DESTABILIZATION

作品数：47被引量：110H指数：6
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Pathological axonal enlargement in connection with amyloidosis,lysosome destabilization,and bleeding is a major defect in Alzheimer’s disease
《Neural Regeneration Research》2026年第2期790-799,共10页Hualin Fu Jilong Li Chunlei Zhang Guo Gao Qiqi Ge Xinping Guan Daxiang Cui 
supported by the National Natural Science Foundation of China,No.81472235(to HF);the Shanghai Jiao Tong University Medical and Engineering Project,Nos.YG2021QN53(to HF),YG2017MS71(to HF);the International Cooperation Project of the National Natural Science Foundation of China,No.82020108017(to DC);the Innovation Group Project of the National Natural Science Foundation of China,No.81921002(to DC).
Alzheimer’s disease is a multi-amyloidosis disease characterized by amyloid-βdeposits in brain blood vessels,microaneurysms,and senile plaques.How amyloid-βdeposition affects axon pathology has not been examined ex...
关键词：Alzheimer’s disease amyloid-β AMYLOIDOSIS axonal enlargement hemoglobin hemorrhage lysosome destabilization neuropil thread tau Wallerian degeneration 
Experimental study and prediction method of solid destabilization and production in deep carbonate reservoir during mining
《Journal of Rock Mechanics and Geotechnical Engineering》2025年第2期1085-1101,共17页Bo Zhou Changyin Dong Fansheng Huang Dongyu Xue Haobin Bai Guolong Li 
financially supported by the National Natural Science Foundation of China(Grant No.52074331).
Wellbore instability is one of the significant challenges in the drilling engineering and during the development of carbonate reservoirs,especially with open-hole completion.The problems of wellbore instability such a...
关键词：Sand production Wellbore stability Carbonate reservoir Prediction method 
Stable hydrogen storage of lithium borohydrides via the catalytic effect of Ni_(2)B induced by thermodynamic destabilization reaction
《Journal of Materials Science & Technology》2024年第35期192-200,共9页Yukun Liu Wei Chen Shunlong Ju Xuebin Yu Guanglin Xia 
supported by the National Key R&D Program of China(No.2021YFB3802400);the National Natural Sci-ence Foundation of China(Nos.22279020,22109026,51971065,51901045,U2130208,and 52071156);the Science and Technology Commission of Shanghai Municipality(Nos.21ZR1407500 and 23ZR1406500).
Lithium borohydride(LiBH_(4))is regarded as a potential hydrogen storage material due to its high gravi-metric and volumetric capacity,but its practical application suffers from high operating temperature and poor rev...
关键词：Hydrogen storage Lithium borohydride Thermodynamic destabilization reaction Catalytic effect REVERSIBILITY 
Activation of stress-response genes by retrograde signaling-mediated destabilization of nuclear importin IMPα-9 and its interactor TPR2被引量：1
《Molecular Plant》2024年第6期884-899,共16页Liping Zeng Maria Fernanda Gomez Mendez Jingzhe Guo Jishan Jiang Bailong Zhang Hao Chen Brandon Le Haiyan Ke Katayoon Dehesh 
supported by National Institutes of Health National Institutes of Health(NIH)R01GM107311-8;National Science Foundation National Science Foundation(NSF)2104365 grants;by Dr.John W.Leibacher and Mrs.Kathy Cookson endowed chair funds to K.D.
Stress-induced retrograde signal transmission from the plastids to the nucleus has long puzzled plant biologists.To address this,we performed a suppressor screen of the ceh1 mutant,which contains elevated 2-C-methyl-d...
关键词：plastidial retrograde signal MEcPP ASK1 impα-9 TPR2 
Lysosomal destabilization:A missing link between pathological calcification and osteoarthritis被引量：1
《Bioactive Materials》2024年第4期37-50,共14页Tao Ye Chenyu Wang Jianfei Yan Zixuan Qin Wenpin Qin Yuxuan Ma Qianqian Wan Weicheng Lu Mian Zhang Franklin R.Tay Kai Jiao Lina Niu 
supported by National Natural Science Foundation of China(82001072,81870805,82170978);National Key R&D Program of China(2022YFC2405900,2022YFC2405901);the Shaanxi Key Scientific and Technological Innovation Team(2020TD-033).
Calcification of cartilage by hydroxyapatite is a hallmark of osteoarthritis and its deposition strongly correlates with the severity of osteoarthritis.However,no effective strategies are available to date on the prev...
