LEUKOTRIENE

作品数:31被引量:81H指数:5
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相关领域:医药卫生更多>>
相关作者:罗妍妍卢红艳许云仙金蕊胡毓华更多>>
相关机构:江苏省人民医院江苏大学附属医院复旦大学上海医学院复旦大学更多>>
相关期刊:《Acta Biochimica et Biophysica Sinica》《Cellular & Molecular Immunology》《中华肾脏病杂志》《天津医药》更多>>
相关基金:国家自然科学基金国家科技支撑计划国家重点基础研究发展计划更多>>
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Activation of leukotriene B_(4)receptor 1 is a prerequisite for complement receptor 3-mediated antifungal responses of neutrophils
《Cellular & Molecular Immunology》2024年第3期245-259,共15页Yan Xin Sihan Xiong Linghong Zhou Xin Lin 
supported by the National Key Research and Development Program of China(2019YFA0508502 to XL);National Natural Science Foundation of China(31930039,31821003,91942303 to XL);the General Financial Grant from the China Postdoctoral Science Foundation(2020M670301 to YX);annual funding from Tsinghua University-Peking University Jointed Center for Life Sciences.
Invasive fungal infections are life-threatening,and neutrophils are vital cells of the innate immune system that defend against them.The role of LTA4H-LTB_(4)-BLT1 axis in regulation of neutrophil responses to fungal ...
关键词:LTA4H BLT1 PHAGOCYTOSIS Complement receptor 3 FUNGI 
The effect of Shufengzhitong decoction combined with four cervical needles on cervical spondylotic radiculopathy and leukotriene and inflammatory factors
《Journal of Hainan Medical University》2021年第4期34-39,共6页Biao Wang Liu-Gang Tang Xiao-Hui Wu Yuan-Dong Cheng Hao-Chen Tang 
Scientific research project of cadre health care in Sichuan province(No.2018-605)。
Objective:To investigate the effect of shufengzhitong decoction combined with four cervical needles on cervical spondylotic radiculopathy(CSR)and leukotriene and inflammatory factors.Methods:110 patients with CSR were...
关键词:Radicular Cervical spondylosis Shufeng Zhitong decoction Cervical four needle LEUKOTRIENE Inflammatory factor 
Drug repurposing of histone deacetylase inhibitors that alleviate neutrophilic inflammation in acute lung injury and idiopathic pulmonary fibrosis via inhibiting leukotriene a4 hydrolase and blocking LTB4 biosynthesis被引量:4
《中国药理学与毒理学杂志》2017年第10期972-972,共1页Wei-qiang LU Jing-yuan WANG Xue YAO Ping OUYANG Ning-ning DONG Dang WU Jin HUANG 
supported by National Natural Science Foundation of China(81402482,91313303)
OBJECTIVE Leukotriene B4(LTB4)biosynthesis and subsequently neutrophilic inflammation may provide a potential strategy for the treatment of acute lung injury(ALI)or idiopathic pulmonary fibrosis(IPF).To provide a pote...
关键词:acute lung injury idiopathic pulmonary fibrosis histone deacetylase inhibitors alleviate neutrophilic inflammation leukotriene A4 hydrolase leukotriene B4 
Phytochemistry and potential therapeutic actions of Boswellic acids:A mini-review被引量:3
《Asian Pacific Journal of Tropical Biomedicine》2017年第6期513-523,共11页Farah Iram Shah Alam Khan Asif Husain 
The pentacyclic triterpenic acids isolated from the oleo gum resin of various Boswellia species are collectively called as Boswellic acids(BA).The oleo gum resin obtained from Indian variety i.e.Boswellia serrata(Fami...
