《Journal of Genetics and Genomics》

作品数：4060被引量：25745H指数：53
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《Journal of Genetics and Genomics》
主办单位：中国科学院遗传与发育生物学研究所;中国遗传学会
最新期次：2025年2期更多>>
发文主题：英文水稻小麦RICE染色体更多>>
发文领域：生物学农业科学医药卫生文化科学更多>>
发文作者：朱立煌吴常信张亚平陈佩度李宁更多>>
发文机构：中国科学院遗传与发育生物学研究所中国科学院南京农业大学华中农业大学更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划国家教育部博士点基金更多>>
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TMEM39A and TMEM131 facilitate bulk transport of ECM proteins through large COPII vesicle formation
《Journal of Genetics and Genomics》2025年第2期189-203,共15页Jee Young Sung Ga-Eun Lim Jarim Goo Kyung Jin Jung Jeong Min Chung Hyun Suk Jung Yong-Nyun Kim Jaegal Shim 
supported by the National Institutes of Health-Office of Research Infrastructure Programs(P40 OD010440);supported in part by grants from the National Cancer Center of Korea(NCC-2110160,NCC-2110263,and NCC-2310750);supported by the Basic Science Research Program of the National Research Foundation of Korea,funded by the Ministry of Science,ICT,and Future Planning(NRF-2015R1C1A1A01053611).
The growth of Caenorhabditis elegans involves multiple molting processes,during which old cuticles are shed and new cuticles are rapidly formed.This process requires the regulated bulk secretion of cuticle components....
关键词：Bulk secretion COLLAGEN COPII ECM TMEM39A TMEM131 
Integrated analysis and systematic characterization of the regulatory network for human germline development
《Journal of Genetics and Genomics》2025年第2期204-219,共16页Yashi Gu Jiayao Chen Ziqi Wang Qizhe Shao Zhekai Li Yaxuan Ye Xia Xiao Yitian Xiao Wenyang Liu Sisi Xie Lingling Tong Jin Jiang Xiaoying Xiao Ya Yu Min Jin Yanxing Wei Robert S.Young Lei Hou Di Chen 
supported by the National Natural Science Foundation of China awarded to D.C.(32270835);Zhejiang Natural Science Foundation awarded to D.C.(Z22C129553);Dr.Li Dak Sum&Yip Yio Chin Development Fund for Regenerative Medicine,Zhejiang University,awarded to D.C.
Primordial germ cells(PGCs)are the precursors of germline that are specified at the embryonic stage.Recent studies reveal that humans employ different mechanisms for PGC specification compared with model organisms suc...
关键词：Primordial germ cells Regulatory network Soma-germ cell interaction DATABASE 
Wnt2bb signaling promotes pharyngeal chondrogenic precursor proliferation and chondrocyte maturation by activating Yap expression in zebrafish
《Journal of Genetics and Genomics》2025年第2期220-230,共11页Xiaojuan Guo Liping Yang Yujie Wang Mengna Yuan Wenqing Zhang Xinyu He Qiang Wang 
support of the National Natural Science Foundation of China(32025014 and 32330029 to Q.W.);the National Key Research and Development Program of China(2020YFA0804000 to Q.W.);Guangdong Excellent Youth Team Project(2024B1515040019 to Q.W.);Guangzhou Science and Technology Plan Project(202201010323 to X.H.);the Fundamental Research Funds for the Central Universities(to Q.W.).
Pharyngeal cartilage morphogenesis is crucial for the formation of craniofacial structures.Cranial neural crest cells are specified at the neural plate border,migrate to pharyngeal arches,and differentiate into pharyn...
关键词：Wnt/β-catenin signaling YAP Wnt2bb Chondrocyte maturation Pharyngeal cartilage ZEBRAFISH 
Integrated analysis reveals that miR-548ab promotes the development of obesity and T2DM
《Journal of Genetics and Genomics》2025年第2期231-244,共14页Chongge Pan Yali Hou Yanting Hou Ruizhen Wang Meiyu Qian Xue Bai Maodi Liang Jingzhou Wang Jie Liu Qianqian Wei Ziyan Pan Ting Wang Chenyu Hu Kun Xiang Chun Yang Cuizhe Wang Hua Chen Jun Zhang 
supported by the Natural Science Foundation of China(82160156,82260162,and 32370669);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB38040200);the Tianshan Talent Project in Xinjiang Autonomous Region(2023TSYCCX0116 and 2023TSYCQNTJ0032);the Scientific and Technological Research Project of Xinjiang Production and Construction Corps(2022ZD001,2021AB028,2022AB022,2023AB057,and 2023ZD037).
Dysregulation of microRNA(miRNA)expression following the development of obesity is closely linked to the onset of type 2 diabetes mellitus(T2DM).Identifying differentially expressed miRNAs and their roles in regulatin...
关键词：OBESITY miR-548ab GULP1 and SLC25A21 Glucose metabolism T2DM 
Genomic insights into demographic history,structural variation landscape,and complex traits from 514 Hu sheep genomes
《Journal of Genetics and Genomics》2025年第2期245-257,共13页Kaiyu Chen Yuelang Zhang Yizhe Pan Xin Xiang Chen Peng Jiayi He Guiqing Huang Zhengguang Wang Pengju Zhao 
supported by grants from the Zhejiang Science and Technology Department Project(2023C04004);Zhejiang Science and Technology Major Program on Agricultural New Variety Breeding(2021C02068-6);Department of Science Technology of Huzhou City(2023GZ33);Zhejiang Team Technology Ambassador Project(Tongxiang);the National Natural Science Foundation of China(32172724).
