国家自然科学基金(81021003)

作品数：15被引量：133H指数：6
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Prophylactic cancer vaccine, from concept to reality?
《Chinese Science Bulletin》2014年第10期944-949,共6页Bao Zhao Xin Li Beinan Wang Bin Gao Songdong Meng 
supported by the National Natural Science Foundation of China(31230026,91029724,81021003 and 81102018);Beijing Natural Science Foundation(5112021)
The demonstration that for infectious diseases vaccine-induced immunity is in principle only effective before rather than after infection occurs,provides valuable insights in understanding the nature of immune system ...
关键词：PROPHYLACTIC cancer VACCINE GP96 PLACENTA Carcinoembryonic ANTIGENS Multivalentvaccine 
反义RNA寡核苷酸及其与脂质体的复合物对于乙型肝炎病毒的抑制（英文）
《生物化学与生物物理进展》2014年第4期362-370,共9页昝琰璐 田波 
supported by grants from The National Basic ResearchProgram of China(2011CB504703,2010CB530102);The NationalNatural Science Foundation of China(81021003)~~
我们设计合成了特异性靶向乙型肝炎病毒(HBV)mRNA的反义RNA寡核苷酸P-2987、X-60和X-519.在瞬时转染pHBV1.3质粒(含有1.3拷贝的HBV基因组)的HepG2细胞和整合了HBV基因组的HepG2.2.15细胞中,转染2μmol/L的反义RNA寡核苷酸,ELISA和实时定...
关键词：乙型肝炎病毒 反义RNA寡核苷酸 HBV转基因鼠 高压尾静脉注射 反义RNA寡核苷酸与脂质体复合物 
电转联合热休克蛋白佐剂疫苗引发抗HBV的免疫应答（英文）被引量：2
《生物工程学报》2013年第12期1765-1775,共11页徐亚星 王彦中 赵报 张小俊 范红霞 李星辉 孟颂东 
National Natural Science Foundation of China(Nos.31230026,30970146,91029724,81021003,81102018);Key Projects in the National Science&Technology Program(No.2013ZX10002001-003-003)~~
针对HBV感染的治疗性DNA疫苗虽然具有很好的应用前景,但目前抗病毒效果并不高,表明在病毒长期感染过程中存在免疫抑制机制。以HBV的表面蛋白(HBsAg)和核心蛋白(HBcAg)为DNA疫苗抗原,采用gp96和HSP70作为佐剂联合电转以提高疫苗的活性。...
关键词：GP96 HSP70 乙肝DNA疫苗 免疫治疗 
Origin and molecular characterization of the human-infecting H6N1 infl uenza virus in Taiwan被引量：27
《Protein & Cell》2013年第11期846-853,共8页Weifeng Shi Yi Shi Ying Wu Di Liu George F.Gao 
the National Basic Research Pro-gram(973 Program)(Nos.2010CB530303,2011CB504703,and 2012CB955501;an intramural special grant for influenza virus research from the Chinese Academy of Sciences(KSZD-EW-Z-002);the Doctoral Starting up Foundation of Taishan Medical College.GFG is a leading principal investigator of the Innova-tive Research Group of the National Natural Science Foundation of China(Grant No.81021003)。
In June 2013,the fi rst human H6N1 infl uenza virus infec-tion was confirmed in Taiwan.However,the origin and molecular characterization of this virus,A/Taiwan/2/2013(H6N1),have not been well studied thus far.In the p...
关键词：molecular characterization phylogenetic analysis coalescent analysis H6N1 infl uenza virus TAIWAN 
Crystal structures of the two membrane-proximal Ig-like domains(D3D4)of LILRB1/B2:alternative models for their involvement in peptide-HLA binding
《Protein & Cell》2013年第10期761-770,共10页Gol Nam Yi Shi Myongchol Ryu Qihui Wang Hao Song Jun Liu Jinghua Yan Jianxun Qi George F Gao 
the China National Grand S&T Spe-cial Project(No.2012ZX10001006);the National Natural Science Foundation of China(Grant No.31030030);GFG is a leading principal investigator of the NSFC Innovative Research Group(Grant No.81021003).
