目的:组蛋白甲基转移酶——variegation,zeste增强子和trithorax域3的核受体抑制剂(nuclear receptor suppressor of variegation,enhancer of zeste,and trithorax domain-containing 3,NSD3)在肾癌中的生物学作用还不清楚。本研究旨...
the National Natural Science Foundation of China(32025003);by the National Key Research and Development Program of China(2016YFA0500801)from the Chinese Ministry of Science and Technology。
Although the Trithorax histone methyltransferases ATX1-5 are known to regulate development and stress responses by catalyzing histone H3 K4 methylation in Arabidopsis thaliana,it is unknown whether and how these histo...
funded by National Science Foundation grant MCB1916431 to D.W.
Dear Editor,In multicellular eukaryotes,Polycomb repression heritably si-lences gene expression programs not needed or detrimental for a given developmental stage or tissue(Schuettengruber et al.,2017).During cell fat...
This work was supported by Beijing Natural Science Foundation (grant 5182028 to L.P.), the Agricultural Science and Technology Innovation Program, CAAS, China (to L.P.), the National Science Foundation, USA (NSF grant lOS 0956409 to Z.R.So), and the National Science Council, Taiwan, China (grant NSC 98-2311-B-001-001-MY3 to L.O.C.).
Polycomb group (PcG) and trithorax group (trxG) proteins have been shown to act antagonistically to epigenetically regulate gene expression in eukaryotes. The trxG proteins counteract PcG-mediated floral repressio...
The Polycystic Ovary Syndrome (PCOS) is the most common androgenic disorder in women during reproductive life. PCOS may also be accompanied by metabolic syndrome and recent studies point to leptin as playing a role in...
Drosophila RYBP (dRYBP; Ringl and Y_Y1 Binding Protein) is a Polycomb and trithorax interacting protein, whose homologous RYBP/DEDAF mammalian counterparts exhibit tumor cell-specific killing activity. Here we show ...