Alzheimer Society UK.UK Dementia Research Institute(DRIEdi17/18MRC MC_PC_17113);British Heart Foundation(CS/15/5/31475);The Stroke Association.Mrs Gladys Row Fogo Charitable Trust(AD.ROW4.35D.FID3668413);Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces.Alzheimer’s Research UK.UK Medical Research Council.
Cerebral small vessel disease(cSVD)causes lacunar stroke(25%of ischaemic strokes),haemorrhage,dementia,physical frailty,or is‘covert’,but has no specific treatment.Uncertainties about the design of clinical trials i...
National Natural Science Foundation of China(grant no.82171267);National Key Research and Development Program of China(grant no.2021YFC2501102).
Background The risk factors of aetiology and poor outcome in angiographically negative subarachnoid haemorrhage(anSAH)were unclearly.Methods The authors performed a retrospective review of a prospectively maintained d...
Background In ischaemic stroke,minor deficits(National Institutes of Health Stroke Scale(NIHSS)≤5)at presentation are common but often progress,leaving patients with significant disability.We compared the efficacy an...
National Natural Science Foundation of China(81870905,U20A20358,82111530203);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M 5-029);The National Science and Technology Major Project(2017ZX09304018).
Background The benefit of intravenous alteplase in acute ischaemic stroke(AIS)is time-dependent.Tenecteplase is non-inferior to alteplase among patients with AIS.We aimed to delineate the association of the stroke ons...
National Key R&D Program of China(2022YFC2502400,2022YFC2502402,2022YFE0209600);National Natural Science Foundation of China(82101359,82111530203,U20A20358,31900487);Capital's Funds for Health Improvement and Research(2020-1-2041);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-5-029).
Background and aims Observational studies have implicated the involvement of gut microbiome in stroke development.Conversely,stroke may disrupt the gut microbiome balance,potentially causing systemic infections exacer...
National Natural Science Foundation of China(82001920,82071301,81820108012);Beijing Municipal Administration of Hospitals’Youth Programme(QML20210503).
Background Identification of futile recanalisation following endovascular therapy(EVT)in patients with acute ischaemic stroke is both crucial and challenging.Here,we present a novel risk stratification system based on...
Simcere Pharmaceutical Group,the Ministry of Science and Technology of the People’s Republic of China(2022YFC2504902,2022YFC2504904);National Natural Science Foundation of China(81801152,92046016);CAMS Innovation Fund for Medical Sciences(2019-I2M 5-029);Beijing Municipal Committee of Science and Technology(Z201100005620010,Z211100002921064).
Background Edaravone dexborneol is believed to be a novel cytoprotective drug,demonstrating a synergistic combination of antioxidative and anti-inflammatory properties in animal models.The Treatment of Acute Ischaemic...
Funding Brain Science and Brain Diseases Youth Innovation Program of Shanghai Zhou Liangfu Medical Development Foundation.
Cerebral amyloid angiopathy-related inflammation(CAA-ri)is a relatively rare and treatable subtype of CAA.We have herein reported a case of CAA-ri with repeated recurrent lobar haemorrhages within a short time as the ...
Organised stroke care has become a keystone in delivering efficient and effective treatment to patients with stroke with improved outcomes.Delivering timely acute reperfusion therapy to those with acute ischaemic stro...
Background We investigated outcomes in patients with intracerebral haemorrhage(ICH)according to prior anticoagulation treatment with Vitamin K antagonists(VKAs),direct oral anticoagulants(DOACs)or no anticoagulation.M...