《mLife》

作品数：148被引量：83H指数：4
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《mLife》
主办单位：Institute of Microbiology;Chinese Academy of Sciences
最新期次：2025年1期更多>>
发文主题：MICROBIOMEMICROBIALBACTERIALQUORUM_SENSINGCRISPR更多>>
发文领域：生物学医药卫生农业科学理学更多>>
发文基金：国家自然科学基金广东省自然科学基金广西壮族自治区自然科学基金中国博士后科学基金更多>>
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Synthetic evolution of Saccharomyces cerevisiae for biomanufacturing:Approaches and applications
《mLife》2025年第1期1-16,共16页Zhen Wang Xianni Qi Xinru Ren Yuping Lin Fanli Zeng Qinhong Wang 
supported by the National Key Research and Development Program of China(2021YFC2103300);National Natural Science Foundation of China(32161133019 and 32200067);Major Science and Technology Support Program Project in Hebei Province(24292902Z);Key Research and Development Program Projects of Hebei Province(22322905D);Industry University Research Cooperation Project of Shijiazhuang and University of Hebei province(241490062A);supported by Tianjin Industrial Synthetic Biology Innovation Team.
The yeast Saccharomyces cerevisiae is a well-studied unicellular eukaryote with a significant role in the biomanufacturing of natural products,biofuels,and bulk and value-added chemicals,as well as the principal model...
关键词：biomanufacturing metabolic performance Saccharomyces cerevisiae stress tolerance synthetic evolution 
Identification of novel components of the Ced and Upssystems in Saccharolobus islandicus REY15A
《mLife》2025年第1期17-28,共12页Pengju Wu Mengqi Zhang Yanlu Kou Shikuan Liang Jinfeng Ni Qihong Huang Yulong Shen 
supported by grants from the National Natural ScienceFoundation of China(32393973 and 32370033)to Y.S.;the National Key Research and Development Program ofChina(2020YFA0906800)to J.N.and Q.H.
In Sulfolobales cells,transcription of the Ups(UV-inducible pili of Sulfolobus)and Ced(Crenarchaeal system for exchange ofDNA)genes is highly induced by DNA damage,and the two systems play key roles in pili-mediated c...
关键词：CRENARCHAEA Ced chromosomal DNA exchange DNA damage response UPS 
Complexation of CcmB with CcmACD safeguards heme translocation for cytochrome c maturation
《mLife》2025年第1期29-44,共16页Yuanyou Xu Wei Wang Qianrou Zhang Sirui Han Jiahao Wang Shihua Wu Haichun Gao 
supported by the National Natural Science Foundation of China(31930003 and 41976087);the National Key R&D Program of China(2018YFA0901300).
Cytochrome c maturation(CCM),a posttranslational modification involving covalent attachment of heme to polypeptides(apocyt c),is essential for the activity and cellular function of cytochromes c.Here,we identify and s...
关键词：CcmABCD cytochrome c cytochrome c biosynthesis HEME heme translocation 
The endocytic pathway for absorption of exogenous RNAs in Verticillium dahliae
《mLife》2025年第1期45-54,共10页Chuanhui Liu Chen Cui Guanyin Zhou Feng Gao Jianhua Zhao Huishan Guo Yun Jin 
supported by the National Key R&D Programof China(2022YFD1400800);the National Natural ScienceFoundation of China grant(No.32270204);BiologicalBreeding of Early Maturing and Disease Resistant CottonVarieties(Project No.2023ZD04041).
RNAi technologies have been exploited to control viruses,pests,oomycetes,and fungal phytopathogens that cause disasters inhost plants,including many agronomically significant crops.Double-stranded RNA(dsRNA)or small in...
