AIM:Vincristine is one of the most commonly used chemotherapeutic drugs to treat a variety of malignant diseases,including leukemia and lymphoma.Studies have shown that vincristine cause painful effects,whereas Salvia...
National Natural Science Foundation of China(No.30572260).
Aim The objectives of the present study were to prepare stealthy vincristine plus quinacrine liposomes and evaluate the pharmacokinetics in Sprague-Dawley rats. Methods Anti-resistant stealthy liposomes were prepared ...
This work was supported in part by grants from Outstanding Physician Program of Health Bureau of Shanghai Municipal Government, Shanghai, China.
Background The development of the targeted signal transduction inhibitor STI571 has prompted us to treat chronic myeloid leukemia in different ways. Since STI571 may reverse multidrug-resistance of K562/MDR cells in v...
Project partly supported by the Natural Science Foundation of Guizhou Province (No E-99-2);the Public Health Bureau of Guizhou Province (No G-99-7)
AIM: To investigate whether human peripheral blood hematopoietic progenitor cells (PBPC) modified with human aldehyde dehydrogenase class-3 gene (ALDH-3) and multidrug resistance gene 1 (MDR1) would increase chemother...
Project supported by the National Natural Science Foundation of China, № 39870885.
AIM: To study whether efflux of glutamate (Glu) at blood brain barrier (BBB) was regulated by P-glycopro-tein(P-gp). METHODS: 1) After intracerebral mi-croinjection [3H]Glu 5 min, recoveries were determined in injecte...