国家重点基础研究发展计划(2007CB914804)

作品数：6被引量：34H指数：4
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相关作者：孙蕾魏晓丽王青山王悦郑慧琳更多>>
相关机构：南开大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《Science Bulletin》《中华医学杂志》更多>>
相关主题：HBXHEPATOMAMUTANT转录激活因子5-LIPOXYGENASE更多>>
相关领域：生物学农业科学医药卫生更多>>
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A mutant of hepatitis B virus X protein （HBx△127） enhances hepatoma cell migration via osteopontin involving 5-1ipoxygenase被引量：4
《Acta Pharmacologica Sinica》2010年第5期593-600,共8页Xuan ZHANG Li-hong YE Xiao-dong ZHANG 
Acknowledgements This project was supported by grants from the National Basic Research Program of China （973 Program, No 2007CB914802, No 2007CB914804, No 2009CB521702） and the National Natura,1 Science Foundation （No 30670959）.
Aim： To explore a novel function of a mutant of the hepatitis B virus X protein （HBx△127） in the promotion of hepatoma cell migration. Methods： The effect of HBx△127 and wild type HBx on the migration ability of...
关键词：hepatitis B virus X protein mutant of HBx cell migration OSTEOPONTIN HEPATOMA 5-1ipoxygenase 
A mutant of HBx （HBxΔ127） promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase被引量：8
《Acta Pharmacologica Sinica》2010年第3期367-374,共8页Qi WANG Wei-ying ZHANG Li-hong YE Xiao-dong ZHANG 
Acknowledgments This work was supported by grants from the National Basic Research Program of China （No 973 Program, No 2007CB914804, No 2007CB914802, No 2009CB521702） and the National Natural Science Foundation of China （No 30670959）.The authors thank Dr Q LIU （University of Saskatchewan, Canada） for providing the plasmids： pFAS-WT-Luc, pFAS-ΔSRE–Luc, and SREBP-1c-571-Luc-WT.
Aim： Previously, we identified a natural mutant of hepatitis B virus X gene （HBx） with a deletion from 382 to 401 base pairs （termed HBxΔ127）, which could potently enhance growth of hepatoma cells. In this study...
关键词：HBxΔ127 proliferation sterol response element binding protein-1c fatty acid synthase 5-LIPOXYGENASE 
Impact of STAT4 gene silencing on the expression profile of proteins in EL-4 cells被引量：4
《Chinese Science Bulletin》2009年第18期3265-3270,共6页WEI XiaoLi NI Hong WANG QingShan XIANG Rong WANG Yue 
Supported by the National Key Basic Research and Development Program of China (Grant No. 2007CB914804);National High Technology Research and Development Program of China (Grant No. 2007AA021010);Foundation of the Ministry of Education of China for Returned Scholars;Key Project of the Science & Technology Pillar Program of Tianjin (Grant No. 07ZCKFSH03700);Innovative Research Foundation of Nankai University
The signal transducers and activators of transcription (STATs) have diverse biological functions and are involved in cell differentiation, proliferation, development, apoptosis and inflammation. Several constitutively...
关键词：细胞分化 细胞蛋白 表达谱 基因沉默 转录激活因子 转化生长因子 肿瘤细胞 发光 
Transformation of human liver L-02 cells mediated by stable HBx transfection被引量：7
《Acta Pharmacologica Sinica》2009年第8期1153-1161,共9页Wei-ying ZHANG Na CAI Li-hong YE Xiao-dong ZHANG 
Acknowledgements This project was supported by grants from the National Basic Research Program of China （973 Program, No 2007CB914802, No 2007CB914804, No 2009CB521702） and the National Natural Science Foundation （No 30670959）.
Aim： To explore the mechanism of hepatocarcinogenesis associated with the hepatitis B virus X protein （HBx）, we investigated the role of HBx in transformation using human liver L-02 cells stably transfected with HB...
关键词：HBX TRANSFORMATION HEPATOMA genomic instability stable transfection 
探讨沉默信号转导与转录激活因子-4及细胞因子信号负调控因子-3对辅助性T细胞分化的影响被引量：5
《中华医学杂志》2009年第17期1197-1202,共6页孙蕾 魏晓丽 王青山 郑慧琳 向荣 王悦 
国家重点基础研究计划基金（2007CB914804）;国家高技术研究发展计划基金（2007AA021010）;教育部留学归国科研基金;天津市科技支撑计划重点项目（07ZCKFSH03700）
目的探讨沉默信号转导与转录激活因子_4（STAT4）及细胞因子信号负调控因子-3（SOCS3）后对白细胞介素（IL）-12及IL4诱导的辅助性T（Th）淋巴细胞分化中的影响以及对于Th1及Th2细胞亚群分泌细胞因子的影响。方法以IL-12和IL-4分别诱导...
关键词：辅助性T细胞 细胞分化 转录激活因子 信号负调控因子 
Gene expression profiles of human liver cells mediated by hepatitis B virus X protein被引量：7
《Acta Pharmacologica Sinica》2009年第4期424-434,共11页Wei-ying ZHANG Fu-qing XU Chang-liang SHAN Rong XIANG Li-hong YE Xiao-dong ZHANG 
This project was supported by grants from the National Basic Research Program of China （973 Program, No 2007CB914802, No 2007CB914804, No 2009CB521702）, Chinese State Key Projects for High-Tech 863 Program （2006AA02A247）,and the National Natural Science Foundation （No 30670959）.
Aim： To demonstrate the gene expression profiles mediated by hepatitis B virus X protein （HBx）, we characterized the molecular features of pathogenesis associated with HBx in a human liver cell model. Methods： We ...
关键词：hepatitis B virus HBX MICROARRAY COX-2 PROLIFERATION 
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