supported by grants the Nano Material Technology Development Program(NRF-2021M3H4A1A04092879)through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT;the Materials and Parts Technology Development Program(20023353);Advanced Technology Center(ATC+,20017939)funded by the Ministry of Trade,Industry&Energy(MOTIE,Korea).
Modulating inflammatory cells in an implantation site leads to severe complications and still unsolved challenges for blood-contacting medical devices.Inspired by the role of galectin-1(Gal-1)in selective functions on...
Oxidative stress is characterized by the deregulation of the redox state in the cells,which plays a role in the initiation of various types of cancers.The activity of galectin-1(Gal-1)depends on the cell redox state a...
The authors are grateful to all of the patients who participated in the study.We thank Prof Dalong Ma Lab and Prof Wenling Han Lab at Peking University Health Science Center for providing plasmids and helpful discussions.We also thank the Center for Biomarker Discovery and Validation,National Infrastructures for Translational Medicine(PUMCH),Institute of Clinical Medicine,Peking Union Medical College Hospital for instrument support and assistance.This study was supported by grants from the National Natural Science Foundation of China(81788101,82171799,82100942,82171726,82171798,82230060,32141004);National Key R&D Program of China(2022YFC3602000);Chinese Academy of Medical Science Innovation Fund for Medical Sciences(2021-I2M-1-017,2022-I2M-JB-003,2021-I2M-1-047,2021-I2M-1-040,2021-I2M-1-016,and 2021-I2M-1-026);Capital’s Funds for Health Improvement and Research(2020-2-4019);National High Level Hospital Clinical Research Funding(BJ-2022-116,BJ-2023-084).
Inhibitory immune receptors set thresholds for immune cell activation,and their deficiency predisposes a person to autoimmune responses.However,the agonists of inhibitory immune receptors remain largely unknown,repres...