Leukocyte immunoglobulin-like receptors(LILRs),also called CD85s,ILTs,or LIRs,are important mediators of immune activation and tolerance that contain tandem immunoglobulin(Ig)-like folds.There are 11(in addition to tw...
关键词：LILRs D3D4 HLA binding crystal structure 
Duck egg drop syndrome virus:an emerging Tembusu-related flavivirus in China被引量：31
《Science China(Life Sciences)》2013年第8期701-710,共10页LIU PeiPei LU Hao LI Shuang WU Ying George Fu GAO SU JingLiang 
supported by the National Basic Research Program of China,Ministry of Science and Technology of China (2011CB504703);National Natural Science Foundation of China (81021003);Gao George Fu is a leading principal investigator of the NSFC Innovative Research Group
Duck egg drop syndrome virus(DEDSV) is a newly emerging pathogenic flavivirus isolated from ducks in China.DEDSV infection mainly results in severe egg drop syndrome in domestic poultry,which leads to huge economic lo...
关键词：DEDSV BYDV PATHOLOGY genome PHYLOGENY ANTIGENICITY vaccine 
Structure and receptor-binding properties of an airborne transmissible avian infl uenza A virus hemagglutinin H5(VN1203mut)被引量：11
《Protein & Cell》2013年第7期502-511,共10页Xishan Lu Yi Shi Wei Zhang Yanfang Zhang Jianxun Qi George F Gao 
the National Basic Research Program(973 Program)(No.2011CB504703);the National Natural Sci-ence Foundation of China(Grant No.81290342);.G.F.G.is a leading principal investigator of the NSFC Innovative Research Group(Grant No.81021003)。
Avian infl uenza A virus continues to pose a global threat with occasional H5N1 human infections,which is em-phasized by a recent severe human infection caused by avian-origin H7N9 in China.Luckily these viruses do no...
关键词：AIRBORNE transmission H5 avian infl uenza STRUCTURE receptor binding 
麻疹病毒受体与病毒侵入被引量：13
《生物工程学报》2013年第1期1-9,共9页逯光文 高福 严景华 
国家重点基础研究发展计划(973计划)(No.2011CB504703);国家自然科学基金创新研究群体研究基金(No.81021003)资助~~
麻疹病毒是一种具囊膜的负链RNA病毒,两种主要的囊膜蛋白血凝素蛋白(H)和膜融合蛋白(F)表达在膜表面负责病毒侵入过程中与宿主受体的结合和膜融合过程。病毒囊膜蛋白与受体的相互作用是病毒侵入宿主的关键步骤,决定了病毒感染能力、种...
关键词：麻疹病毒 受体 囊膜蛋白 病毒侵入 
An octamer of enolase from Streptococcus suis被引量：4
《Protein & Cell》2012年第10期769-780,共12页Qiong Lu Hao Lu Jianxun Qi Guangwen Lu George F Gao 
supported by National Natural Science Foundation of China(NSFC);a leading principal investigator of the NSFC Innovative Research Group(Grant No.81021003).
Enolase is a conserved cytoplasmic metalloenzyme existing universally in both eukaryotic and prokaryotic cells.The enzyme can also locate on the cell surface and bind to plasminogen,via which contributing to the mucos...
关键词：ENOLASE OCTAMER Streptococcus suis STRUCTURE plasminogen binding 
MiR-122 in hepatic function and liver diseases被引量：23
《Protein & Cell》2012年第5期364-371,共8页Jun Hu Yaxing Xu Junli Hao Saifeng Wang Changfei Li Songdong Meng 
supported by grants from the National Natural Science Foundation of China(Grant Nos.30970146,91029724,and 81021003).
As the most abundant liver-specific microRNA,mi-croRNA-122(miR-122)is involved in various physio-logical processes in hepatic function as well as in liver pathology.There is now compelling evidence that miR-122,as a r...
关键词：MIR-122 liver development lipid metabo-lism hepatitis C virus(HCV) hepatitis B virus(HBV) hepa-tocellular carcinoma(HCC) 
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