TRIPHOSPHATE

作品数：61被引量：153H指数：5
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Enhanced population of excited single state strategy:Irradiation and ultrasound dual-response and host tumor-driven nanosensitizers construction in triple synergistic therapy
《Nano Research》2024年第6期5501-5511,共11页Yaning Li Mengyan Tian Tianyue Yang Jiayu Cao Hongli Chen Jun Guo Pai Liu Yi Liu 
the financial support from the National Natural Science Foundation of China(Nos.U23A2089,22205159,and 22103055);Natural Science Foundation of Tianjin(No.21JCQNJC01450);Science and Technology Plans of Tianjin(Nos.22ZYJDSS00070 and 21ZYJDJC00050).
Phototheranostics is an emerging field in synergistic antitumor therapy in which irradiation and sensitizers are combined to produce reactive oxygen species(ROS),bio-images,and high temperatures.All of these are arriv...
关键词：triphosphate(ATP)-activated nano-sensitizers photo-sonodynamic therapy aggregation-induced emission enhanced excited state population 
Commentary Potential Enhancement by 3-Deazauridine of the Antiviral Activity of Molnupiravir in Patients with COVID-19
《Advances in Infectious Diseases》2023年第2期210-215,共6页Richard L. Momparler 
Background: Molnupiravir, N4-hydroxycytidine-5’-isopropyl ester, is an oral prodrug of N4-deoxycytidine (NHC), a nucleoside analog, which has in vitro activity against SARS-CoV-2. NHC is phosphorylated in cells to NH...
关键词：Molnupiravir N4-Hydroxycytidine-5’-Triphosphate 3-Deazauridine COVID-16 Antiviral Therapy 
Liposomal remdesivir inhalation solution for targeted lung delivery as a novel therapeutic approach for COVID-19
《Asian Journal of Pharmaceutical Sciences》2021年第6期772-783,共12页Jingjing Li Kai Zhang Di Wua Lianjie Ren Xinyu Chu Chao Qin Xiaopeng Han Taijun Hang Yungen Xu Lei Yang Lifang Yina 
supported by National Natural Science Foundation(81871477,81603051,and 81673377);Natural Science Foundation of Jiangsu Province(BK20160760 and BK20170748);The Anti-COVID-19 Emergency Research Project of China Pharmaceutical University(2632020ZX007);The Creation of Major New Drugs National Major Projects(2017ZX09101001-004);Fundamental Research Funds for the Central Universities(2016ZPY015,2632017PY18).
Strong infectivity enables coronavirus disease 2019(COVID-19)to rage throughout the world.Moreover,the lack of drugs with definite therapeutic effects further aggravates the spread of the pandemic.Remdesivir is one of...
关键词：COVID-19 Remdesivir Pulmonary delivery Liposomal aerosol Nucleotide triphosphate 
Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice
《Acta Pharmacologica Sinica》2021年第7期1195-1200,共6页Wen-juan Hu Lu Chang Ying Yang Xin Wang Yuan-chao Xie Jing-shan Shen Bo Tan Jia Liu 
This study was supported by the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2016263).
Remdesivir (RDV) exerts anti-severe acute respiratory coronavirus 2 activity following metabolic activation in the target tissues. However, the pharmacokinetics and tissue distributions of the parent drug and its acti...
关键词：remdesivir PHARMACOKINETICS tissue distribution nucleotide monophosphate nucleotide triphosphate NUCLEOSIDE 
Optogenetic Control of Phosphatidylinositol (3,4,5)-Triphosphate Production by Light-Sensitive Cryptochrome Proteins on the Plasma Membrane被引量：1
《Chinese Journal of Chemistry》2021年第5期1240-1246,共7页Lingzhi Yang Takeaki Ozawa Haifeng Dong Xueji Zhang 
the National Natural Science Foundation of Guangdong Province project(No.2018A030310579);the Medical Research Foundation of Guangdong Province project(No.A2019024);CREST(No.JPMJCR1752 to T.O.)from Japan Science and Technology(JST),and the Japan Society for the Promotion of Science(JSPS)KAKENHI(Grants-in-Aid for Scientific Research(A)19H00900 and Innovative Areas JP 18K19092 to T.0.).
Phosphatidylinositol(3,4,5)-triphosphate(PIP3),acting as a fundamental second messenger,is emerging as a promising biomarker for disease diagnosis and prognosis.However,the real time analysis of phosphoinositide in li...
