Introduction: During pregnancy, the increased demand for all the nutrients required for the development of the foetus means that the maternal stock of trace elements and minerals may become unbalanced if dietary intak...
approved by the Research Ethics Committees of Zhejiang Provincial People’s Hospital(No.QT2022387).
Pancreatic cancer is among the most malignant cancers,and thus early intervention is the key to better survival outcomes.However,no methods have been derived that can reliably identify early precursors of development ...
3-甲基戊烯二酸尿症伴耳聋、脑病和Leigh样综合征(3-methylglutaconic aciduria with deafness,encephalopathy and leigh-like syndrome,MEGDEL综合征)(OMIM:614739)为SERAC1基因变异所致累及多系统的一种罕见特异性线粒体疾病,遗传方...
supported in part by grants from the National Medical Research Council(COVID19RF-001,COVID19RF-003,COVID19RF-0008,COVID19RF-0014,COVID19RF-0018,COVID19RF3-0060,MOH-000535/MOH-OFYIRG19nov-0002 and MOH-000505-02);SingHealth Duke-NUS Academic Medicine COVID-19 Rapid Response Research Grant(AM/COV001/2020);Collaborative Research Fund(C2103-20GF);Wellcome COVID-19 Grant on Understanding the Biological Significance SARS-CoV-2 Variants(226120/Z/22/Z);National Institute of Health NIAID(R01AI163118 and 5U01AI151797);National Public Health COVID Program of the Government of Monaco.
Multiple Omicron sub-lineages have emerged,with Omicron XBB and XBB.1.5 subvariants becoming the dominant variants globally at the time of this study.The key feature of new variants is their ability to escape humoral ...
This work was supported by the Basic and Applied Basic Research Foundation of Guangdong province(No.2019A1515011928).
Background:Although antinuclear antibodies(ANAs),anti‐SSA and anti‐Ro52,are present in immunoglobulin preparations,it is unknown whether intravenous immunoglobulin(IVIG)therapy influences the testing of serum autoan...
supported by the National Natural Science Foundation of China(No.U20A20392);the 111 Project(No.D20028);Open Research Fund Program of the Key Laboratory of Molecular Biology for Infectious Diseases,China(No.CQMU202102 and CQMU202105);The Science and Technology Research Program of Chongqing Municipal Education Commission,China(No.KJZD-M202000401);The Natural Science Foundation Project of Chongqing,China(No.cstc2019jscx-dxwtBX0019);The Emergency Project from the Science&Technology Commission of Chongqing,China(No.cstc2020jscx-fyzx0053 and cstc2020jscx-dxwtB0050);Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University,the Emergency Project for Novel Coronavirus Pneumonia from the Chongqing Medical University,China(No.CQMUNCP0302);China Postdoctoral Science Foundation,China(No.2021M693924);Chongqing Postdoctoral Science Special Foundation,China(No.2010010005216630).
Coronavirus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The Spike protein that mediates coronavirus entry into host cells is a major target for COVID-19 vaccines and ...
supported by the National Natural Science Foundation of China(Grant Nos.31970708,81770147,81802891,and 82002953);the National Scientific and Technological Major Special Project of China(Grant No.2019ZX09201004-002-013);the National Thirteenth Five-Year Science and Technology Major Special Project for New Drug Innovation and Development(Grant No.2017ZX09304001);the Research fund of Shanghai Municipal Commission of Health(Grant No.20174Y0090);the Shanghai Rising-Star Program(Grant No.18QA1404100);the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning;the Shanghai Youth Talent Program;the Shanghai Municipal Key Clinical Specialty(Grant No.shslczdzk03701);the Three-Year Plan of Shanghai Municipality for Further Accelerating The Development of Traditional Chinese Medicine[Grant No.ZY(20182020)-CCCX-1016];the Shanghai Chenguang Program(Grant No.18CG47);the grant from Nantong Tumor Hospital(Grant No.BS201909);the Gaofeng Clinical Medicine Grant of Shanghai Municipal Education Commission;the Health Commission of Pudong New Area Health and Family Planning Scientific Research Project(Grant No.PW2019E-1);the Xinling Scholar Program of Shanghai University of Traditional Chinese Medicine,China。
Esophageal squamous cell carcinoma(ESCC)is a major histological subtype of esophageal cancer with a poor prognosis.Although several serum metabolomic investigations have been reported,ESCC tumor-associated metabolic a...
supported by the China National Major Scientific and Technological Special Project for“Significant New Drugs Innovation and Development”(Grant No.:2019ZX09732002-006);the National New Drug Creation Program of China(Grant No.:2018ZX09201017-004);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.:XDA12020223,XDA12020330,XDA12020360,and XDA12050305);the National Natural Science Foundation of China(Grant Nos.:81872785 and 81673347);the Science and Technology Planning Projects of Department of Science and Technology Province(Grant No.:20190202);Shanghai Municipal Commission of Science and Technology of China(Grant Nos.:17431904400,19YF1457400,and 21S11904500);Institutes for Drug Discovery and Development,the Chinese Academy of Sciences(Grant Nos.:CASIMM0120202007 and CASIMM0120202008);Major Scientific and Technological Special Project of Zhongshan City(Grant Nos.:191022172638719 and 210205143867019).
Antibody-drug conjugates(ADCs)are commonly heterogeneous and require extensive assessment of exposure-efficacy and exposure-safety relationships in preclinical and clinical studies.In this study,we report the generati...