MATRINE

作品数：83被引量：532H指数：14
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相关领域：医药卫生更多>>
相关作者：张俊平阮丽萍周俭平王玲罗大力更多>>
相关机构：第二军医大学哈尔滨医科大学中国人民解放军南京军区南京总医院更多>>
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相关基金：国家自然科学基金广东省自然科学基金福建省自然科学基金更多>>
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  • 期刊=Chinese Chemical Lettersx
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An innovative rhein-matrine cocrystal: Synthesis, characterization,formation mechanism and pharmacokinetic study被引量：1
《Chinese Chemical Letters》2023年第2期546-549,共4页Hongjuan Wang Dezhi Yang Wen Zhang Junke Song Ningbo Gong Mingchao Yu Shiying Yang Baoxi Zhang Qiwen Liu Guanhua Du Yang Lu 
supported by Drug Innovation Major Project (Nos. 2018ZX09711001–001–015, 2018ZX09711001–003– 022);CAMS Innovation Fund for Medical Sciences (No. 2016I2M-3–007)。
Rhein(Rhe), an anthraquinone derivative, exhibits excellent anti-inflammatory effects and other pharmacological activities, but its clinical application remains limited due to poor solubility. The present work aims at...
关键词：RHEIN MATRINE COCRYSTAL Poor solubility Molecular surface electrostatic potential 
Alopecuroidines A-C, three matrine-derived alkaloids from the seeds of Sophora alopecuroides被引量：1
《Chinese Chemical Letters》2021年第12期4058-4062,共5页Xiang Yuan Zhenyuan Li Ziming Feng Jianshuang Jiang Yanan Yang Peicheng Zhang 
supported by grants from CAMS Innovation Fund for Medical Sciences (No. 2016-I2M-1-010, China);the Drug Innovation Major Project (No. 2018ZX09711001-008, China)。
Three matrine-derived alkaloids, alopecuroidine A(1), alopecuroidine B(2 a) and alopecuroidine C(2 b)were isolated from the seeds of Sophora alopecuroides. Their structures were elucidated by extensive spectroscopic a...
关键词：ALKALOIDS Sophora alopecuroides X-ray diffraction ANTI-PROLIFERATIVE Apoptosis 
Synthesis and biological evaluation of nitric oxide-releasing matrine derivatives as anticancer agents被引量：6
《Chinese Chemical Letters》2010年第4期381-384,共4页He, Li Qin Liu, Jing Yin, Deng Ke Zhang, Yi Hua Wang, Xiao Shan 
A series of furoxan-based nitric oxide-releasing matrine derivatives(10a-f) were synthesized.The biological evaluation showed that compounds 10a,10b,10e and 10f had stronger cytotoxic activities than 5-fluorouracil ag...
关键词：MATRINE FUROXAN Anti-tumor activity HEPG2 
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