关键词:Boswellia serrata Boswellic acids INFLAMMATION Leukotriene synthesis 5-LIPOXYGENASE 
Synthesis and biological evaluation of novel 1,2,3-benzotriazin-4-one derivatives as leukotriene A4 hydrolase aminopeptidase inhibitors
《Chinese Chemical Letters》2017年第5期1044-1048,共5页Fan Zhang Dang Wu Gao-Lei Wang Shuang Hou Ping Ou-Yang Jin Huang Xiao-Yong Xu 
financially supported by the National Natural Science Foundation of China(No.21272071);the Fundamental Research Funds for the Central Universities;support from Shanghai Foundation of Science and Technology(No.15431902100)
A series of novel 1,2,3-benzotriazin-4-one derivatives were designed,synthesized and their inhibitory activities against leulcotriene A4 hydrolase aminopeptidase in vitro were evaluated.Many compounds showed moderate ...
关键词:1 2 3-Benzotriazin-4-one Leukotriene A4 hydrolase Aminopeptidase activity In vitro Aminopeptidase inhibitors 
Effect of glucocorticoid inhalation combined with oral montelukast on airway function and serum inflammatory cytokines in patients with bronchial asthma被引量:2
《Journal of Hainan Medical University》2017年第3期54-57,共4页Bang-Su Lin 
Objective:To study the effect of glucocorticoid inhalation combined with oral montelukast on airway function and serum inflammatory cytokines in patients with bronchial asthma. Methods: 138 patients diagnosed with bro...
关键词:BRONCHIAL asthma MONTELUKAST LEUKOTRIENE Airway function Inflammatory cytokines 
Odd couple: The unexpected partnership of glucocorticoid hormones and cysteinyl-leukotrienes in the extrinsic regulation of murine bone-marrow eosinopoiesis被引量:2
《World Journal of Experimental Medicine》2017年第1期11-24,共14页Pedro Xavier-Elsas Daniela Masid-de-Brito Bruno Marques Vieira Maria Ignez C Gaspar-Elsas 
Granulopoiesis in murine bone-marrow is regulated by both intrinsic and extrinsic factors(including hormones, drugs, inflammatory mediators and cytokines). Eosinophils, a minor subpopulation of circulating leukocytes,...
关键词:Bone MARROW LEUKOTRIENE EOSINOPHIL Stress GLUCOCORTICOID 
尿半胱氨酸白三烯E4诊断支气管肺发育不良的临床评价被引量:9
《中华儿科杂志》2016年第9期703-707,共5页金蕊 卢红艳 罗妍妍 许云仙 胡毓华 陈筱青 
国家自然科学基金(81300521,81300023,81370746)
目的 探讨新生儿尿液半胱氨酸白三烯E4(CysLTE4)水平与支气管肺发育不良(BPD)的关系.方法 收集2014年11月至2015年10月南京医科大学第一附属医院收治的新生儿158例,出院后根据出院诊断将其分为3组:无肺部疾病的足月儿61例(足月组...
关键词:白三烯E4 支气管肺发育不良 婴儿 新生 LEUKOTRIENE E4 
Mast Cell Infiltration and Leukotriene Receptor Expression in Various Tumors: Possible Clinical Application of Common Pathological Findings Concerned with Tumor Development
《Journal of Cancer Therapy》2015年第7期606-612,共7页Masao Sugamata Tomomi Ihara Miho Sugamata 
Since the mechanisms of the developmental processes of tumors remain unclear, early detection and early treatment of the tumors is necessary to save patients with malignant tumors. Therapies currently available to pat...
关键词:MAST Cell LEUKOTRIENE RECEPTOR Anti-Leikotriene Therapy Apoptosis 
A New Therapy for Human Endometriosis: The Therapeutic Value of Leukotriene Receptor Antagonist for Endometriosis被引量:1
《Open Journal of Obstetrics and Gynecology》2015年第6期313-318,共6页Masao Sugamata Tomomi Ihara Ichiro Uchiide 
Some drugs that regulate estrogen are currently used as therapy for endometriosis. However, these medical treatments have significant side effects and patients who hope to become pregnant cannot overcome infertility. ...
关键词:ENDOMETRIOSIS LEUKOTRIENE Receptor Apoptosis r-AFS SCORE INFERTILITY 
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