Hu sheep is an indigenous breed from the Taihu Lake Plain in China,known for its high fertility.Although Hu sheep belong to the Mongolian group,their demographic history and genetic architecture remain inconclusive.He...
关键词：Hu sheep Population sequencing Demographic history Structural variation Genome-wide association study 
PAMPHLET:PAM Prediction HomoLogous-Enhancement Toolkit for precise PAM prediction in CRISPR-Cas systems
《Journal of Genetics and Genomics》2025年第2期258-268,共11页Chen Qi Xuechun Shen Baitao Li Chuan Liu Lei Huang Hongxia Lan Donglong Chen Yuan Jiang Dan Wang 
supported by grants from the Foundation for Distinguished Young Talents in Higher Education of Guangdong,China(2024KQNCX157);Our work was also supported in part by the Guangdong Provincial Key Laboratory of Interdisciplinary Research and Application for Data Science,BNU-HKBU United International College(2022B1212010006);in part by the Guangdong Higher Education Upgrading Plan(2021-2025)of“Rushing to the Top,Making Up Shortcomings and Strengthening Special Features”(R0400001-22);Additionally,we acknowledge support from the Zhuhai Basic and Applied Basic ResearchFoundation(2220004002717).
CRISPR-Cas technology has revolutionized our ability to understand and engineer organisms,evolving from a singular Cas9 model to a diverse CRISPR toolbox.A critical bottleneck in developing new Cas proteins is identif...
关键词：CRISPR-Cas Protospacer adjacentmotif Genome editing PAM prediction Computational framework 
Improved chromosome-level donkey(Equus asinus)genome provides insights into genome and chromosome evolution
《Journal of Genetics and Genomics》2025年第2期269-272,共4页Ge Yang Mian Gong Qi-Meng Yang Yi-Dan Li Halima Jafari Chu-Zhao Lei Yu Jiang Rui-Hua Dang 
supported by the Third National Census of Livestock and Poultry Genetic Resources(K4050422227);the 2020 Scientist plus Engineer program of Shaanxi Province of China;the Central Guidance on Local Science and Technology Development Fund(K3030922098).
The donkey is an important livestock species that can provide milk,meat,and skin and belongs to the family Equus.The first genome of a male donkey was sequenced and de novo assembled using a whole-genome shotgun strat...
关键词：INSIGHT belongs 
Epigenetic control of plant abiotic stress responses
《Journal of Genetics and Genomics》2025年第2期129-144,共16页Lijun Ma Lihe Xing Zicong Li Danhua Jiang 
supported by the National Key R&D Program of China(2023YFD1200704);the intramural research support from Temasek Life Sciences Laboratory.
On top of genetic information,organisms have evolved complex and sophisticated epigenetic regulation to adjust gene expression in response to developmental and environmental signals.Key epigenetic mechanisms include D...
关键词：PLANT EpigeneticslGene expressionlAbiotic stresslEnvironmental memory 
Improving regulatory T cell-based therapy:insights into post-translational modification regulation
《Journal of Genetics and Genomics》2025年第2期145-156,共12页Aiting Wang Yanwen Wang Rui Liang Bin Li Fan Pan 
supported by grants from the National Key R&D Program of China(2022YFC2403000 and 2021YFC2400500);the National Natural Science Foundation of China(32200728 and 32170925);the Clinical Research Project of Shenzhen Medical Academy of Research and Translation(C2301008);Shenzhen Science and Technology Program(JCYJ20220531100406014,JCYJ2022081800807016,RCBS20221008093336088,KQTD20210811090115019);Guangdong Basic and Applied Basic Research Foundation(2021A1515110375);the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20210601).
Regulatory T(Treg)cells are pivotal for maintaining immune homeostasis and play essential roles in various diseases,such as autoimmune diseases,graft-versus-host disease(GVHD),tumors,and infectious diseases.Treg cells...
关键词：Treg cell FOXP3 UBIQUITINATION ACETYLATION PHOSPHORYLATION METHYLATION GLYCOSYLATION Post-translational modification 
Activation ofγ-globin expression by a common variant disrupting IKAROS-binding motif inβ-thalassemia
《Journal of Genetics and Genomics》2025年第2期157-167,共11页Hualei Luo Jueheng Wang Lang Qin Xinhua Zhang Hailiang Liu Chao Niu Mengyang Song Congwen Shao Peng Xu Miao Yu Haokun Zhang Yuhua Ye Xiangmin Xu 
supported by the National Natural Science Foundation of China(U20A20353 to X.Xu and 81900185 to Y.Ye).
Programmed silencing ofγ-globin genes in adult erythropoiesis is mediated by several chromatin remodeling complexes,which determine the stage-specific genome architecture in this region.Identification of cis-or trans...
关键词：Β-THALASSEMIA Fetal hemoglobin Single nucleotidepolymorphism IKAROS Locus control region 
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