国家自然科学基金(30525010)

作品数：6被引量：58H指数：5
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从人类基因组到人造生命:克雷格·文特尔领路生命科学被引量：18
《生物工程学报》2010年第6期697-706,共10页孙明伟 李寅 高福 
国家自然科学基金委员会杰出青年科学基金(No.30525010)资助~~
2010年5月20日,美国Science杂志报道J.Craig Venter的研究小组制造了第一个能够自我复制的人工合成生命,并立即引发了人们对这一研究潜在威胁的担忧和有关生物安全和生物伦理的讨论。但同时,这一成果也是人类在合成生物学领域的一次突...
关键词：人造生命 克雷格·文特尔 人类基因组计划 合成生物学 
Crystal structure of the swine-origin A (H1N1)- 2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus被引量：11
《Protein & Cell》2010年第5期459-467,共9页Wei Zhang Jianxun Qi Yi Shi Qing Li Feng Gao Yeping Sun Xishan Lu Qiong Lu Christopher J.Vavricka Di Liu Jinghua Yan George F.Gao 
This work is supported by the intramural grant of the Chinese Academy of Sciences(Grant No.KSCX2-YW-R-158);the National Basic Research Program(973 Program)(Grant Nos.2010CB534004 and 2005CB523001);G.F.G.is a distinguished young investigator of the NSFC(Grant No.30525010);Dr.Christopher Vavricka is,partly,supported by the Fellowship for Young International Scientists of the Chinese Academy of Sciences(Grant No.2009Y2BS2).
Influenza virus is the causative agent of the seasonal and occasional pandemic flu.The current H1N1 influenza pandemic,announced by the WHO in June 2009,is highly contagious and responsible for global economic losses ...
关键词：Influenza virus PANDEMIC 2009 1918 S-OIV hemagglutinin(HA) structure 
A dimeric structure of PD-L1: functional units or evolutionary relics?被引量：10
《Protein & Cell》2010年第2期153-160,共8页Yong Chen Peipei Liu Feng Gao Hao Cheng Jianxun Qi George F.Gao 
This work was supported by a grant from Ministry of Science and Technology(MOST)of China for the basic research program 973,Grant No.2006CB504204;a grant from National Natural Science Foundation(NSFC)of China,Grant No.30671903;a grant from Chinese Academy of Sciences(CAS)Knowledge Innovation Project,Grant No.KSCX2-SW-227;G.F.G.is a distinguished young investigator of the NSFC(Grant No.30525010);Y.C.is a Ph.D.student supported by Science Innovation Project,Graduate University of Chinese Academy of Sciences(GUCAS),No.0729031EE1;The China-Japan Joint Laboratory of Molecular Immunology and Molecular Microbiology is partlially supported by Japan MEXT(Ministry of Education,Culture,Sports,Science and Technology).
PD-L1 is a member of the B7 protein family,most of whose members so far were identified as dimers in a solution and crystalline state,either complexed or uncomplexed with their ligand(s).The binding of PD-L1 with its ...
关键词：PD-L1 crystal structure DIMER costimulatory molecules B7 family 
It is not just AIV:From avian to swine-origin influenza virus被引量：10
《Science China(Life Sciences)》2010年第1期151-153,共3页GAO George F 
supported by the Intramural grant of the Chinese Academy of Sciences (CAS, Grant No KSCX2-YW-R-158);the National Natural Science Foundation of China (NSFC, Grant No 30599434);the Ministry of Science and Technology (MOST) 973 Proect (Grant No 2005CB523001);GFG is a distinguished young investigator of the NSFC (Grant No 30525010)
In March and early April 2009,a new swine-origin influenza A (H1N1) virus (S-OIV) emerged in Mexico and the United States. The virus spreads worldwide by human-to-human transmission.
关键词：gene In It is not just AIV 
Stable non-synonymous substitutions on NS gene (NS1 and NS2 proteins) of Qinghai lake H5N1 influenza virus (Clade 2.2) after successive passages in Muscovy ducks被引量：1
《Science China(Life Sciences)》2009年第9期847-853,共7页GAO George F. 
Supported by the National Natural Science Foundation of China (Grant No. 30599434);the National Basic Research Program of China (Grant No. 2005CB523001);a grant from NIH (Grant No. 3U19AI051915-05S1);GFG is a distinguished young investigator of the NSFC (Grant No. 30525010)
Although worldwide concern has been raised since the large-scale outbreak of highly pathogenic avian influenza in wild birds at Qinghai Lake,China in 2005,the factors responsible for the ability to kill waterfowl rema...
关键词：AVIAN INFLUENZA virus H5N1 mutation NS1/2 SERIAL passages 
Interspecies transmission and host restriction of avian H5N1 influenza virus被引量：14
《Science China(Life Sciences)》2009年第5期428-438,共11页GAO George Fu 
Supported by the National Basic Research Program of China (Grant Nos. 2005CB523001, 2005CB523002);National Key Technologies Research & Devel-opment Program (Grant 2006BAD06A01/ 2006BAD06A04);US National Institutes of Health (NIH) (Grant 3 U19 AI051915-05S1);the National Natural Science Foun-dation of China (Grant 30599434);GAO FG is a distinguished young investigator of the NSFC (Grant No. 30525010).
Long-term endemicity of avian H5N1 influenza virus in poultry and continuous sporadic human infections in several countries has raised the concern of another potential pandemic influenza. Suspicion of the avian origin...
关键词：H5N1 INFLUENZA VIRUS INTERSPECIES transmission VIRUS adaptation HOST factors 
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