Neurons are highly polarized cells with axons reaching over a meter long in adult humans.To survive and maintain their proper function,neurons depend on specific mechanisms that regulate spatiotemporal signaling and m...
Amyotrophic lateral sclerosis is a devastating neurodegenerative disease for which the current treatment approaches remain severely limited.The principal pathological alterations of the disease include the selective d...
This work was NIH(R01NS092466),NSFC(U2004201);Central Plains Thousand People Plan of Henan Province(204200510013);Henan Overseas Expertise Introduction Center for Discipline Innovation(CXJD2021002);Key Special Project of Zhengzhou University Disciplinary Construction(XKZDJC202001)。
Background:The channel-forming protein Pannexin1(Panx1)has been implicated in both human studies and animal models of chronic pain,but the underlying mechanisms remain incompletely understood.Methods:Wild-type(WT,n=24...
supported by the National Key R&D Program of China(2019YFA0906100 and 2019YFA0904200 to Y.J.C.);the Shenzhen Science and Technology Innovation Program(JCYJ20180504165501371 to Y.J.C.);the National Natural Science Foundation of China(32171464 and 81872783 to Y.J.C.),the Prevention and Control of COVID-2019 Research Program in University of Guangdong Province(2020KZDZX1176 to S.Z.);the Shenzhen Basic Research Program(JCYJ20180507182203049 to S.Z.);the Shenzhen Key Laboratory Foundation(ZDSYS20200811143757022 to S.Z.).
Dear Editor,Chimeric antigen receptor T(CAR-T)cells have achieved substantial advances in the treatment of B-cell malignancies.Despite high initial response rates,some patients relapse,characterized by targeted antige...
supported by the National Natural Science Foundation of China(52160013,51768054);Inner Mongolia Autonomous Region"Grassland Talent"Science Fund Program(CYY012057);Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region(NJYT22062);Inner Mongolia Natural Science Foundation(2021LHMS05026);Inner Mongolia University Research Program(2023RCTD018,2023YXXS023,2024YXXS047).
Biomass,heralded as sustainable“green coal”,plays a crucial role in energy conservation and achieving“dual carbon”objectives through clean conversion.This paper reviews advancements in biomass catalytic gasificati...
supported by the National Natural Science Foundation of China(62231001).
The parametric scattering center model of radar tar-get has the advantages of simplicity,sparsity and mechanism relevant,making it widely applied in fields such as radar data compression and rapid generation,radar ima...
supported by the National Key Research and Development Program of China(2022YFC2304100 and 2021YFA1201003).
Viral infectious clones(ICs)serve as robust platforms for studying viral biology and screening antiviral agents using reverse genetics.However,the molecular profiles and complex limitations of human coronaviruses(HCoV...