《Liver Research》

作品数：276被引量：427H指数：9
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《Liver Research》
主办单位：中山大学附属第三医院
最新期次：2024年4期更多>>
发文主题：HEPATOCELLULAR_CARCINOMANAFLDLIVERHCCNASH更多>>
发文领域：医药卫生文化科学理学环境科学与工程更多>>
发文基金：国家自然科学基金广东省自然科学基金中国博士后科学基金上海市青年科技启明星计划更多>>
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《Liver Research》2024年第4期I0001-I0001,共1页
Chinese expert consensus on the clinical application of molecular diagnostics in hepatobiliary cancers(2024 edition)
《Liver Research》2024年第4期195-206,共12页Aizier Ainiwaer Jiamin Cheng Ren Lang Tao Peng Xinyu Bi Yinying Lu Chinese Research Hospital Association Society for Molecular Diagnosis Translational Medicine Branch,China Association of Gerontology and Geriatrics 
funded by the National Natural Science Foundation of China(No.82272956).
Hepatocellular carcinoma(HCC)and biliary tract cancer(BTC)are significant health challenges in China because of their high prevalence and mortality rates.Advances in molecular diagnostics have opened new avenues for p...
关键词：Hepatocellular carcinoma(HCC) Biliary tract cancer(BTC) Targeted therapy IMMUNOTHERAPY Molecular markers Expert consensus 
Chinese clinical practice guidelines for pediatric split liver transplantation
《Liver Research》2024年第4期207-217,共11页Binsheng Fu Xiao Feng Jianrong Liu Jie Ren Jin Wang Shuhong Yi Yang Yang Chinese Society of Organ Transplantation of Chinese Medical Association Surgery Group of Chinese Society of Surgery of Chinese Medical Association Transplantation Group of Chinese Society of Surgery of Chinese Medical Association South China Alliance of Split Liver Transplantation 
supported by grants from National Key Research and Development Program of China(2017YFA0104304);National Natural Science Foundation of China(81972286 and 82073171);Natural Science Foundation of Guangdong Province(2020A1515010574 and 2020A1515010302);Guangdong Science and Technology Program(2019B020236003 and 2020B1212060019).
Liver transplantation is an effective treatment for end-stage liver disease in children,and its clinical efficacy has been validated.Split liver transplantation(SLT)can effectively expand the donor liver pool for chil...
关键词：Split liver transplantation(SLT) Pediatric liver transplantation Liver transplantation DONOR RECIPIENT GUIDELINE 
Current status and new directions for hepatocellular carcinoma diagnosis
《Liver Research》2024年第4期218-236,共19页Jinqi Tu Bo Wang Xiaoming Wang Kugeng Huo Wanting Hu Rongli Zhang Jinyao Li Shijie Zhu Qionglin Liang Shuxin Han 
supported by the National Natural Science Foundation of China(No.32171167);Anhui Province Educational Natural Science Project(No.2023AH040254);Tianchi Talent Introduction Plan Innovative Leader of Xinjiang Ugyur Autonomous Region(No.51052401403).
Liver cancer ranks as the sixth most common cancer globally,with hepatocellular carcinoma(HCC)accounting for approximately 75%-85%of cases.Most patients present with moderately advanced disease,while those with advanc...
关键词：Hepatocellular carcinoma(HCC) Tumor marker Early detection Pathological origin and development 
Cigarette smoking and alcohol-related liver disease
《Liver Research》2024年第4期237-245,共9页Hui-Min Lin Jing-Rong Zhang Meng-Xue Li Hui Hou Hua Wang Yan Huang 
supported by grants from the National Natural Science Foundation of China(82370591);Hefei Natural Science Foundation of China(2023018);Scientific Research Project of Colleges and Universities of Anhui Province(Natural Science)(2023AH040078);Anhui Medical University Research Level Improvement Program(2023xkjT010).
China is a major consumer of alcohol and tobacco.Tobacco and alcohol use are closely linked,with up to 90%of alcoholics having a history of tobacco use,and heavy smokers also tending to be alcoholics.Alcohol-related l...
关键词：Cigarette smoking(CS) Alcohol-related liver disease(ALD) Electronic cigarettes(E-cigarettes) ALCOHOLISM Liver transplantation(LT) 
Application of mesenchymal stem cells in liver fibrosis and regeneration
《Liver Research》2024年第4期246-258,共13页Zhenyu Liu Junkai Ren Cheng Qiu Ying Wang Tong Zhang 
Liver transplantation remains the most effective treatment for end-stage liver disease(ESLD),but it is fraught with challenges such as immunosuppression,high risk and cost,and donor shortage.In recent years,stem cell ...
