国家自然科学基金(31370949)

作品数：6被引量：35H指数：4
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相关作者：王贵学童建华张康唐朝君邱菊辉更多>>
相关机构：重庆大学同济大学更多>>
相关期刊：《Regenerative Biomaterials》《医用生物力学》《中国动脉硬化杂志》更多>>
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Effect of intraplaque angiogenesis to atherosclerotic rupture-prone plaque induced by high shear stress in rabbit model被引量：13
《Regenerative Biomaterials》2017年第4期215-222,共8页Juhui Qiu Daoxi Lei Jianjun Hu Tieying Yin Kang Zhang Donghong Yu Guixue Wang 
This research program was supported by grants from the National Natural Science Foundation of China(31370949,11332003,111572064);Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology(ChongqingUniversity),Ministry of Education(CQKLBST-2014-008);the Fundamental Research Funds for the Central Universities(106112016CDJXZ238802);as well as the Public Experiment Center of State Bioindustrial Base(Chongqing),China.
Atherosclerotic prone-rupture plaque is mainly localized in the region of the entrance to the stenosiswith high shear stress and the reasons are largely unknown. Our hypothesis is that such a distributionof cells in a...
关键词：ANGIOGENESIS ATHEROSCLEROSIS shear stress prone-rupture plaque 
Cytotoxic effects of docetaxel as a candidate drug of drug-eluting stent on human umbilical vein endothelial cells and the signaling pathway of cell migration inhibition,adhesion delay and shape change被引量：2
《Regenerative Biomaterials》2017年第3期167-178,共12页Tingzhang Hu Chun Yang Meiling Fu Jiali Yang Rolin Du Xiaolin Ran Tieying Yin Guixue Wang 
The study was supported by grants from the National Natural Science Foundation of China(11332003,31370949 and 81400329);the National Key Technology R&D Program of China(2016YFC1102305 and 2012BAI18B02);the Chongqing Graduate Student Research Innovation Project(CYS14023);the Fundamental Research Funds for the Central Universities(106112016CDJXZ238802);as well as the support from the Chongqing Engineering Laboratory in Vascular Implants and the Public Experiment Center of State Bioindustrial Base(Chongqing),China.
Docetaxel(DTX),a paclitaxel analogue,can efficiently inhibit proliferation of vascular smooth muscle cells and has broadly been used as an antiangiogenesis drug.However,as a candidate drug of drug-eluting stent,the ef...
关键词：cytotoxic effects DOCETAXEL endothelial cells signaling pathway 
腹主动脉瘤生物力学研究的新进展被引量：5
《医用生物力学》2016年第5期369-375,共7页童建华 王贵学 
同济大学青年优秀人才培养计划(1500219086);中央高校基本科研业务费(1500219085,1500219095);重庆大学生物流变科学与技术教育部重点实验室访问学者基金(CQKLBST-2016-010);国家自然科学基金项目(31370949)
腹主动脉瘤(abdominal aortic aneurysm,AAA)是腹主动脉局部呈肿瘤状扩张的血管疾病。如果不及时治疗,持续扩张的AAA将最终破裂,具有极高的死亡率。近年来,生物力学方法被广泛地应用于AAA临床破裂风险的评估预测中。相关研究成果也极大...
关键词：腹主动脉瘤 生物力学特性 血栓 破裂风险预测 有限元分析 
High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis被引量：12
《Regenerative Biomaterials》2016年第4期257-267,共11页Yi Wang Juhui Qiu Shisui Luo Xiang Xie Yiming Zheng Kang Zhang Zhiyi Ye Wanqian Liu Hans Gregersen GuixueWang 
This research program was supported by grants from the National Natural Science Foundation of China(31370949,11332003,81400329 and 11372364);Chongqing Science and Technology Commission(cstc2013kjrc-ljrccj10003)as well as the Public Experiment Center of State Bioindustrial Base(Chongqing),China.
Rupture of atherosclerotic plaques causing thrombosis is the main cause of acute coronary syndrome and ischemic strokes.Inhibition of thrombosis is one of the important tasks developing biomedical materials such as in...
关键词：high shear stress ANGIOGENESIS outward remodelling vulnerable plaque vascular smooth muscle cells 
Distinctive effects of CD34- and CD133-specific antibody-coated stents on re-endothelialization and in-stent restenosis at the early phase of vascular injury被引量：8
《Regenerative Biomaterials》2015年第2期87-96,共10页Xue Wu Tieying Yin Jie Tian Chaojun Tang Junli Huang Yinping Zhao Xiaojuan Zhang Xiaoyan Deng Yubo Fan Donghong Yu Guixue Wang 
This study was partially supported by grants-in-aid from the National Natural Science Foundation of China(11332003,31370949);the National Key Technology R&D Program of China(2012BAI18B02);the National Key Basic Research Program of China(2012CB619101)。
It is not clear what effects of CD34-and CD133-specific antibody-coated stents have on reendothelialization and in-stent restenosis(ISR)at the early phase of vascular injury.This study aims at determining the capabili...
关键词：STENT CD133 CD34 endothelial progenitor cells RE-ENDOTHELIALIZATION 
分化抑制因子调控血管新生参与易损斑块形成的力生物学机制
《中国动脉硬化杂志》2013年第9期I0014-I0014,共1页凌博 邱菊辉 张康 尹铁英 唐朝君 张筱娟 王贵学 
国家自然科学基金项目（31370949,11332003）;国家科技支撑计划项目（2012BAll8802）
目的本研究旨在了解分化抑制因子（Idl）参与切应力和脂蛋白调控血管新生的作用，为阐明狭窄血管近心端的高切应力通过刺激内皮细胞血管新生进而引起易损斑块形成及其分子机制提供科学依据。方法采用小鼠左颈总动脉狭窄模型．给小鼠饲...
关键词：动脉粥样硬化 易损斑块 血管新生 分化抑制因子 血管内皮生长因子 
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