SERA

作品数:119被引量:350H指数:8
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相关领域:医药卫生更多>>
相关作者:王明山潘景业王晓蓉黄跃跃王卫更多>>
相关机构:温州医学院附属第一医院广西大学清华大学北京大学更多>>
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相关基金:国家自然科学基金国家高技术研究发展计划中国博士后科学基金美国中华医学基金会项目更多>>
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Trace Element Concentrations in the Sera of Pregnant Women in Kisangani, Democratic Republic of Congo
《Journal of Biosciences and Medicines》2025年第2期218-229,共12页Likilo Osundja Jérémie Komanda Likwekwe Emmanuel Tshodi Bulanda Arsène Juakali Sihalikyolo Jean-Jeannot Buhendwa Mirindi Victor Katenga Bosunga Gédéon 
Introduction: During pregnancy, the increased demand for all the nutrients required for the development of the foetus means that the maternal stock of trace elements and minerals may become unbalanced if dietary intak...
关键词:Trace Element Zinc Copper SELENIUM CALCIUM Magnesium Pregnant Woman SERUM Kisangani 
Mass spectrometry analysis of intact protein N-glycosylation signatures of cells and sera in pancreatic adenocarcinomas
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第1期51-64,共14页Mingming XU Zhaoliang LIU Wenhua HU Ying HAN Zhen WU Sufeng CHEN Peng XIA Jing DU Xumin ZHANG Piliang HAO Jun XIA Shuang YANG 
approved by the Research Ethics Committees of Zhejiang Provincial People’s Hospital(No.QT2022387).
Pancreatic cancer is among the most malignant cancers,and thus early intervention is the key to better survival outcomes.However,no methods have been derived that can reliably identify early precursors of development ...
关键词:Pancreatic cancer GLYCOSYLATION Biomarker GLYCOPROTEOMICS Mass spectrometry 
3-甲基戊烯二酸尿症伴耳聋、脑病和Leigh样综合征1例临床特征和基因变异分析
《长治医学院学报》2023年第6期455-457,共3页李慧琴 崔心怡 张嘉秀 崔清洋 
3-甲基戊烯二酸尿症伴耳聋、脑病和Leigh样综合征(3-methylglutaconic aciduria with deafness,encephalopathy and leigh-like syndrome,MEGDEL综合征)(OMIM:614739)为SERAC1基因变异所致累及多系统的一种罕见特异性线粒体疾病,遗传方...
关键词:MEGDEL综合征 SERAC1基因 纯合变异 无义变异 
SERAC1基因变异致MEGDEL综合征2例并文献回顾
《中华医学遗传学杂志》2023年第9期1100-1106,共7页林晓霞 林希 严争 陈燕惠 陈珊 
国家重点研发计划(2016YFC1306204);福建省自然科学基金(2020J011177)。
目的探讨2例SERAC1基因变异所致的MEGDEL综合征患儿的临床表型及遗传学特点。方法以2020年7月14日与2018年7月28日就诊于福建医科大学附属协和医院儿科的2例MEGDEL综合征患儿作为研究对象。回顾分析患儿的临床资料及基因检测结果,并对ME...
关键词:MEGDEL综合征 Leigh样综合征 3-甲基戊烯二酸尿症 SERAC1基因 基因变异 
Distinctive serotypes of SARS-related coronaviruses defined by convalescent sera from unvaccinated individuals被引量:5
《hLife》2023年第1期26-34,共9页Chee Wah Tan Feng Zhu Wan Ni Chia #Barnaby EYoung Aileen Ying Yan Yeoh Thomas Althaus Chee Fu Yung Wee Chee Yap Beng Lee Lim Mark I-C Chen Jinyan Zhang Yun Yan Mah Eric Voiglio Alex Sigal Jianxin Huo Shengli Xu Yee Joo Tan Kong-Peng Lam David Lye Lin-Fa Wang 
supported in part by grants from the National Medical Research Council(COVID19RF-001,COVID19RF-003,COVID19RF-0008,COVID19RF-0014,COVID19RF-0018,COVID19RF3-0060,MOH-000535/MOH-OFYIRG19nov-0002 and MOH-000505-02);SingHealth Duke-NUS Academic Medicine COVID-19 Rapid Response Research Grant(AM/COV001/2020);Collaborative Research Fund(C2103-20GF);Wellcome COVID-19 Grant on Understanding the Biological Significance SARS-CoV-2 Variants(226120/Z/22/Z);National Institute of Health NIAID(R01AI163118 and 5U01AI151797);National Public Health COVID Program of the Government of Monaco.
Multiple Omicron sub-lineages have emerged,with Omicron XBB and XBB.1.5 subvariants becoming the dominant variants globally at the time of this study.The key feature of new variants is their ability to escape humoral ...
关键词:SARS-CoV-2 SARS-CoV-1 SEROTYPE Omicron primary infection convalescent sera 
Transient positive antimitochondrial M2 in sera of patients with connective tissue diseases after intravenous immunoglobulin infusions被引量:1
《Rheumatology & Autoimmunity》2022年第4期230-236,共7页Lijuan Yang Xiuning Wei Qianhua Li Honggui Li Zhiming Ouyang Aiqi Zeng Donghui Zheng Lie Dai Yingqian Mo 
This work was supported by the Basic and Applied Basic Research Foundation of Guangdong province(No.2019A1515011928).
Background:Although antinuclear antibodies(ANAs),anti‐SSA and anti‐Ro52,are present in immunoglobulin preparations,it is unknown whether intravenous immunoglobulin(IVIG)therapy influences the testing of serum autoan...
