国家自然科学基金(81270544)

作品数:5被引量:15H指数:3
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相关作者:高润平齐丽娜田珍珍修明杨坤更多>>
相关机构:吉林大学第一医院江苏大学附属医院更多>>
相关期刊:《吉林大学学报(医学版)》《Hepatobiliary & Pancreatic Diseases International》《临床肝胆病杂志》更多>>
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氨溴索治疗戈谢病相关肝硬化门静脉高压症1例报告
《临床肝胆病杂志》2021年第4期908-909,共2页张玮 崔仕元 王珊珊 郑美芳 张鹏 高润平 
国家自然科学基金面上项目(81270544)。
戈谢病(Gaucher disease,GD)是一种罕见的常染色体隐性遗传病,该病是因葡糖脑苷脂酶(glycocerebrosidase,GBA)活性缺乏引起底物葡糖脑苷脂聚集于巨噬细胞溶酶体中而发病[1]。GD是一种慢性进展性和多器官系统可受累的疾病,多数Ⅰ型戈谢病...
关键词:戈谢病 肝硬化 氨溴索 
CD4+Foxp3+CD25+/-Tregs characterize liver tissue specimens of patients suffering from drug-induced autoimmune hepatitis:A clinical-pathological study被引量:3
《Hepatobiliary & Pancreatic Diseases International》2018年第2期133-139,共7页Li-Mei Qu Shu-Hua Wang Kun Yang David R.Brigstock Li Su Run-Ping Gao 
supported by a grant from the National Natural Science Foundation of China(81270544)
Background: The diagnosis of drug-induced autoimmune hepatitis(DIAIH) and its differentiation from idiopathic autoimmune hepatitis(AIH) is challenging. This study aimed to differentiate DIAIH from AIH by comparing the...
关键词:Drug-induced liver injury Autoimmune hepatitis Drug-induced autoimmune hepatitis Liver biopsy Regulatory T cells 
IgG4-related sclerosing cholangitis and chronic sclerosing sialadenitis mimicking cholangiocarcinoma and neck malignancy被引量:1
《Hepatobiliary & Pancreatic Diseases International》2017年第4期443-445,共3页Li Sun Hong-Yan Li David R Brigstock Run-Ping Gao 
supported by a grant from the National Natural Science Foundation of China(81270544)
To the Editor:IgG4-related sclerosing cholangitis(IgG4-SC)has re cently been recognized as a biliary manifestation of IgG4-related disease(IgG4-RD).Type 3 IgG4-SC pre sented biliary strictures in both the porta he...
关键词:IgG4-related sclerosing cholangitis and chronic sclerosing sialadenitis mimicking cholangiocarcinoma and neck malignancy is it been of CBD in 
An immortalized rat pancreatic stellate cell line RP-2 as a new cell model for evaluating pancreatic fibrosis,inflammation and immunity被引量:6
《Hepatobiliary & Pancreatic Diseases International》2015年第6期651-659,共9页Rong-Li Piao Ming Xiu David R Brigstock Run-Ping Gao 
support by grants from the National Natural Science Foundation of China(81070370 and 81270544)
BACKGROUND: Pancreatic stellate cells (PSCs) play a critical role in the pathogenesis of pancreatic fibrosis and have emerging functions as progenitor cells, immune cells or intermediaries in pancreatic exocrine se...
关键词:pancreatic stellate cell pancreatic fibrosis Toll-like receptor 4 INFLAMMATION IMMUNITY 
LPS-TLR4信号通路在慢性酒精摄入大鼠模型肝纤维化发生中的作用及其机制被引量:5
《吉林大学学报(医学版)》2015年第4期751-755,I0003,I0004,共7页杨坤 田珍珍 王淑华 修明 郭乡羚 齐丽娜 李敏 孙丽 高润平 
国家自然科学基金资助课题(81270544)
目的:通过检测慢性酒精摄入大鼠门静脉血中内毒素脂多糖(LPS)水平,探讨LPS-Toll样受体4(TLR4)通路在慢性酒精摄入大鼠模型肝纤维化发生中的作用及意义。方法:24只雄性SD大鼠随机分为酒精组和对照组,分别喂养等热量的Lieber-Decarli酒精...
关键词:脂多糖 TOLL样受体4 肝脏星状细胞 肝纤维化 乙醇 
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