关键词：OSTEOARTHRITIS Hydroxyapatite Lysosomal destabilization Chondrocyte pyroptosis Pathological calcification 
Reactive destabilization and bidirectional catalyzation for reversible hydrogen storage of LiBH_(4) by novel waxberry-like nano-additive assembled from ultrafine Fe_(3)O_(4) particles被引量：1
《Journal of Materials Science & Technology》2024年第6期63-71,共9页S.Wang M.H.Wu Y.Y.Zhu Z.L.Li Y.X.Yang Y.Z.Li H.F.Liu M.X.Gao 
supported by the National Natural Science Foundation of China(No.52071287);the Natural Science Foundation of Zhejiang Province(No.LZ23E010002);the Basic and Applied Basic Research Foundation of Guangdong Province(Nos.2021A1515110676,2022A1515011832).
LiBH_(4) containing 18.5 wt.%H_(2) is an attractive high-capacity hydrogen storage material,however,it suffers from high operation temperature and poor reversibility.Herein,a novel and low-cost bifunctional additive,w...
关键词：LiBH_(4) Hydrogen storage Waxberry-like Fe_(3)O_(4) DESTABILIZATION Catalysis 
On the mechanism of Si-promoted destabilization of TiC_(x)particles in Al alloys被引量：1
《Journal of Materials Science & Technology》2023年第34期17-26,共10页H.Dong Y.C.Guo Y.Z.Chen F.Xia Q.Q.Guo Q.Chen G.L.Li J.Y.Zhao Y.Zhong J.P.Li 
the financial supported from the Key R&D Program of Shaanxi Province,China(No.2020ZDLGY13-01);the innovation team program of material developing and application of key engine components(No.K20220185);the National Natural Science Foundation of China(Nos.52101049,52234009 and 52071262).
TiC_(x)is an excellent composite strengthening particle and grain refiner for Al alloys.However,the stability of TiC_(x)is poor when solute Si exists in Al alloy melts,which significantly depresses its strengthening a...
关键词：Al-Si alloy TiC_(x)particles DESTABILIZATION First principles calculations Thermodynamics 
Destabilization of HIF-1a by Diabetes, Oxidative Stress, Obesity and Other Related Disorders
《Journal of Diabetes Mellitus》2023年第2期142-162,共21页Angelos Karavasilis Petros Karkalousos Maria Trapali Christina Fountzoula George Albert Karikas 
One of the most fundamental molecular processes in response to hypoxia is the activation and stabilization of a transcriptional factor called hypoxia induced factor 1a (HIF-1a), which is responsible for the regulation...
关键词：HIF-1A DIABETES Oxidative Stress OBESITY Cancer Angiogenesis Mitochondria 
Seismicity modulation by external stress perturbations in plate boundary vs.stable plate interior
《Geoscience Frontiers》2022年第3期53-67,共15页Batakrushna Senapati Bhaskar Kundu Shuanggen Jin 
supported by the NITR research fellowship;financially supported by the Ministry of Earth Sciences (Seismology Division), Govt. of India, through grant number (MoES/P.O(Seismo)/1(349)/2018) to Bhaskar Kundu
Characterization of critically stressed seismogenic fault systems in diverse tectonic settings can be used to explore the stress/frictional condition of faults,along with its sensitivity for seismicity modulation by p...
关键词：Seismicity modulation Resonance destabilization Plate boundary Stable plate interior 
Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal被引量：1
《Journal of Pharmaceutical Analysis》2021年第5期617-627,共11页Xiaofen Huang Yike Li Meifeng Nie Mingxi Yue Yufang Li Zhijie Lin Huirong Pan Mujin Fang Ting Wu Shaowei Li Jun Zhang Ningshao Xia Qinjian Zhao 
Thisworkwas funded by the National Natural Science Foundation of China(Grant Nos.:81993149041,and U1705283);the National Science and Technology Major Project,China(Project No.:2018ZX09303005-002);Fujian Health Education Joint Research Project,China(Project No.:2019-WJ-05);Xiamen Science and Technology Major Project,China(Project No.:3502Z20193009).
Thimerosal has been widely used as a preservative in drug and vaccine products for decades.Due to the strong propensity to modify thiols in proteins,conformational changes could occur due to covalent bond formation be...
关键词：Thiol-modifying agent Monoclonal antibody Antigenicity loss Epitope-specific Conformational stability 
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