CANTHARIDIN

作品数：13被引量：12H指数：2
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相关领域：医药卫生更多>>
相关作者：徐洁程卯生史清华王玉玲宋宏锐更多>>
相关机构：南京中医药大学沈阳药科大学华中农业大学西北农林科技大学更多>>
相关期刊：《Chinese Journal of Cancer Research》《Toxicology Advances》《Insect Science》《Chinese Herbal Medicines》更多>>
相关基金：国家自然科学基金广西壮族自治区自然科学基金更多>>
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The first chromosome-level genome assembly and transcriptome sequencing provide insights into cantharidin production of the blister beetles
《Integrative Zoology》2024年第5期929-940,共12页Chuang ZHOU Xiaofeng ZHENG Lei WANG Bisong YUE Chao DU Xu LIU 
supported by the National Natural Science Foundation of China(grant number:31960117);the Miaozi Project in Science and Technology Innovation Program of Sichuan Province(grant number:2022006).
Blister beetles(Coleoptera:Meloidae)produce a natural defensive toxin cantharidin(CTD),which has been used for various cancer treatments and other diseases.Currently,the lack of chromosome-level reference genomes in M...
关键词：blister beetle cantharidin biosynthesis chromosome-level genome cytochrome P450 differentially expressed gene Mylabris phalerata sexual dimorphism 
Comparative genomics provides insights into molecular adaptation to hypermetamorphosis and cantharidin metabolism in blister beetles(Coleoptera:Meloidae)
《Integrative Zoology》2024年第5期975-988,共14页Alessandra RICCIERI Lucrezia SPAGONI Ming LI Paolo FRANCHINI Marianna N.ROSSI Emiliano FRATINI Manuela CERVELLI Marco A.BOLOGNA Emiliano MANCINI 
funded by the project“NOCLOT—NuOvi farmaCi anticoaguLanti dalla biOdiversiTàdei meloidi”financed by Regione Lazio(grant nos.A0375-2020-36555 and CUP F85F21003680009);co-funded by MIUR-Italy Grants of Departments of Excellence—L.232/2016—art.1 cc.314–337 awarded to the Department of Science of Roma Tre University(2018–2022 and 2023–2027);supported by the project PON—Ricerca e Innovazione(MUR;Project Code:999900_PON_RTD_A7-G-15023_SCIENZE);support of NBFC to the University of Roma Tre—Department of Science and Sapienza University—Department of Biology and Biotechnologies,“Charles Darwin”,funded by the Italian Ministry of University and Research,PNRR,Missione 4 Componente 2,“Dalla ricerca all’impresa”,Investimento 1.4(Project CN00000033);supported also by Rome Technopole,PNRR grant M-4C-2Inv.1.5 CUP F832B22000040006 to MAB.
Blister beetles(Coleoptera:Meloidae)are currently subdivided into three subfamilies:Eleticinae(a basal group),Nemognathinae,and Meloinae.These are all characterized by the endogenous production of the defensive terpen...
关键词：genome evolution juvenile hormone larval development terpene production 
Multiorgan dysfunction syndrome due to high-dose cantharidin poisoning:A case report
《World Journal of Clinical Cases》2024年第12期2074-2078,共5页Wan-Ling Xu Wen-Jing Tang Wei-Ying Yang Li-Chao Sun Ze-Qun Zhang Wei Li Xiu-Xian Zang 
Supported by Jilin Province Science and Technology Agency Project,No.20210101350JC;Project of Jilin Provincial Finance Department,No.JLSWSRCZX2023-60;Beijing iGandan Foundation Fund for Artificial Liver,No.iGandanF-1082023-RGG025.
BACKGROUND This report delves into the diagnostic and therapeutic journey undertaken by a patient with high-dose cantharidin poisoning and multiorgan dysfunction syndrome(MODS).Particular emphasis is placed on the com...
关键词：CANTHARIDIN POISONING Multiorgan dysfunction syndrome Clinical treatment and management Case report 
Protective effect of glycyrrhetinic acid against cantharidin-induced hepatotoxicity through reducing oxidative stress in mice
《Toxicology Advances》2024年第1期3-9,共7页Li-Juan Xiong Xiao-Hong Zhang Jia-Lu Zou Xuan Chen Wen-Zhong Feng Cong-Yun Meng Jian-Yong Zhang 
supported by the National Natural Science Foundation of China(Grants no.82060754,81803838);The ability establishment of sustainable use for valuable Chinese medicine resources(2060302);Science and technology project of Guizhou health and Health Committee(gzwkj2021-441);Science and Technology Department of Honghuagang District of Zunyi city of Guizhou province of China([2020]-17);Zunyi Medical University Postgraduate Research Fund(ZYK187).
Background:Cantharidin(CTD)is a commonly used natural product with anticancer properties;however,it has significant adverse effects,particularly hepatotoxicity.Glycyrrhetinic acid(GA),the active component of licorice,...
