Natural Science Foundation(JQ201019);the Independent Innovation Foundation of Shandong University,IIFSDU(2010JQ005)
This report discloses a series of naphthalimide-based bifunctional fluorescent probes for hydrogen peroxide and diols.As a result,these molecules not only demonstrated high turn-on fluorescent response and good select...
关键词：1 8-NAPHTHALIMIDE bifunctional fluorescent probe hydrogen peroxide DIOLS 
Design of OFF/ON fluorescent thiol probes based on coumarin fluorophore被引量：2
《Science China Chemistry》2012年第9期1776-1780,共5页SUN Wei LI Jing LI WenHua SU LiJuan DU LuPei LI MinYong 
financed by grants from Shandong Natural Science Foundation (JQ201019);Independent Innovation Foundation of Shandong University,IIFSDU (2010JQ005)
This paper presents a series of first- and second-generation click-modified coumarin-based fluorescent probes for thiols. These molecules demonstrate high turn-on fluorescent response and good selectivity towards arom...
关键词：COUMARIN fluorescent probe aliphatic thiols THIOPHENOLS 
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