the National Natural Science Foundation of China(No.52173124);the Fundamental Research Funds for the Central Universities(No.2172019kfyXJJS070).
Bacterial infections exacerbate the formation of bacterial biofilms,leading to resistance to traditional drugs,persistent infection,and even threatening patient’s life.Efficient antimicrobial materials against drug-r...
In this study, we exhibited an amino acid (arginine and threonine) derivative Schiff base copper(II) complexes incorporating an azobenzene moiety as a photoresponsive site and conjugated it to egg white lysozyme, a we...
supported by the National Natural Science Foundation of China (Grant No. 31771407);the Natural Science Foundation of Guangdong Province, China (Grant Nos. 2015A030313555 and 2019A1515011938);the Science and Technology Innovation Committee of Shenzhen Municipality, China (Grant No. JCYJ20180305124023495);the Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, China (Grant No. 2019SHIBS0003)
Trace elements are required by all organisms,which are key components of many enzymes catalyzing important biological reactions.Many trace element-dependent proteins have been characterized;however,little is known abo...
In the construction of biosensors, enzymes function as mediators converting biological signals generated by specific biological processes, into electrochemical signals. The ideology of bio-sensor design is retention o...
Objective: To study the effects of operation combined with chemotherapy on MMP-2, TIMP-1, VEGF, NSE, LDH and immunologic function in children with neuroblastoma (NB). Methods: A total of 90 children with NB in our hos...
Supported by the National Natural Science Foundation of China,No.81071241
AIM: To compare the effect of transarterial chemoembolization(TACE) plus GRGDSP(Gly-Arg-Gly-Asp-SerPro, integrin-inhibitor) loaded nanoparticles with TACE alone or TACE + GRGDSP in a rat model of liver tumor. METHODS:...
This work was supported by the grants from the National Natural Science Foundation of China (No. 81300787), the Natural Science Foundation of Jiangsu Province (Nos. BK2012105 and BK20141103), the Project of Jiangsu Provincial Commission of Health and Family Planning (No. H201546), the Major Project of Wuxi Municipal Health Bureau (Nos. ZS201401, Z201508, and MS201404), and the Project of Wuxi Municipal Science and Technology Bureau (No. CSE31N1520).
Carcinoma-associated fibroblasts (CAFs) play central roles in facilitating tumor progression and metastasis in breast cancer. Galectin-1 (Gal-1), a marker of CAFs, was previously reported to be associated with tum...
Cells contain a large number of metalloproteins that commonly harbor at least one metal ion cofactor. In metalloproteins, metal ions are usually coordinated by oxygen, sulfur, or nitrogen centers belonging to amino ac...
supported by the National Natural Science Foundation of China (Nos.21272186 and 81361138018)
In an effort to understand the recombination of a B2 metallo-β-lactamase(MβL),the binding of metals to apo-ImiS was studied by isothermal titration calorimetry and fluorescence spectra.The binding of Zn(Ⅱ),Co...
We present a simple method for direct detection of hydrogen sulfide (H2S) in an aqueous solution. This method represents a novel biosensor based on metalloprotein cytoehrome c (cyt c) with the localized surface pl...