云南高校图书馆联盟文献共享服务平台- 国家重点基础研究发展计划(2013CB932501)

国家重点基础研究发展计划(2013CB932501): 作品数：15被引量：63H指数：2; 导出分析报告; 相关作者：齐宪荣张烜张强吕万良仰浈臻更多>>; 相关机构：北京大学常德职业技术学院更多>>; 相关期刊：《Journal of Chinese Pharmaceutical Sciences》《中国药学杂志》《药学研究》《中国新药杂志》更多>>; 相关主题：CONJUGATEPACLITAXEL脂质体TPGSEPIRUBICIN更多>>; 相关领域：医药卫生更多>>

康普瑞汀脂质体体外抗乳腺癌拟态血管的作用被引量：1: 《中国药学杂志》2018年第4期278-282,共5页刘汉黄丹郭阳张烜; 国家重点基础研究计划973资助项目(2013CB932501); 目的考察康普瑞汀(combretastatin A4,CA4)脂质体(SSL-CA4)体外抗拟态血管(vascular mimicry,VM)的作用。方法选择CA4为模型药物,构建SSL-CA4。选择MDA-MB-231乳腺癌为细胞模型,考察SSL-CA4对MDA-MB-231细胞的生长抑制作用、对MDA-MB-23...; 关键词：康普瑞汀脂质体 MDA-MB-231细胞拟态血管抗肿瘤作用

Characterization of amphiphilic dendrimer modified PEG-PLA nanoparticles prepared by a double emulsion-solvent evaporation method: 《Journal of Chinese Pharmaceutical Sciences》2017年第7期521-527,共7页李欣庞宁李骥齐宪荣; National Natural Science Foundation of China(Grant No.81473156,81673365,81273454);Doctoral Foundation of the Ministry of Education(Grant No.20130001110055);National Key Basic Research Program(Grant No.2013CB932501); Drug delivery by nanocarriers requires characterizations of suitable particle size, high drug loading and safety. In this work, we prepared an amphiphilic dendrimer modified PEG-PLA mixed nanoparticles（NPs） by a dou...; 关键词：PEG-PLA nanoparticles DOCETAXEL PACLITAXEL Double emulsion-solvent evaporation method Amphiphilic dendrimer

A novel type of functional epirubicin liposomes modified with DSPE-PEG_(2000)-cyclopamine conjugate for eliminating heterogeneous breast cancer cells: 《Journal of Chinese Pharmaceutical Sciences》2017年第4期255-264,共10页胡英杰张靖莹刘磊阎妍沐黎敏白婧吴佳栓吕万良; National Basic Research Program of China(973 Program,Grant No.2013CB932501);the National Science Foundation of China(Grant No.81373343,81673367); Common chemotherapy is unable to eliminate the heterogeneous side population of cancer cells （such as cancer stem-like cells）, resulting in poor prognosis. The heterogeneity of cancer cells causes an extensive multi...; 关键词：Cyclopamine conjugate Epirubin Liposomes HETEROGENEITY Breast cancer

In vitro comparative evaluation of three CLD/siRNA nanoplexes prepared by different processes被引量：2: 《Journal of Chinese Pharmaceutical Sciences》2016年第9期660-668,共9页Chong Qiu Shihe Cui Jing Sun Jiancheng Wang; National Basic Research Program of China(973 program,Grant No.2013CB932501);the National Natural Science Foundation of China(Grant No.81273455,81473158 and 81573374);Programs of Ministry of Education of China(Grant No.NCET-11-0014 and BMU20110263); In this study, a gemini-like cationic lipid （CLD） was used as the carrier to study the complexation features of CLD/ siRNA nanoplexes （CLD/siRNA NPs）. Three types of CLD/siRNA nanoplexes （named as AT NPs, HT NPs ...; 关键词：SIRNA Delivery NANOPARTICLES Preparation Cellular uptake

The use of a new functional glucose conjugate material, TPGS_(1000)-Glu, in treatment of brain glioma by incorporating into epirubicin liposomes被引量：2: 《Journal of Chinese Pharmaceutical Sciences》2016年第4期266-274,共9页沐黎敏吴佳栓谢红军刘磊曾凡阎妍赵曜胡英杰卜英子吕万良; National Basic Research Program of China(973 Program,Grant No.2013CB932501);Beijing Natural Science Foundation(Grant No.7131009);National Natural Science Foundation of China(Grant No.81373343); Most of antieancer agents can not be used for treatment of brain glioma due to the existence of the blood brain barrier （BBB）. The over-expression of glucose transporters （GLUTs） on the BBB and brain glioma cells ...; 关键词：TPGS1000-Glu EPIRUBICIN Liposomes Glucose transporters Brain glioma