关键词：endocytic pathway pathogenic fungi RNA uptake small RNA 
Genome-wide siRNA library screening identifies human host factors that influence the replication of the highly pathogenic H5N1 influenza virus
《mLife》2025年第1期55-69,共15页Guangwen Wang Li Jiang Jinliang Wang Qibing Li Jie Zhang Fandi Kong Ya Yan Yuqin Wang Guohua Deng Jianzhong Shi Guobin Tian Xianying Zeng Liling Liu Zhigao Bu Hualan Chen Chengjun Li 
supported by the National Key Research and DevelopmentProgram of China(2021YFD1800203 and 2021YFD1800204);the National Natural Science Foundation of China(NSFC)(32192453,32272979,and 32172847);the China PostdoctoralScience Foundation(2019M660897);the Innovation Program ofChinese Academy of Agricultural Sciences(CAAS-CSLPDCP-202401);the Earmarked Fund for China Agriculture Re-search System(CARS-41-G12)。
The global dissemination of H5 avian influenza viruses represents a significant threat to both human and animal health.In thisstudy,we conducted a genome-wide siRNA library screening against the highly pathogenic H5N1 i...
关键词：genome-wide siRNA library screening GO analysis H5N1 influenza virus host cellular factor reactome pathwayanalysis 
Developing a microfluidic-based epicPCR reveals diversepotential hosts of the mcrA gene in marine cold seep
《mLife》2025年第1期70-82,共13页Wenli Shen Danrui Wang Jiangtao Li Yue Liu Yinzhao Wang Xingsheng Yang Xi Peng Bingliang Xie Lei Su Ziyan Wei Qing He Zhiyi Wang Kai Feng Wenbin Du Ye Deng 
supported by the NationalNatural Science Foundation of China(Nos.32001092,91851106,and 91951103).
Anaerobic methanotrophic(ANME)microbes play a crucial role in the bioprocess of anaerobic oxidation of methane(AOM).However,due to their unculturable status,their diversity is poorly understood.In this study,we establ...
关键词：anaerobic oxidation of methane cold seep epicPCR mcrA gene 
The role of PilU in the surface behaviors of Pseudomonas aeruginosa
《mLife》2025年第1期83-95,共13页Jingchao Zhang Yan Luo Yiwu Zong Shangping Lu Yi Shi Fan Jin Kun Zhao 
Supported by the National Natural ScienceFoundation of China(12374206)to K.Z.;National Key R&DProgram of China(2023YFC3402401)to K.Z.;National KeyR&D Program of China(2020YFA0906900)to F.J.;China,Postdoctoral Science Foundation(2023M740523)to J.Z.;Sichuan Provincial People's Hospital Research Fund ofthe Academy(2022B1013)to J.Z。
In Pseudomonas aeruginosa,the dynamic activity of type IV pilus(TFP)is essential for various bacterial behaviors.While PilU isconsidered a homolog of the TFP disassembling motor PilT,its specific roles remain unclear.U...
关键词：colony expansion pilU Pseudomonas aeruginosa twitching type IV pili 
A new type of ArsR transcriptional repressor controls transcription of the arsenic resistance operon of Arsenicibacter rosenii SM-1
《mLife》2025年第1期96-100,共5页Yujie Zhang Wenjun Wu Ke Huang Fang-Jie Zhao 
supported by the Natural Science Foundation of China(Grant Nos.42077210 and 41930758 to Ke Huang and Fang-jie Zhao,respectively).
Impact statement Arsenic is the most common toxic metalloid in the environment.Nearly all organisms have genes for arsenic detoxification.Arsenic detoxification genes are frequently organized in chromosomal or plasmid...
关键词：ars operon Ars responsive toxic metalloid evolution relationship ArsR transcriptional repressor arsenic resistance arsr repressor 
Avian tuberculosis identified as the potential diseasein an outbreak in wild migratory birds in China
《mLife》2025年第1期101-103,共3页Chunge Zhang Liang Wang Cheng Zhang Ning Zhang Heting Sun Dong Chu Siyuan Qin Zhenghai Ma Marina Gulyaeva Alexander Shestopalov Wenjun Liu George F.Gao Yuhai Bi 
approved by the Animal Ethics Committee ofthe Institute of Microbiology,Chinese Academy of Sciences(Approval Number:APIMCAS2018034 and APIMCAS2021112).
Impact statementThis study identifies avian tuberculosis as a potential cause of mass mortality in wild migratory birds in Inner Mongolia,China.Combining meta-transcriptomic sequencing and histopathological analysis,it...
关键词：disease associated pathogens Inner Mongolia avian tuberculosis surveillance wildlifediseases migratory birds meta transcriptomic sequencing histopathological analysisit wild migratory birds 
Reviewer Acknowledgments
《mLife》2025年第1期104-105,共2页
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