关键词:antimitochondrial M2 antinuclear antibodies connective tissue disease intravenous immunoglobulins 
La coopération maritime sera un nouveau point de croissance
《今日中国(法文版)》2022年第12期36-37,共2页
Reduced neutralization of SARS-CoV-2 B.1.617 variant by convalescent and vaccinated sera被引量:1
《Genes & Diseases》2022年第5期1290-1300,共11页Jie Hu Xiao-yu Wei Jin Xiang Pai Peng Feng-li Xu Kang Wu Fei-yang Luo Ai-shun Jin Liang Fang Bei-zhong Liu Kai Wang Ni Tang Ai-Long Huang 
supported by the National Natural Science Foundation of China(No.U20A20392);the 111 Project(No.D20028);Open Research Fund Program of the Key Laboratory of Molecular Biology for Infectious Diseases,China(No.CQMU202102 and CQMU202105);The Science and Technology Research Program of Chongqing Municipal Education Commission,China(No.KJZD-M202000401);The Natural Science Foundation Project of Chongqing,China(No.cstc2019jscx-dxwtBX0019);The Emergency Project from the Science&Technology Commission of Chongqing,China(No.cstc2020jscx-fyzx0053 and cstc2020jscx-dxwtB0050);Kuanren Talents Program of the second affiliated hospital of Chongqing Medical University,the Emergency Project for Novel Coronavirus Pneumonia from the Chongqing Medical University,China(No.CQMUNCP0302);China Postdoctoral Science Foundation,China(No.2021M693924);Chongqing Postdoctoral Science Special Foundation,China(No.2010010005216630).
Coronavirus disease 2019(COVID-19)is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The Spike protein that mediates coronavirus entry into host cells is a major target for COVID-19 vaccines and ...
关键词:CORONAVIRUS Immune escape Mutation Neutralizing antibodies SARS-CoV-2 VACCINE Viral entry 
New Metabolic Alterations and A Predictive Marker Pipecolic Acid in Sera for Esophageal Squamous Cell Carcinoma
《Genomics, Proteomics & Bioinformatics》2022年第4期670-687,共18页Lei Liu Jia Wu Minxin Shi Fengying Wang Haimin Lu Jibing Liu Weiqin Chen Guanzhen Yu Dan Liu Jing Yang Qin Luo Yan Ni Xing Jin Xiaoxia Jin Wen-Lian Chen 
supported by the National Natural Science Foundation of China(Grant Nos.31970708,81770147,81802891,and 82002953);the National Scientific and Technological Major Special Project of China(Grant No.2019ZX09201004-002-013);the National Thirteenth Five-Year Science and Technology Major Special Project for New Drug Innovation and Development(Grant No.2017ZX09304001);the Research fund of Shanghai Municipal Commission of Health(Grant No.20174Y0090);the Shanghai Rising-Star Program(Grant No.18QA1404100);the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning;the Shanghai Youth Talent Program;the Shanghai Municipal Key Clinical Specialty(Grant No.shslczdzk03701);the Three-Year Plan of Shanghai Municipality for Further Accelerating The Development of Traditional Chinese Medicine[Grant No.ZY(20182020)-CCCX-1016];the Shanghai Chenguang Program(Grant No.18CG47);the grant from Nantong Tumor Hospital(Grant No.BS201909);the Gaofeng Clinical Medicine Grant of Shanghai Municipal Education Commission;the Health Commission of Pudong New Area Health and Family Planning Scientific Research Project(Grant No.PW2019E-1);the Xinling Scholar Program of Shanghai University of Traditional Chinese Medicine,China。
Esophageal squamous cell carcinoma(ESCC)is a major histological subtype of esophageal cancer with a poor prognosis.Although several serum metabolomic investigations have been reported,ESCC tumor-associated metabolic a...
关键词:Esophageal squamous cell carcinoma Serum metabolome ESOPHAGECTOMY Predictive potential Pipecolic acid 
Enzyme-linked immunosorbent assays for quantification of MMAE-conjugated ADCs and total antibodies in cynomolgus monkey sera
《Journal of Pharmaceutical Analysis》2022年第4期645-652,共8页Min Pei Tingting Liu Lu Ouyang Jianhua Sun Xiaojie Deng Xiaomin Sun Wei Wu Peng Huang Yi-Li Chen Xiaorong Tan Xiaoyue Liu Peng Zhu Yongzhen Liu Deheng Wang Junliang Wu Qi Wang Guifeng Wang Likun Gong Qiuping Qin Chunhe Wang 
supported by the China National Major Scientific and Technological Special Project for“Significant New Drugs Innovation and Development”(Grant No.:2019ZX09732002-006);the National New Drug Creation Program of China(Grant No.:2018ZX09201017-004);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant Nos.:XDA12020223,XDA12020330,XDA12020360,and XDA12050305);the National Natural Science Foundation of China(Grant Nos.:81872785 and 81673347);the Science and Technology Planning Projects of Department of Science and Technology Province(Grant No.:20190202);Shanghai Municipal Commission of Science and Technology of China(Grant Nos.:17431904400,19YF1457400,and 21S11904500);Institutes for Drug Discovery and Development,the Chinese Academy of Sciences(Grant Nos.:CASIMM0120202007 and CASIMM0120202008);Major Scientific and Technological Special Project of Zhongshan City(Grant Nos.:191022172638719 and 210205143867019).
Antibody-drug conjugates(ADCs)are commonly heterogeneous and require extensive assessment of exposure-efficacy and exposure-safety relationships in preclinical and clinical studies.In this study,we report the generati...
关键词:Monomethyl auristatin E Antibody-drug conjugates PHARMACOKINETICS Trophoblast cell surface antigen 2 
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