ORIGEN

作品数：68被引量：294H指数：10
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相关作者：张春明余纲林王侃田文喜秋穗正更多>>
相关机构：清华大学中华人民共和国环境保护部华北电力大学西安交通大学更多>>
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相关基金：国家自然科学基金国家科技重大专项教育部留学回国人员科研启动基金北京市自然科学基金更多>>
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Wnt/GSK-3βmediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon
《Cancer Communications》2025年第1期9-14,共6页Sheema Almozyan Roya Babaei-Jadidi Abrar Aljohani Sepideh Youssefi William Dalleywater Prerna Kadam Bradley Spencer-Dene Emad Rakha Mohammad Ilyas Abdolrahman Shams Nateri 
supported by the Medical Research Council(MRC)(grant number G0700763);by the University of Nottingham,Nottingham,UK.
The intestinal epithelium undergoes rapid renewal,with the entire epithelial layer replaced within five days.Intestinal stem cells(ISCs),located in the intestinal crypts,generate all differentiated cell types necessar...
关键词：TUMORIGENESIS COLON HOMEOSTASIS 
PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop被引量：2
《Cancer Communications》2022年第10期987-1007,共21页Xinyuan Zhao Dalong Shu Wenjuan Sun Shanshan Si Wei Ran Bing Guo Li Cui 
National Natural Science Foundation of China,Grant/Award Number:81901006;Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2020A1515110051;Scientific Research Talent Cultivation Project of Stomatological Hospital,Southern Medical University,Grant/Award Number:RC202005;Science Research Cultivation Program of Stomatological Hospital,Southern Medical University,Grant/Award Number:PY2020002。
Background:Head and neck squamous cell carcinoma(HNSCC)is one of the most frequent malignancies worldwide and is characterized by unfavorable prognosis,high lymph node metastasis and early recurrence.However,the molec...
关键词：C-MYC cancer stemness FBXW7 HNSCC PLEK2 positive feedback loop tumorigenesis ubiquitination-mediated degradation 
The role of the HIF-1α/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer被引量：34
《Cancer Communications》2021年第7期560-575,共16页Jing-Zi Wang Wei Zhu Jie Han Xiao Yang Rui Zhou Hong-Cheng Lu Hao Yu Wen-Bo Yuan Peng-Chao Li Jun Tao Qiang Lu Ji-Fu Wei Haiwei Yang 
supported by grants from the National Natural Science Foundation of China(81602235,81772711);the“333”project of Jiangsu Province(LGY2018055,LGY2016002);Key Provincial Talents Program of Jiangsu Province(ZDRCA2016006);the Priority Academic Program Development of Jiangsu Higher Education Institutions(JX10231801);the Provincial Initiative Program for Excellency Disciplines of Jiangsu Province(BE2016791).
Background:As a rate-limiting enzyme of glycolysis,pyruvate kinase muscle isozyme M2(PKM2)participates in tumor metabolism and growth.The regulatory network of PKM2 in cancer is complex and has not been fully studied ...
关键词：PKM2 ALYREF GLYCOLYSIS 5-methylcytidine modification bladder cancer HIF-1Α 
Insulin gene enhancer protein 1 mediates glycolysis and tumorigenesis of gastric cancer through regulating glucose transporter 4被引量：8
《Cancer Communications》2021年第3期258-272,共15页Ting Guo Yan-Hua Bai Xiao-Jing Cheng Hai-Bo Han Hong Du Ying Hu Shu-Qin Jia Xiao-Fang Xing Jia-Fu Ji 
Natural Science Foundation of Beijing,Grant/Award Number:7132051;National Natural Science Foundation of China,Grant/Award Numbers:81301874,81972758,81872502,81802471;Interdisciplinary Medicine Seed Fund of Peking University,Grant/Award Number:BMU2018MX018;Beijing Municipal Administration of Hospitals’Youth Program,Grant/Award Number:QML20181102;National High Technology Research and Development Program of China,Grant/Award Number:2014AA020603;Science Foundation of Peking University Cancer Hospital,Grant/Award Numbers:2017-23,2020-6。
Background:Insulin gene enhancer protein 1,(ISL1),a LIM-homeodomain transcription factor,is involved in multiple tumors and is associated with insulin secretion and metabolic phenotypes.However,the role of ISL1 in sti...
关键词：gastric cancer glucose transporter 4 GLYCOLYSIS insulin gene enhancer protein 1 TUMORIGENESIS 
DDIT4 promotes gastric cancer proliferation and tumorigenesis through the p53 and MAPK pathways被引量：17
《Cancer Communications》2018年第1期474-487,共14页Feng Du Lina Sun Yi Chu Tingyu Li Chao Lei Xin Wang Mingzuo Jiang Yali Min Yuanyuan Lu Xiaodi Zhao Yongzhan Nie Daiming Fan 
supported by the National Natural Science Foundation of China(Nos.81430072,81421003,81602641,81572929).
Background:Gastric cancer(GC)is one of the most common malignancies worldwide,particularly in China.DNA damage-inducible transcript 4(DDIT4)is a mammalian target of rapamycin inhibitor and is induced by various cellul...
关键词：DNA damage-inducible transcript 4 Gastric cancer PROLIFERATION Mitogen-activated protein kinase P53 
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