国家自然科学基金(20721003)

作品数：8被引量：19H指数：2
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相关机构：中国科学院广州市药品检验所上海海洋大学中国科学院上海生命科学研究院更多>>
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The essential role for aromatic cluster in the β3 adrenergic receptor
《Acta Pharmacologica Sinica》2012年第8期1062-1068,共7页Hai-yan CAI Zhi-jian XU Jie TANG Ying SUN Kai-xian CHEN He-yao WANG Wei-liang ZHU 
This work was supported by grants from the National Natural Science Foundation of China （20721003, 81072681）, the Inter-national S＆T Cooperation（2010DFB73280）, and the Shanghai Committee of Science and Technology International Coopera-tion Project （09540703900）.
Aim： To explore the function of the conserved aromatic cluster F213^5.47, F308^6.51, and F309^6.52 in human β3 adrenergic receptor （hβ3AR）. Methods： Point mutation technology was used to produce plasmid mutation...
关键词：β3 adrenergic receptor constitutive activity MUTATION aromatic residue G protein-coupled receptors 
Synthesis of α-substituted β-amino acids via the Ni(II) complex through the Suzuki coupling reaction
《Journal of Chinese Pharmaceutical Sciences》2012年第6期561-568,共8页吕丽 王江 丁晓 林岱宗 赵临襄 蒋华良 柳红 
National Basic Research Program of China (Grants No. 2009CB940903 and 2009CB918502);the National Natural Science Foundation of China (Grant No. 20721003 and 81025017);National S&T Major Projects (Grant No. 2012ZX09103-101-072).
A convenient and efficient method for the preparation of α-substituted β-amino acids has been developed by reacting compound 2 with various boric acid/borate 3 through Suzuki coupling reaction,which gave multiple st...
关键词：Ni（II） complex Suzuki coupling reaction α-Substituted β-amino acids 
SmI_2-promoted imino-Reformatsky reaction for facile synthesis of enantioenriched β-amino acid esters
《Science China Chemistry》2011年第1期61-65,共5页WANG Li SHEN Chun XU Ming-Hua 
Financial support from the National Natural Science Foundation of China (20721003);the Chinese Academy of Sciences, the State Key Laboratory of Drug Research, SIMM and National Science & Technology Major Project (2009ZX09301-001 & 2008ZX09401-004) is acknowledged
A facile and efficient method for the stereoselective synthesis of β-amino acid esters via SmI2-promoted imino-Reformatsky reaction is described.Asymmetric addition of tert-butyl bromoacetate to N-tert-butanesulfinyl...
关键词：β-amino acid ester samarium diiodide N-tert-butanesulfinyl imine Reformatsky reaction Β-LACTAM 3-aminoindan-1-one asymmetric synthesis 
中国南海短指软珊瑚Sinularia sp.的化学成分研究(英文)
《中国海洋药物》2010年第6期7-11,共5页贾睿 严小红 何培民 郭跃伟 
supported by National Science & Technology Major Project(2009ZX09301-001);Natural Science Foundation of China(Nos.21072204,30730108,and 20721003);STCSM International Cooperation Project between SIMM/China and ICB/Italy(No.10540702900);Science Foundation for the Excellent Youth Scholars of Shanghai(ssc09001);Scientific Research Foundation for PhD of Shanghai Ocean University;partly founded by the NSFC-TRF International Cooperation Project(No.20911140471)
目的研究南海短指软珊瑚的化学成分。方法综合利用各种层析方法分离和纯化化合物,并利用光谱学和理化性质来鉴定化合物结构。结果从中分离得到8个甾体化合物,分别鉴定为24-methylcholesta-5,24(28)-diene-3β,7β3,19-triol(1)、24-meth...
关键词：短指软珊瑚 化学成分 甾体 
扭曲肉芝软珊瑚的化学成分(英文)被引量：1
《中国天然药物》2010年第6期422-424,共3页贾睿 施艳红 何培民 郭跃伟 
supported by the National Science & Technology Major Project (No 2009ZX09301-001);Natural Science Foundation of China (Nos 21072204, 30730108 and 20721003);Science Foundation for the Excellent Youth Scholars of Shanghai (No ssc09001);STCSM International Cooperation Project between SIMM/China and ICB/Italy (No 10540702900);NSFC-TRF International Cooperation Project (No 20911140471);the CAS Key Project (grant KSCX2-YW-R-18)~~
目的:研究扭曲肉芝软珊瑚的化学成分。方法:综合利用各种层析方法分离和纯化化合物, 并利用光谱学和理化性质来鉴定化合物结构。结果:从中分离得到5个化合物, 分别鉴定为 brassicolide (1), emblide (2),methyl tortuoate A (3), methyl...
关键词：扭曲肉芝软珊瑚 化学成分 二聚西松烷四萜 
中国东海冈村凹顶藻 Laurencia okamurai 中的倍半萜类成分（英文）被引量：1
《中国天然药物》2010年第5期321-325,共5页毛水春 郭跃伟 
This project was supported by the National Science & Technology Major Project (No. 2009ZX09301-001);Natural Science Foundation of China (Nos. 40976048,30730108 and 20721003);STCSM International Cooperation Project between SIMM/China and ICB/Italy (No. 10540702900);partly founded by the NSFC-TRF International Cooperation Project (No. 20911140471)~~
目的:对采自中国东海的红藻冈村凹顶藻 Laurencia okamurai 的化学成分进行研究, 从中寻找具有生物活性的次生代谢产物。方法:运用硅胶柱层析和凝胶柱层析对冈村凹顶藻的乙醚提取物进行分离纯化; 根据其理化性质, 结合现代波谱分析技术(...
关键词：红藻 冈村凹顶藻 倍半萜 结构解析 
南海中华小尖柳珊瑚Muricella sinensis化学成分的研究被引量：10
《有机化学》2008年第7期1264-1267,共4页严小红 李震宇 郭跃伟 
国家海洋863计划(Nos.2006AA09Z447,2006AA09Z412,2007AA09Z447);国家自然科学基金(Nos.20572116,30730108,20721003);上海市科委基础研究(Nos.07XD14036,06DZ22028);中国科学院重点(No.KSCX2-YW-R-18)资助项目
从采自中国南海的中华小尖柳珊瑚(Muricella sinensis)中分离得到了1个新的Eunicellane型二萜,命名为sinensin(1),和6个已知化合物:13-去乙酰氧基calicophirin B(2),calicophirin B(3),calicophirin C(4),astrogorgin(5),calicoferol E...
关键词：柳珊瑚 Muricella SINENSIS Eunicellane型二萜 
Natural product juglone targets three key enzymes from Helicobacter pylori： inhibition assay with crystal structure characterization被引量：7
《Acta Pharmacologica Sinica》2008年第7期870-876,共7页Yun-hua KONG Liang ZHANG Zheng-yi YANG Cong HAN Li-hong HU Hua-liang JIANG Xu SHEN 
This work was supported by the National Natural Science Foundation of China （No 30525024, 20721003, and 90713046）.
Aim： To investigate the inhibition features of the natural product juglone （5- hydroxy-1,4-naphthoquinone） against the three key enzymes from Helicobacter pylori （cystathionine γ-synthase [HpCGS], malonyl-CoA：ac...
关键词：cystathionine γ-synthase malonyl-CoA：acyl carrier protein transacylase β-hydroxyacyl-ACP dehydratase inhibitor type complex structure 
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