关键词：Liver transplantation End-stage liver disease(ESLD) Mesenchymal stem cells(MSCs) Liver regeneration Liver fibrosis 
Growth differentiation factor 7 alleviates the proliferation and metastasis of hepatocellular carcinoma
《Liver Research》2024年第4期259-268,共10页Jianyong Zhuo Huigang Li Peiru Zhang Chiyu He Wei Shen Xinyu Yang Zuyuan Lin Runzhou Zhuang Xuyong Wei Shusen Zheng Xiao Xu Di Lu 
the National Key Research and Development Programof China(No.2021YFA1100500);the Major Research Plan of the National Natural Science Foundation of China(No.92159202);the Key Research&Development Plan of Zhejiang Province(No.2021C03118);the National Natural Science Foundation of China(No.82303387 and No.82300742);the Natural Science Foundation of Zhejiang Province(No.LQ23H160048 and No.LQ22H160052);the Health Science&Technology Plan of Zhejiang Province(No.2022RC060);supported by the Construction Fund of Medical Key Disciplines of Hangzhou(No.OO20200093).
Background and aims:Inflammatory factors play significant roles in the development and occurrence of hepatocellular carcinoma(HCC).However,the tumor-protective functions of growth differentiation factors(GDFs)in HCC a...
关键词：Hepatocellular carcinoma(HCC) Growth differentiation factor 7(GDF7) JunB proto-oncogene(JUNB) Epithelial-mesenchymal transition(EMT) PROLIFERATION METASTASIS 
Kehuang capsule inhibits MAPK and AKT signaling pathways to mitigate CCl_(4)-induced acute liver injury
《Liver Research》2024年第4期269-281,共13页Qinyu Ni Jiacheng Lin Weifan Huang Liu Yang Ran Li Tianzhi Tu Guangfu He Yueqiu Gao Xuehua Sun Xiaoni Kong Xiaojun Zhu 
supported by the grant from the Shanghai Famous Old Chinese Medicine Academic Research Studio(No.SHGZS-202246).
Background and aims:Kehuang(KH)capsule is an herbal medical product approved for the treatment of liver diseases,including liver injury,in China.However,the mechanism is still unclear.This study aimed to elucidate the...
关键词：Kehuang capsule Acute liver injury(ALI) Carbon tetrachloride(CCl_(4)) Mitogen-activated protein kinase(MAPK) Protein kinase B(AKT) Network pharmacology 
Single-cell and machine learning approaches uncover intrinsic immune-evasion genes in the prognosis of hepatocellular carcinoma
《Liver Research》2024年第4期282-294,共13页Jiani Wang Xiaopeng Chen Donghao Wu Changchang Jia Qinghai Lian Yuhang Pan Jiumei Yang 
the Natural Science Foundation of Guangdong Province(No.2017A030310252,No.2022A1515012650);the Science and Technology Program of Guangzhou(No.2024A03J0919).
Background and aims:Hepatocellular carcinoma(HCC)is a tumor of high heterogeneity and complexity,which poses significant challenges to effective treatment and patient prognosis because of its immune evasion characteri...
关键词：Hepatocellular carcinoma(HCC) Intrinsic immune-evasion genes(IIEGs) The Cancer Genome Atlas(TCGA) Machine learning Single-cell analysis 
Long-term efficacy and safety of tenofovir alafenamide,tenofovir disoproxil fumarate,and entecavir in treating hepatitis B virus-related acute-on-chronic liver failure:A 144-week data analysis
《Liver Research》2024年第4期295-303,共9页Yeqiong Zhang Wenxiong Xu Zhexuan Deng Lu Wang Xingrong Zheng Xiang Zhu Xuejun Li Jianguo Li Xin Shu Jing Lai Liang Peng Chan Xie 
supported by grants from Key-Area Research and Development Program of Guangdong Province(No.2020B0101130015);Guangdong Medical Science and Technology Research Fund(No.A2021304);the Natural Science Foundation of China(No.82070611);Guangzhou Science and Technology Plan Projects(No.2023B03J1287);Guangzhou Science and Technology Program Key Projects(No.2023B01J1007);Sun Yat-Sen University Clinical Research 5010 Program(No.2020007);the Five-Year Plan of Third Affiliated Hospital of Sun Yat-sen University(No.2023W106);Clinical trial number:ClinicalTrials.gov ID:NCT03920618.
Background and aims:Antiviral therapy is essential for hepatitis B virus-related acute-on-chronic liver failure(HBV-ACLF).No data are available on the long-term prognosis or safety of tenofovir alafenamide(TAF),tenofo...
关键词：Tenofovir alafenamide(TAF) Tenofovir disoproxil fumarate(TDF) Entecavir(ETV) Hepatitis B virus(HBV) Acute-on-chronic liver failure(ACLF) 
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