国家自然科学基金(30225017)

作品数:3被引量:0H指数:0
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相关作者:李艳贺芳夏梁何大澄曾长青更多>>
相关机构:北京协和医院北京师范大学中国科学院更多>>
相关期刊:《Science China(Life Sciences)》《Journal of Genetics and Genomics》更多>>
相关主题:蛋白质组分HAPMAPGENE_ONTOLOGYCONSTRUCTINGAUTOIMMUNE更多>>
相关领域:医药卫生生物学电子电信更多>>
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Constructing an initial map of transmission distortion based on high density HapMap SNPs across the human autosomes
《Journal of Genetics and Genomics》2009年第12期703-709,共7页Libin Deng Dake Zhang Elliott Richards Xiaoli Tang Jin Fang Fei Long Yan Wang 
supported by the National Nature Science Foundation of China (No.30225017)
Transmission distortion (TD) is a significant departure from Mendelian predictions of genes or chromosomes to offspring. While many biological processes have been implicated, there is still much to be understood abo...
关键词:transmission distortion HapMap Project gene ontology 
Identification of new centrosome proteins by autoimmune patient sera
《Science China(Life Sciences)》2007年第2期194-202,共9页XIA Liang1, LI Yan1, YANG Dong1, WANG LiMin1, HE Fang1, ZHOU ChunYuan1, LI YongZhe2, ZENG ChangQing1 & He DaCheng1 1 Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, Beijing Normal University, Beijing 100875, China 2 Peking Union Medical Hospital, Peking Union Medical College, Beijing 100730, China 3 Beijing Genomic Institute, Beijing 101300, China 
the special fundations of Ministry of Education of China and National Natural Science Foundation of China (Grant No. 30225017)
Compared to other subcellular organelles, centrosome proteome can hardly be studied, due to the dif- ficulties in separation and purification of centrosome. Auto-antisera from 6 autoimmune patients, which recognized c...
关键词:CENTROSOME AUTOIMMUNE PATIENT SERA ELUTION of antibody immunoflourescence IMMUNOPRECIPITATION mass spectrometry 
利用自身免疫病人血清鉴定新的中心体蛋白质组分
《中国科学(C辑)》2006年第5期432-440,共9页夏梁 李艳 杨栋 王丽敏 贺芳 周春媛 李永哲 曾长青 何大澄 
教育部专项基金;国家自然科学基金(批准号:30225017)
与其他亚细胞结构相比,中心体由于其分离和纯化方面的困难使其蛋白质组学研究一直处于滞后状态.通过免疫荧光证明特异性识别中心体的6名自身免疫病人的自发抗血清被用来鉴定它们相应的抗原即中心体蛋白.利用细胞全蛋白的Western blot检...
关键词:中心体 自身免疫病人血清 抗体洗脱 免疫荧光 免疫沉淀 质谱 
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