supported by the National Key Research and Development Program of China(2019YFA0508502 to XL);National Natural Science Foundation of China(31930039,31821003,91942303 to XL);the General Financial Grant from the China Postdoctoral Science Foundation(2020M670301 to YX);annual funding from Tsinghua University-Peking University Jointed Center for Life Sciences.
Invasive fungal infections are life-threatening,and neutrophils are vital cells of the innate immune system that defend against them.The role of LTA4H-LTB_(4)-BLT1 axis in regulation of neutrophil responses to fungal ...
Scientific research project of cadre health care in Sichuan province(No.2018-605)。
Objective:To investigate the effect of shufengzhitong decoction combined with four cervical needles on cervical spondylotic radiculopathy(CSR)and leukotriene and inflammatory factors.Methods:110 patients with CSR were...
supported by National Natural Science Foundation of China(81402482,91313303)
OBJECTIVE Leukotriene B4(LTB4)biosynthesis and subsequently neutrophilic inflammation may provide a potential strategy for the treatment of acute lung injury(ALI)or idiopathic pulmonary fibrosis(IPF).To provide a pote...
The pentacyclic triterpenic acids isolated from the oleo gum resin of various Boswellia species are collectively called as Boswellic acids(BA).The oleo gum resin obtained from Indian variety i.e.Boswellia serrata(Fami...
financially supported by the National Natural Science Foundation of China(No.21272071);the Fundamental Research Funds for the Central Universities;support from Shanghai Foundation of Science and Technology(No.15431902100)
A series of novel 1,2,3-benzotriazin-4-one derivatives were designed,synthesized and their inhibitory activities against leulcotriene A4 hydrolase aminopeptidase in vitro were evaluated.Many compounds showed moderate ...
Objective:To study the effect of glucocorticoid inhalation combined with oral montelukast on airway function and serum inflammatory cytokines in patients with bronchial asthma. Methods: 138 patients diagnosed with bro...
Granulopoiesis in murine bone-marrow is regulated by both intrinsic and extrinsic factors(including hormones, drugs, inflammatory mediators and cytokines). Eosinophils, a minor subpopulation of circulating leukocytes,...
Since the mechanisms of the developmental processes of tumors remain unclear, early detection and early treatment of the tumors is necessary to save patients with malignant tumors. Therapies currently available to pat...
Some drugs that regulate estrogen are currently used as therapy for endometriosis. However, these medical treatments have significant side effects and patients who hope to become pregnant cannot overcome infertility. ...