国家自然科学基金(90913022)

作品数：4被引量：8H指数：2
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相关作者：章永登吴政星冯婉娟徐涛周围更多>>
相关机构：华中科技大学中国科学院更多>>
相关期刊：《Science China(Life Sciences)》《Science China Chemistry》《生物化学与生物物理进展》《Protein & Cell》更多>>
相关主题：OXIDASEMETALLOPROTEINSEXPANDINGMYOGLOBINRATIONAL更多>>
相关领域：生物学建筑科学核科学技术电气工程更多>>
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Functional tuning and expanding of myoglobin by rational protein design被引量：4
《Science China Chemistry》2014年第3期346-355,共10页LIN YingWu WANG JiangYun LU Yi 
supported by the National Natural Science Foundation of China(21101091,31370812);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education of China.J.Wang is supported by the National Basic Research Program of China(2010CB912301,2009CB82 5505);the National Natural Science Foundation of China(90913022);Y.Lu is supported by the US National Institute of Health(GM062211)
Rational protein design is a powerful strategy,not only for revealing the structure and function relationship of natural metalloproteins,but also for creating artificial metalloproteins with improved properties and fu...
关键词：METALLOPROTEINS heme proteins protein design OXIDASE REDUCTASE 
Ultrafast,accurate,and robust localization of anisotropic dipoles被引量：3
《Protein & Cell》2013年第8期598-606,共9页Yongdeng Zhang Lusheng Gu Hao Chang Wei Ji Yan Chen Mingshu Zhang Lu Yang Bei Liu Liangyi Chen Tao Xu 
We thank L.L.Looger(Janelia Farm Research Campus)for providing the mEos2 cDNA and Toshio Yanagida(Osaka University,Japan)for sharing the Q rods.This work was supported by grants from the National Basic Research Program(973 Program)(Nos.2010CB833701 and 2010CB912303);the National Key Technology R&D Program(SQ2011SF11B01041);the National Natural Science Foundation of China(Grant Nos.31130065,31170818,90913022,31127901,and 31100615);the Beijing Natural Science Foundation(7121008);the Chinese Academy of Sciences Project(KSCX1-1W-J-3,KSCX2-EWQ-11,and 2009-154-27).
The resolution of single molecule localization imaging techniques largely depends on the precision of localization algorithms.However,the commonly used Gaussian function is not appropriate for anisotropic dipoles beca...
关键词：point spread function restricted mobility artifi cial neural network super-resolution imaging 
UNC-10在致密核心囊泡分泌过程中的作用(英文)
《生物化学与生物物理进展》2012年第6期556-562,共7页冯婉娟 周围 章永登 吴政星 徐涛 
supported by grants from National Basic Research Program of China(2010CB833701);The National Natural Science Foundation of China(30870564,90913022);Key Inndvative Project of Chinese Academy of Sciences(KSCX2-SW-224)~~
Rim是囊泡分泌活性区中的重要组成蛋白,它与细胞分泌和突触可塑性相关.在秀丽隐感线虫中只存在一种编码Rim的基因即unc-10.我们的研究发现,在线虫中Rim的基因突变unc-10(md1117)会导致致密核心囊泡的分泌缺陷.在活体中,unc-10突变虫系...
关键词：秀丽隐杆线虫 致密核心囊泡 UNC-10 细胞分泌 
RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C.elegans被引量：1
《Science China(Life Sciences)》2012年第3期228-235,共8页FENG Wan Juan LIANG Tao YU JunWei ZHOU Wei ZHANG YongDeng WU ZhengXing XU Tao 
supported by the National Basic Research Program of China(Grant No. 2010CB833701);the National Natural Science Foundation of China(Grant Nos. 30870564 and 90913022);the CAS Project(Grant No.KSCX2-SW-224)
The molecular mechanisms by which dense core vesicles(DCVs) translocate,tether,dock and prime are poorly understood.In this study,Caenorhabditis elegans was used as a model organism to study the function of Rab protei...
关键词：EXOCYTOSIS dense core vesicles RAB-3 RAB-27 C. elegans total internal reflection fluorescence microscopy 
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