关键词：glycyrrhetinic acid CANTHARIDIN HEPATOTOXICITY oxidative stress Nrf2/Keap1 
Analysis of the metabolic mechanism in Cantharidin-induced hepatotoxicity in LO2 cells using lipidomics analysis
《Asian Toxicology Research》2021年第2期14-24,共11页Jian-Yong Zhang Fang Liu Tian-Mu He Qi-Yi Wang Yan Zhang Xiao-Yan Yuan Xiao-Fei Li Can-Can Duan 
The National Natural Science Foundation of China(Grants no.81760746 and 81803838);Education Department of Guizhou Province of China(GNYL[2017]006);Provincial Department of Education youth talent support program(qiankehe KY[2017]078);Guizhou Provincial Science&Technology“125-Plan”Major Project([2015]039).
Background:Cantharidin is a major active compound from Banmao(Mylabris).Cantharidin has obvious anticancer activity.However,its clinical application is limited due to serious hepatotoxicity.Methods:To evaluate the tox...
关键词：Hepatoxicity CANTHARIDIN LC-MS LIPIDOMICS 
Lipase-catalyzed Synthesis of 6-O-acyl-D-galactose Ester for Surface Modification of Cantharidin Liposomal Nanoparticles
《Medicinal Plant》2019年第2期25-27,共3页Xin TANG Jiaxun LIN Wei ZHANG Wei WU 
Supported by the National Natural Science Foundation of China(81560653);Natural Science Foundation of Guangxi(2016GXNSFAA380081)
[Objectives] To prepare and characterize a novel liver targeted drug carrier. [Methods] 6-O-acyl-D-galactose esters were enzymatically synthesized as a targeting molecule and incorporated into liposomes to prepare lip...
关键词：Liver targeted drug carrier Charatcterization ENZYMATIC synthesis 
Characterized cantharidin distribution and related gene expression patterns in tissues of blister beetles, Epicauta chinensis
《Insect Science》2019年第2期240-250,共11页Ming Jiang Shu-Min Lu Zi-Yi Qi Ya-Lin Zhang 
the Special Fund for the Public Interest (Agriculture)(Grant No. 200903052);the "113115" Sci-Tech Innovation Project of Shaanxi Province (No. 2007ZDKG-14 and No. 2009ZDKG-06), the National Natural Science Foundation of China (No. 31101442);the Fundamental Research Funds for the Central Universities (No. 2452015113 and No. 2452013QN044).
Cantharidin (CTD), a terpenoid defensive toxin mainly produced by blister beetles, is widely known by its toxicity to both cancer cells and pests. However, little information is known about its biosynthesis in blister...
关键词：biosynthesis CTD Epicauta CHINENSIS tissue TRANSCRIPT level 
Cantharidin suppresses HCT116 colorectal carcinoma cell proliferation and migration by changing the cytoskeleton structure
《Journal of Traditional Chinese Medical Sciences》2018年第3期302-309,共8页Xin Zhang Tongtong Sui Qixiang Ma Haozhen Shao Xiaowei Hu Honghao Sheng Zhitao Ma Guangbin Luo 
Background:Cantharidin (CTD),a natural toxin produced from Chinese blister beetles,has extensive anti-tumor activity.The present study investigated the effect of CTD on a human colon cancer cell line to elucidate pote...
关键词：CANTHARIDIN ACTIN CYTOSKELETON Cell adhesion Proliferation MIGRATION 
Physicochemical Properties and Gastric Mucosa Irritation of Cantharidin-hydroxypropyl-β-cyclodextrin Inclusion Complex被引量：5
《Chinese Herbal Medicines》2012年第3期224-229,共6页Lin-na AN Yun-jie DANG Chun-hui HU Chun-yan ZHU 
National S&T Major Special Project on Major New Drug Innovation (2009ZX09301-003&2008ZX09103-390)
Objective To increase the solubility and relieve the mucous irritation of cantharidin (CA) by preparing cantharidin-hydroxypropyl-β-cyclodextrin (CA/HP-β-CD) inclusion complex. Methods The inclusion complex was prep...
关键词：CANTHARIDIN DISSOLUTION HYDROXYPROPYL-Β-CYCLODEXTRIN mucous irritation SOLUBILITY 
Inhibitory Effect of Cantharidin on Proliferation of A549 Cells被引量：1
《Chinese Journal of Cancer Research》2007年第4期283-286,共4页王晓华 尹元琴 隋承光 孟凡东 马萍 姜又红 
Objective： To study the inhibition of Cantharidin against the proliferation of human lung cancer A549 cells and its mechanism. Methods： MTT assay was employed to determine the inhibition of Cantharidin against proli...
关键词：Cantharidin（CTD） INHIBITION Human lung cancer cells A549 
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