云南高校图书馆联盟文献共享服务平台- 国家自然科学基金(20132020)

国家自然科学基金(20132020): 作品数：40被引量：93H指数：5; 导出分析报告; 相关作者：赵玉芬麻远蒋宇扬张建臣曹书霞更多>>; 相关机构：清华大学郑州大学教育部厦门大学更多>>; 相关期刊：《高等学校化学学报》《Science China Chemistry》《清华大学学报（自然科学版）》《化学进展》更多>>; 相关主题：N-SYNTHESIS氧OYL-2更多>>; 相关领域：理学生物学医药卫生化学工程更多>>

丝组二肽--现代蛋白酶分子进化过程中的原始雏形: 《中国科学：化学》2011年第4期579-586,共8页刘艳林铭堃陈培燕留筱厦杜海莲麻远赵玉芬; 国家自然科学基金(20132020,20732004,20805037);教育部基金(200803841009);福建省重点科技项目(2001F008)资助; 系统阐述了我们实验室近十五年来对丝组二肽的生物活性的研究.丝组二肽是目前报道的具有多种切割活性的最小活性肽,它不仅能够切割DNA,而且可以切割蛋白质及羧酸酯.丝组二肽是迷你的磷酸酯酶和蛋白水解酶,是现代蛋白酶分子进化过程中的...; 关键词：丝组二肽核酸切割蛋白切割蛋白酶的分子进化

N-氯苯基-2-脱氧-α-D-吡喃核糖亚胺的合成及其晶体结构: 《化学学报》2009年第9期989-995,共7页尚培华成昌梅杨萍王如骥赵玉芬; 国家自然科学基金(No.20132020)资助项目; 在水与甲醇的混合体系中,2-脱氧-D-核糖与氯代苯胺反应立体选择性地合成了三种N-氯苯基-2-脱氧-α-D-吡喃核糖亚胺(化合物1,2,3),它们的结构经过1HNMR和13CNMR的表征.将单一构型的N-对氯苯基-2-脱氧-α-D-吡喃核糖亚胺(1)溶于氘代DMSO...; 关键词：N-氯苯基-2-脱氧-α-D-吡喃核糖亚胺立体选择性合成构型异构化

Stereoselective Synthesis and Crystal Structure Analysis of N-Naphthyl-2-deoxy-α-D-ribopyranosylamine: 《Chinese Journal of Structural Chemistry》2009年第6期761-765,共5页尚培华成昌梅杨永冲王如骥赵玉芬; supported by the National Natural Science Foundation of China (No. 20132020); A new compound N-naphthyl-2-deoxy-α-D-ribopyranosylamine was synthesized and structurally determined. It crystallizes in the orthorhombic system, space group P212121 with a = 8.361（2）, b = 12.432（3）, c = 12.791（...; 关键词：N-naphthyl-2-deoxy-α-D-ribopyranosylamine synthesis X-ray diffraction crystal structure

Synthesis and Crystal Structure Analysis of 5′-O-Tosyl-2,3′-anhydrothymidine: 《Chinese Journal of Structural Chemistry》2008年第10期1175-1180,共6页赵兴俄尚培华成昌梅王如骥赵玉芬; the National Natural Science Foundation of China(No.20132020); In this paper, 5＇-O-tosyl-2,3＇-anhydrothymidine has been synthesized and its crystal structure was analyzed. The crystal belongs to the triclinic system, space group P1, with a = 5.397（2）, b = 6.1886（18）, c = 3....; 关键词：5＇-O-tosyl-2 3＇-anhydrothymidine SYNTHESIS X-ray diffraction crystal structure

Structure Study on N-Phenyl-2-deoxy-D-ribopyranosylamine: 《Chinese Journal of Structural Chemistry》2007年第12期1476-1480,共5页宋志伟李明海成昌梅陈朗秋郭晓强王如骥吴国是赵玉芬; Project supported by the National Natural Science Foundation of China (No. 20132020); The title compound N-phenyl-2-deoxy-D-ribopyranosylamine featuring a single conformation and pyranose-ring has been synthesized and characterized by NMR spectrum and X-ray diffraction. X-ray crystal structure analysis...; 关键词：N-phenyl-2-deoxy-D-ribopyranosylamine quantum chemical calculation Chair-conformation X-ray crystal structure

O-磷酸-L-丝氨酸及其衍生物的合成: 《有机化学》2007年第2期218-221,共4页张建臣曹书霞赵军峰廖新成赵玉芬; 国家自然科学基金(No.20132020)资助项目.; 介绍具有重要药理和生物活性的O-磷酸-L-丝氨酸及衍生物的合成.O-磷酸-L-丝氨酸通过部分水解的三氯氧磷与L-丝氨酸反应制得,并培养得到了其晶体,利用X射线衍射方法测定了它的晶体结构;进而合成了O-磷酸-L-丝氨酸钙盐和O-磷酸-L-丝氨酸单...; 关键词：L-丝氨酸 O-磷酸-L-N氨酸合成衍生物

结合丝组二肽的树状多肽对λDNA的切割: 《高等学校化学学报》2006年第10期1891-1893,共3页何骏麻远赵玉芬; 教育部留学回国人员科研启动基金;国家自然科学基金(批准号:20132020)资助.; Artificial nucleic acid cleavage agents have received considerable attention due to their very important applications in biochemistry and molecular biology.Seryl-histidine is a dipeptide possessing DNA,protein and est...; 关键词：丝组二肽树状多肽 DNA切割

DNA Binding and Cleavage Property of Pyrenyl-macrocyclic Polyamine Conjugate: 《Chinese Chemical Letters》2006年第9期1185-1188,共4页Qiang YIN Zhen ZHANG Yu Fen ZHAO; support from the National Natural Science Foundation of China(No.20132020);the National Science and Technology Committee of China,Chinese National Ministry of Education and Tsinghua University; We reported the synthesis of a simple bifunctional molecule and the interaction between this molecule and DNA were studied by UV and the DNA cleavage behavoior was determined by agarose gel electrophoresis.; 关键词：DNA cleavage ESI-MS UV agarose gel electrophoresis

Synthesis and Cleavage Activity of Artifical Minic Polypeptides被引量：2: 《Chinese Chemical Letters》2006年第9期1197-1200,共4页Yong YE Xiao Lian HU Ping LI Ming Yu NIU Li Feng CAO Yu Fen ZHAO; Two artificial minic polypeptides which are synthetic analogues of natural products with DNA affinity were synthesized, and theirs cleavage activity with DNA were examined. The structures of these compounds was confir...; 关键词：DNA artificial minic polypeptide cleavage agents.

具有DNA切割功能的新型多聚酰胺/丝组缀合物被引量：3: 《高等学校化学学报》2006年第7期1253-1256,共4页牛明玉叶勇刘伟张祯赵玉芬; 国家自然科学基金(批准号:20132020;20572061)资助; 为得到具有核酸切割功能的人工核酸酶,设计合成了一种新型多聚酰胺/丝组缀合物,并研究了其DNA切割活性.合成的目标化合物在pH=6.0的BR缓冲溶液中对pBR322 DNA切割活性的初步实验结果表明,于37℃保温6 h后,pBR322 DNA基本上被完全从Form...; 关键词：多聚酰胺/丝组缀合物 DNA 切割试剂

国家自然科学基金(20132020)