《Toxicology Advances》

作品数:29被引量:0H指数:0
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《Toxicology Advances》
主办单位:TMR Publishing Group
最新期次:2024年1期更多>>
发文主题:HEAVY_METALHEPATOTOXICITYIBIBIOACCUMULATIONBASED_ON更多>>
发文领域:医药卫生理学金属学及工艺生物学更多>>
发文基金:国家自然科学基金更多>>
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The causes of adverse reactions in traditional Chinese medicine
《Toxicology Advances》2024年第1期1-2,共2页Kai-Di Feng Yu-Jie Zeng Xiao-Hui Yang Xin-Ju Li 
With the increasingly widespread application of traditional Chinese medicine in clinical practice,the safety of traditional Chinese medicine has been given more attention.The occurrence of adverse drug reactions of tr...
关键词:MORTALITY CLINICAL bringing 
Protective effect of glycyrrhetinic acid against cantharidin-induced hepatotoxicity through reducing oxidative stress in mice
《Toxicology Advances》2024年第1期3-9,共7页Li-Juan Xiong Xiao-Hong Zhang Jia-Lu Zou Xuan Chen Wen-Zhong Feng Cong-Yun Meng Jian-Yong Zhang 
supported by the National Natural Science Foundation of China(Grants no.82060754,81803838);The ability establishment of sustainable use for valuable Chinese medicine resources(2060302);Science and technology project of Guizhou health and Health Committee(gzwkj2021-441);Science and Technology Department of Honghuagang District of Zunyi city of Guizhou province of China([2020]-17);Zunyi Medical University Postgraduate Research Fund(ZYK187).
Background:Cantharidin(CTD)is a commonly used natural product with anticancer properties;however,it has significant adverse effects,particularly hepatotoxicity.Glycyrrhetinic acid(GA),the active component of licorice,...
关键词:glycyrrhetinic acid CANTHARIDIN HEPATOTOXICITY oxidative stress Nrf2/Keap1 
Investigating the mechanism of action of Bu-Yang-Huan-Wu decoction in treating bleomycin-Induced pulmonary fibrosis through the epithelial-mesenchymal transition pathway
《Toxicology Advances》2024年第1期10-15,共6页Yu-Ming Wang Han-Zhou Li Huan-Tian Cui Yu-Hong Bian 
Background:To explore the effects and mechanisms of Bu-Yang-Huan-Wu Decoction on pulmonary fibrosis in mice.Methods:Forty-five C57BL/6J mice were randomly divided into three groups:Control,Model,and Bu-Yang-Huan-Wu De...
关键词:pulmonary fibrosis Bu-Yang-Huan-Wu decoction epithelial-mesenchymal transition BLEOMYCIN 
Magnesium cantharidate suppresses PP2A and ERK1/2 pathway to inhibit hepatocellular carcinoma cells
《Toxicology Advances》2024年第1期16-27,共12页Ze Wang Yu-Xi Huang Tian-Mu He Xiang-Yu Tan Xiao-Fei Li Yun Liu Rong Yan 
The research was financially supported by the National Natural Science Foundation of China(no.81760746);Science and Technology Department of Zunyi city of Guizhou province of China([2020]7);Guizhou Provincial Science&Technology Program(ZK[2022]615).
Background:Magnesium cantharidate(MC)is a protein phosphatase 2A(PP2A)inhibitor antitumor drug.However,its antitumor mechanism in hepatocellular carcinoma cell(HCC)remains unclear.Methods:PP2A lentiviral vector over e...
关键词:magnesium cantharidate ERK1/2 HCC PP2A 
Growth indices of seeds(maize and cowpea)grown in heavy metal contaminated soil treated with ginger extract
《Toxicology Advances》2023年第4期15-23,共9页Tatah Verwiyeh Silas Ezeonu Chukwuma Stephen Moses Adondua Abah Abu Sunday Michael Umaru John Isaac Roy Yohanna Emochone 
The consumption of maize and cowpea in Africa and developing countries is high,owing to the fact that they are readily available,coupled the with nutritional benefits they provide.Growth loss has been seen in crops cu...
关键词:CONTAMINANTS COWPEA ginger extract MAIZE heavy metals ANTIOXIDANT BIOREMEDIATION 
Antinephrotoxic and antihyperlipidaemic activities of Cucurbita maxima leaf supplemented diets in stz-induced diabetic rats
《Toxicology Advances》2023年第4期24-32,共9页Job Itanyi Onuche Arowora Kayode Adebisi Joseph Ikwebe Michael Sunday Abu 
Background:Cucurbita maxima plant materials are frequently used to manage a number of disorders,according to previous studies.Objective:The goal of the present report was to look into further possible effects of this ...
关键词:antinephrotoxic antihyperlipidaemic Cucurbita maxima supplementation STZ-induced DIABETES 
Occupational exposure to flour dust among bakery workers:prevalence,potential hazards and promising interventions
《Toxicology Advances》2023年第4期33-44,共12页Seyi-Samson Enitan Osareniro-Eguagie Osakue Esther-Ngozi Adejumo Temitope-Oyewole Olusanya Emmanuel-Olusegun Ileoma Comfort-Bosede Enitan Nwachi-Idume Ogbonna 
Occupational exposure to flour dust within bakery environments presents significant health hazards to bakery personnel.Flour dust,generated as a byproduct during baking,becomes airborne during the baking process,thus ...
关键词:flour dust bakery workers occupational exposure interventions health hazards 
Heavy metals and health risk analysis of arable farmlands in selected local government areas of Taraba State,Nigeria
《Toxicology Advances》2023年第4期1-7,共7页Bilyaminu Habibu Otitoju Olawale Francis Yakubu Ojochenemi Ejeh Moses Adondua Abah 
The soil environment is a reservoir of nutrients as well as pollutants,and because of this,most of our food items are ladened with lots of pollutants ranging from fertilizers,pesticides,herbicides to heavy metals(HM)....
关键词:heavy metals risk assessment cancer estimation toxicity BIOACCUMULATION CARCINOGENESIS 
Studies on Heavy Metals Levels in Hepatic Tissues of Cat Fishes(Clarias gariepinus)from River Ibi,Donga and Gindin-Dorowa in Taraba State Nigeria,in Relation to key Enzyme of heme Biosynthetic Pathway
《Toxicology Advances》2023年第4期8-14,共7页Ebenezer Morayo Ale Steve Osagie Asuelimen 
Fishes are excellent markers of the extent of pollution from heavy metals in aquatic environments given that they are found at various levels of the food chain.This study aimed to investigate the bioaccumulation of he...
关键词:heavy metals BIOACCUMULATION delta-aminolevulinic acid dehydratase Atomic Absorption Spectrophotometer Clarias gariepinus BIOACCUMULATION 
Redox and metabolic regulation of epigenetic modifications:an emerging toxic action mechanism
《Toxicology Advances》2023年第3期1-12,共12页Wan-Qian Guo Wu-Sheng Xiao Wei-Dong Hao 
This work is funded by National Natural Science Foundation of China(No.81773466)to W.H,and by Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease(No.DXWL2023-06)to W.X.
Epigenetic modifications modulate conformational structure of chromatin and consequently gene expression by enzyme-mediated chemical modifications of DNA and histones.The activities of epigenetic modifying enzymes dep...
关键词:epigenetic modifications redox state cellular metabolism 
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