关键词：Protein-protein interactions Protein engineering Fluorescent probes Optogenetic control Phosphatidylinosito (3 4 5)-triphosphate 
Guanosine-5'-triphosphate cyclohydrolase 1 regulated long noncoding RNAs are potential targets for microglial activation in neuropathic pain被引量：4
《Neural Regeneration Research》2021年第3期596-600,共5页Yan-Hu Liang Guo-Wu Chen Xue-Song Li Shu Jia Chun-Yang Meng 
supported by the National Natural Science Foundation of China,Nos.81572205 and 81974345(both to CYM)。
Several studies have confirmed that microglia are involved in neuropathic pain.Inhibition of guanosine-5′-triphosphate cyclohydrolase 1(GTPCH1)can reduce the inflammation of microglia.However,the precise mechanism by...
关键词：cells factors INFLAMMATION MICROGLIA PAIN pathway protein RNA 
Coarse-Grained Free-Energy Simulations of Conformational State Transitions in an Adenosine 5′-Triphosphate-binding Cassette Exporter被引量：1
《Chinese Journal of Chemical Physics》2020年第6期712-716,I0002,共6页Yun Huang Hao-chen Xu Jie-lou Liao 
supported by the National Natu-ral Science Foundation of China(No.21073170 and No.21273209).
ATP-binding cassette exporters transport many substrates out of cellular membranes via alternating between inward-facing and outward-facing conformations. Despite extensive research efforts over the past decades, unde...
关键词：ATP-binding cassette exporter Conformational state transition Coarse-grained molecular dynamics Potential of mean force 
The effect of vitamin D on sperm motility and the underlying mechanism被引量：13
《Asian Journal of Andrology》2019年第4期400-407,共8页Kadiliya Jueraitetibaike Zheng Ding Dan-Dan Wang Long-Ping Peng Jun Jing Li Chen Xie Ge Xu-Hua Qiu Bing Yao 
the Research Funds for Jiangsu Province Key Research and Development Plan (Grant No. BE2016750);Research Funds for Military Family Planning (Grant No. 16JS012);Six Talent Peaks Project in Jiangsu Province (Grant No. 2017-WSW-033);Chinese Medical Association Special Fund for Clinical Medical Research (Grant No. 17020350704);Foundation for Key Medical Talents in Jiangsu Province (Grant No. ZDRCA2016096);Natural Science Foundation of Jiangsu Province (Grant No. BK20170620);China Postdoctoral Science Foundation (Grant No. 2017M613434);National Natural Science Foundation of China (Grant No. 81701431 and 81701440).
Vitamin D deficiency is a common health issue around the world. We therefore evaluated the associations of semen quality with both serum and seminal plasma vitamin D levels and studied the mechanisms underlying these ...
关键词：ade no SINE TRIPHOSPHATE semi nal plasma SPERM MOTILITY VITAMIN D 
β-Cyclodextrin polymer based fluorescence enhancement method for sensitive adenosine triphosphate detection
《Chinese Chemical Letters》2019年第6期1249-1252,共4页Chunxia Song Yuxin Xiao Kunpeng Li Xiaoyu Zhang Ying Lu 
financially supported by the National Natural Science Foundation of China (Nos. 21305002 and 21705002);the Scientific Research Foundation of Anhui Agricultural University (No. yj2017-19)
Adenosine triphosphate plays a crucial role in regulation of many biological pathways and has been used as an indicator for many diseases.In this pape r,based on the fact that β-cyclodextrin polymer(polyβ-CD)could s...
关键词：Β-CYCLODEXTRIN polymer SUPRAMOLECULAR assembly FLUORESCENCE Enhancement ADENOSINE TRIPHOSPHATE 
ATP结合盒家族G蛋白亚家族2单核苷酸多态性与高尿酸血症的关系被引量：2
《中华内科杂志》2017年第11期833-838,共6页张冰清 方卫纲 张昀 刘淑芬 曾学军 
卫生部行业科研专项项目（201302008）
目的 研究在不同年龄、性别中ATP结合盒家族G蛋白亚家族2（ABCG2）单核苷酸多态性rs2231142（C〉A）与高尿酸血症的相关性.方法 选北京协和医院职工体检人群为研究对象,男性血尿酸〉416.4μmol/L、女性血尿酸〉359.6μmol/L者纳入高尿...
关键词：高尿酸血症 ATP结合盒家族G蛋白亚家族2 多态性 单核苷酸 雌激素类 Adenosine TRIPHOSPHATE binding cassette subfamily G member-2 
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