Chronic periodontitis is a disease of public health concern due to its high prevalence globally, especially in the elderly. The aim of this study was to determine the impact of non-surgical periodontal therapy on sali...
In the construction of biosensors, enzymes function as mediators converting biological signals generated by specific biological processes, into electrochemical signals. The ideology of bio-sensor design is retention o...
supported by the US National Science Foundation(CHE-1413328);the Major State Basic Research Program of China(2015CB856203);the National Natural Science Foundation of China (21325211,31500641);theTianjinMunicipalGrant(13ZCZDSY04800, 14ZCZDSY00059,14JCYBJC43400)
Metalloproteins have inspired chemists for many years to synthesize artificial catalysts that mimic native enzymes.As a complementary approach to studying native enzymes or making synthetic models,biosynthetic approac...
Cells contain a large number of metalloproteins that commonly harbor at least one metal ion cofactor. In metalloproteins, metal ions are usually coordinated by oxygen, sulfur, or nitrogen centers belonging to amino ac...
supported by the National Natural Science Foundation of China(21101091,31370812);the Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education of China.J.Wang is supported by the National Basic Research Program of China(2010CB912301,2009CB82 5505);the National Natural Science Foundation of China(90913022);Y.Lu is supported by the US National Institute of Health(GM062211)
Rational protein design is a powerful strategy,not only for revealing the structure and function relationship of natural metalloproteins,but also for creating artificial metalloproteins with improved properties and fu...
Project (No. 2011-II-010) supported by the Fundamental Research Funds for the Central Universities,China
Various molecular docking software packages are available for modeling interactions between small molecules and proteins.However,there have been few reports of modeling the interactions between metal ions and metallop...
supported by the National Natural Science Foundation of China(21133005 and 20703022)
The microscopic mechanisms of ion hydration and ion selectivity in biomolecular systems are long-standing research topics, in which the difficulty is how to reasonably and accurately describe the ion-water and ion-bio...
Supported by the National Natural Science Foundation of China (Grant No. 20771029);Shanghai Pujiang Talent Project (Grant No. 08PJ14017);Shanghai Leading Academic Discipline Project (Grant No. B108)
This paper focuses on the group of metalloproteins/metalloenzymes in the acetyl-coenzyme A synthesis pathway of anaerobic microbes called Wood-Ljungdahl pathway,including formate dehydrogenase (FDH),corrinoid iron sul...
A method using synchrotron radiation X-ray fluorescence analysis toin situ determine trace elements during protein electrophoretically separating process was established. The distribution of elements in protein bands ...