国家重点基础研究发展计划(2010CB934000)

作品数：4被引量：9H指数：2
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相关作者：陆伟跃李翀沈洁更多>>
相关机构：复旦大学西南大学更多>>
相关期刊：《中国科学：化学》《Science China Chemistry》《Asian Journal of Pharmaceutical Sciences》《Science Bulletin》更多>>
相关主题：MULTIDRUG_RESISTANCEMDRCANCERNANOTECHNOLOGYMULTIDRUG更多>>
相关领域：医药卫生化学工程更多>>
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Nanocarriers for siRNA delivery to overcome cancer multidrug resistance被引量：1
《Chinese Science Bulletin》2013年第33期4021-4030,共10页MENG QingShuo YIN Qi LI YaPing 
supported by the National Basic Research Program of China(2010CB934000,2012CB932502,2013CB932503);the National Natural Science Foundation of China(30925041,81270047);Shanghai Elitist Program(11XD1406200)
Multidrug resistance(MDR)is an extremely complexed phenomenon in tumor chemotherapy and is one of the major obstacles for successful treatment.Discovery of RNA interference(RNAi)offers a new strategy with great potent...
关键词：siRNA 纳米载体 递送 耐药性 癌症 阳离子聚合物 多药耐药 RNAI 
Folic acid-conjugated liposomal vincristine for multidrug resistant cancer therapy被引量：3
《Asian Journal of Pharmaceutical Sciences》2013年第2期118-127,共10页Chenyu Wang Linglin Feng Xiangkun Yang Fei Wang Weiyue Lu 
This work was supported by National Science and Technology Major Project(2012ZX09304004);National Basic Research Program of China(973 Program,2010CB934000);National Natural Science Foundation of China(81072593,81102402);Specialized Research Fund for the Doctoral Program of Higher Education(20110071130011).
We encapsulated vincristine into folic acid-conjugated PEGylated liposomes to improve the anti-tumor efficacy on multidrug resistant cancers.It was observed that the drug delivery system we constructed exhibited maxim...
关键词：Multidrug resistance Folic acid LIPOSOME VINCRISTINE Targeting delivery PHARMACODYNAMICS 
镜像配基筛选:克服“酶屏障”的多肽、寡核苷酸药物研发技术
《中国科学：化学》2011年第7期1112-1120,共9页李翀 沈洁 陆伟跃 陆五元 
国家重点基础研究发展计划(973计划)(2007CB935800和2010CB934000);西南大学博士基金(SWU110028);西南大学基本科研业务费专项资金项目(XDJK2009C077)资助
生物体内存在的"酶屏障"是功能性多肽和寡核苷酸成药的重要瓶颈.以镜像噬菌体展示技术(mirror-image phage display)和镜像适配体筛选技术(Spiegelmer technology)为代表的镜像配基筛选技术能有效地克服这一屏障,获得对靶点具有特异识...
关键词：镜像噬菌体展示技术 镜像适配体筛选技术 D型多肽 L型寡核苷酸 
Overcoming multidrug resistance(MDR) in cancer by nanotechnology被引量：5
《Science China Chemistry》2010年第11期2226-2232,共7页BU HuiHui,GAO Yu & LI YaPing Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203,China 
The National Basic Research Program of China (2010CB934000);the National Natural Science Foundation of China (30925041);Shanghai Nanomedicine Program (0852nm05700)
The emerging nanotechnology-based drug delivery holds tremendous potential to deliver chemotherapeutic drugs for treatment of multidrug resistance(MDR) cancer.This drug delivery system could improve the pharmacokineti...
关键词：NANOTECHNOLOGY nanoparticles MULTIDRUG resistance CHEMOTHERAPEUTIC drugs CANCER drug delivery system 
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