云南高校图书馆联盟文献共享服务平台- Journal of Intensive Medicine

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Safety and efficacy of selective RIPK1 inhibitor SIR1-365 in hospitalized patients with severe COVID-19:A multicenter,randomized,double-blind,phase 1b trial: 《Journal of Intensive Medicine》2025年第1期70-78,共9页Norberto Chavez-Tapia Muneeba Ahsan Sayeed Shobha Luxmi Douglas J.Kasper Fenchao Xue Yang Shen Weiliang Fan Wei Yuan Bin Du; Background:Receptor-interacting protein kinase 1(RIPK1),a serine/threonine protein kinase,is mainly activated by pro-inflammatory cytokines and pathogens,including severe acute respiratory syndrome coronavirus 2(SARS-...; 关键词：COVID-19 Phase 1b trial Receptor-interacting protein 1 RIPK1 RIPK1 inhibitor SIR1-365

Intestine-derived fibroblast growth factor 19 alleviates lipopolysaccharide-induced liver injury by regulating bile acid homeostasis and directly improving oxidative stress: 《Journal of Intensive Medicine》2025年第1期79-88,共10页Xiaomeng Tang Jingjing Ning Yilin Zhao Shuyun Feng Lujing Shao Tiantian Liu Huje Miao Yucai Zhang Chunxia Wang; supported by the National Natural Science Foundation of China(grant number:82171729);the Natural Science Foundation of Shanghai(grant number:23ZR1453000);the Shanghai Municipal Health Commission(grant number:202340076);the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant(grant number:20171928).; Background:Cholestasis plays a critical role in sepsis-associated liver injury(SALI).Intestine-derived fibroblast growth factor 19(FGF19)is a key regulator for bile acid homeostasis.However,the roles and underlying me...; 关键词：FGF19 Bile acid OXIDATIVESTRESS Mitochondria dysfunction Acuteliver injury SEPSIS

Overexpression of Parkin promotes the protective effect of mitochondrial autophagy on the lung of rats with exertional heatstroke: 《Journal of Intensive Medicine》2025年第1期89-99,共11页Ran Meng Zhengzhong Sun Ruxue Chil Yan Gu Yuxiang Zhang Jiaxing Wang; supported by the 2020 Special Tasks for Military Health and Epidemic Prevention and Protection(grant number Hou Wei Han[2021]No.208);Hospital Project(grant number 2016ZD-008).; Background:The roles of the Pink1/Parkin pathway and mitophagy in lung injury during heat stroke remain unclear.In this study,we investigated the role of Pink1/Parkin-mediated mitophagy in acute lung injury(ALI)in rat...; 关键词：Exertional heat stroke Acutelung injury MITOPHAGY PINK1 PARKIN

Influence of hydrocortisone infusion method on the clinical outcome of patients with septic shock: A systematic review and meta-analysis: 《Journal of Intensive Medicine》2025年第1期100-107,共8页Yuting Li Youquan Wang Jianxing Guo Dong Zhang; supported by institutional research funding provided by the National Key R&D Program of China,Ministry of Science and Technology of the People's Republic of China(grant numbers:2022YFC2304605,2022YFC2304604);Clinical Applied Research and Medical Training Fund of China Primary Health Care Foundation(grant number:so20220722jl);Wu Jieping Medical Foundation(grant number:320.6750.2023-03-11).; Background:The effect of the modality of hydrocortisone administration on clinical outcomes in patients with septic shock remains uncertain. This systematic review and meta-analysis evaluate the impact of intermittent...; 关键词：SEPSIS TIME NOREPINEPHRINE Septic shock Treatment outcome

Metabolomic profiling and prognostication in CoVID-19 acute respiratory distress syndrome: 《Journal of Intensive Medicine》2025年第1期108-110,共3页David Furfaro Xiaoyu Che Wenhao Gou Matthew J.Cummings Nischay Mishra Daniel Brodie Thomas Briese Oliver Fiehn W.Ian Lipkin Max R.O'Donnell; CHEST Foundation Grant in COVID-192020(DMF).; To the Editor,Coronavirus disease 2019(COVID-19)-related acute respiratory distress syndrome(ARDS)is biologically and clinically heterogeneous with a broad spectrum of organ dysfunction and illness severity.[1] In COV...; 关键词：DISTRESS ACUTE Metab

Critical Care Almanac:Annual Innovations and Achievements: 《Journal of Intensive Medicine》2025年第1期1-2,共2页Changsong Wang Dechang Chen; In the current era,with rapid advancements in medical technology and an aging population,critical care medicine stands as a shining star within the medical field,its significance growing ever more prominent.The global...; 关键词：strengthening EDUCATION ACCOMPLISHMENT

New drugs for acute kidney injury: 《Journal of Intensive Medicine》2025年第1期3-11,共9页Geoffroy Hariri Matthieu Legrand; Acute kidney injury(AKI)presents a significant challenge in the management of critically ill patients,as it is as-sociated with increased mortality,prolonged hospital stays,and increased healthcare costs.In certain co...; 关键词：Acutekidney injury DRUGS Criticalcare Innovative therapies Targeted care

Nebulized aminoglycosides for ventilator-associated pneumonia:Methodological considerations and lessons from experimental studies: 《Journal of Intensive Medicine》2025年第1期12-22,共11页Jean-Jacques Rouby Jing Xia Jayesh Dhanani Gianluigi Li Bassi Antoine Monsel Antoni Torres on behalf of the European Investigators Network for Nebulized Antibiotics in Ventilator-associated Pneumonia(ENAVAP); Aminoglycosides are concentration-dependent antibiotics exerting a bactericidal effect when concentrations at the site of infection are equal to or greater than 5 times the minimum inhibitory concentrations(MIC).When ...; 关键词：AMINOGLYCOSIDES Ventilator-associated pneumonia Nebulized amikacin Nebulized tobramycin Lung microdialysis Experimental intensive care unit

Current advances in neurocritical care: 《Journal of Intensive Medicine》2025年第1期23-31,共9页Yuqing Chen Shuya Wang Shanshan Xu Ningyuan Xu Linlin Zhang Jianxin Zhou; This review summarizes the current research advances and guideline updates in neurocritical care. For the therapy of ischemic stroke, the extended treatment time window for thrombectomy and the emergence of novel thro...; 关键词：Neurocritical care Intracerebral hemorrhage Traumaticbrain injury Subarachnoid hemorrhage Cardiac arrest Endovascular therapy

The pros and cons of beta-blockers in sepsis:Where do we stand in 2024?: 《Journal of Intensive Medicine》2025年第1期32-34,共3页Daniel De Backer Dechang Chen; Septic shock is associated with severe vasoplegia, increased permeability, maldistribution of regional blood flows, and microvascular alterations. Hemodynamic management includes fluid and vasopressor agents and, in s...; 关键词：TACHYCARDIA ELEVATED SEPSIS

《Journal of Intensive Medicine》