The targeting effect of H_7K(R_2)_2-modified pH-sensitive liposomes on U87-MG cells: 《Journal of Chinese Pharmaceutical Sciences》2015年第10期660-665,共6页赵阳任伟钟婷王超张卫强黄丹张爽郭阳姚鑫张烜张强; Specialized Research Fund for the Doctoral Program of Higher Education(Grant No.20120001110012);the National Basic Research Program of China(973 Program,Grant No.2013CB932501);National Natural Science Foundation of China(Grant No.81172992); The present study aimed to investigate the targeting effect of H7K（R2）2-modified pH -sensitive liposomes on U87-MG cells. Using coumarin-6 as a fluorescence probe, we prepared H7K（R2）2-modified p H-sensitive lipos...; 关键词：H7K（R2）2-modified pH-sensitive liposomes Cellular uptake pathway Secondary structure U87-MG cells

Folate and cell penetrating peptide modification effects on penetration behavior of nanostructured lipid carriers using multicellular tumor spheroids被引量：1: 《Journal of Chinese Pharmaceutical Sciences》2015年第10期666-672,共7页庄鸿蒙孟婷婷高玮袁兰齐宪荣; National key Basic Research Program(Grant No.2013CB932501);National Natural Science Foundation of China(Grant No.81273454 and 81473156);Beijing National Science Foundation(Grant No.7132113);Doctoral Foundation of the Ministry of Education(Grant No.20130001110055); Surface modification may have important influences on the penetration behavior of nanoscale drug delivery system. In the present study, we mainly focused on whether cell targeting or cell penetration could affect pene...; 关键词：Nanostructured lipid carriers Multicellular tumor spheroids Stacking method Folate Cell penetrating peptide

Vapreotide-modified nanomicelle as a targeted nanocarrier for delivering paclitaxel to the tumors with overexpression of somatostatin receptors: 《Journal of Chinese Pharmaceutical Sciences》2015年第8期501-513,共13页Wenjie Hou Hua Zheng Jiancheng Wang; National Basic Research Program of China(973 Program,Grant No.2013CB932501);NSFC projects(Grant No.81273455 and 81473158);Programs from Ministry of Education(Grant No.NCET-11-0014 and BMU20110263); Somatostatin receptors （SSTRs） were widely expressed in many tumor cells. As a somatostatin analogue, vapreotide （VAP） can be exploited as a modifier for targeting tumor therapy based on its high affinity to SSTR....; 关键词：Somatostatinreceptor Vapreotide Targeted nanomicelle PACLITAXEL Tumor therapy

Preparation and anti-MDR tumors study of folate and TPGS dual-modified DSPE-PEG micelles loaded with docetaxel被引量：1: 《Journal of Chinese Pharmaceutical Sciences》2015年第7期419-426,共8页王爱婷佟淑文胡新齐宪荣; National Natural Science Foundation of China(Grant No.81273454 and 81473156);Beijing National Science Foundation(Grant No.7132113);National Key Basic Research Program(Grant No.2013CB932501);Doctoral Foundation of the Ministry of Education(Grant No.20130001110055); Multidrug resistance （MDR） operated by P-glycoprotein （P-gp） is one of the major causes in the treatment failure of cancers. In this work, docetaxel-loaded mixed micelles comprised of 1,2-distearoyl-sn-glycero-3-p...; 关键词：Micelles Multidrug resistance PREPARATION DSPE-PEG TPGS Folate

Targeting glioblastoma cancer stem cell marker CD133 by heptapeptidemodified DSPE-PEG micelles: 《Journal of Chinese Pharmaceutical Sciences》2015年第1期34-39,共6页王景达何冰代文兵王学清王坚成张烜张强; The Key Program of National Science Foundation(Grant No.81130059);the National Basic Research Program of China(Grant No.973 program,2013CB932501); Cancer stem cells have become the new target of chemotherapy with specific cell marker. CD133 is shown to be highly expressed in glioma cancer stem cells. In this study, a drug delivery system is designed to target CD...; 关键词：Cancer stem cell CD 133 TR peptide MICELLE Tumorsphere FACS

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