NUCLEUS

作品数:813被引量:803H指数:11
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相关领域:理学医药卫生更多>>
相关作者:阳富民乔永强包洪亮陈发堂单革更多>>
相关机构:华中科技大学重庆邮电大学中国科学院解放军信息工程大学更多>>
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Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2 infection被引量:5
《Zoological Research》2022年第6期1041-1062,共22页Qiang Ma Wenji Ma Tian-Zhang Song Zhaobo Wu Zeyuan Liu Zhenxiang Hu Jian-Bao Han Ling Xu Bo Zeng Bosong Wang Yinuo Sun Dan-Dan Yu Qian Wu Yong-Gang Yao Yong-Tang Zheng Xiaoqun Wang 
supported by the National Basic Research Program of China(2020YFA0804000,2020YFC0842000,2020YFA0112200,2021YFC2301703);Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32010100);Special Associate Research Program of the Chinese Academy of Sciences(E1290601);National Natural Science Foundation of China(32122037,81891001,32192411,32100512,U1902215);Collaborative Research Fund of the Chinese Institute for Brain Research,Beijing(2020-NKX-PT-03);CAS Project for Young Scientists in Basic Research(YSBR-013);Young Elite Scientist Sponsorship Program by the China Association for Science and Technology(2020QNRC001);National Resource Center for Non-Human Primates;。
Infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) causes diverse clinical manifestations and tissue injuries in multiple organs.However, cellular and molecular understanding of SARS-CoV-2 infe...
关键词:SARS-CoV-2 Rhesus macaque Animal model Single-nucleus RNA sequencing Antiviral immune defects Multiple organs 
AoATG5 plays pleiotropic roles in vegetative growth,cell nucleus development,conidiation,and virulence in the nematode-trapping fungus Arthrobotrys oligospora被引量:2
《Science China(Life Sciences)》2022年第2期412-425,共14页Duanxu Zhou Yingmei Zhu Na Bai Le Yang Meihua Xie Jiangliu Yang Meichen Zhu Ke-Qin Zhang Jinkui Yang 
the National Natural Science Foundation of China(31960556 and U1402265);the Applied Basic Research Foundation of Yunnan Province(202001BB050004);the National Basic Research Program of China(2013CB127503)。
Autophagy is an evolutionarily conserved process in eukaryotes,which is regulated by autophagy-related genes(ATGs).Arthrobotrys oligospora is a representative species of nematode-trapping(NT)fungi that can produce spe...
关键词:Arthrobotrys oligospora autophagy-related gene AoATG5 phenotypic traits transcriptome analysis SPORULATION cell nucleus development 
Utility of TPP-manufactured biophysical restrictions to probe multiscale cellular dynamics
《Bio-Design and Manufacturing》2021年第4期776-789,共14页Panyu Fei Haibo Ding Yu Duan Xinyi Wang Wei Hu Peng Wu Mengxiao Wei Zhengchun Peng Zhongze Gu Wei Chen 
supported by the National Basic Research Program of China(Nos.2015CB910800 and 2017ZX10203205);the National Natural Science Foundation of China(Nos.31522021,31971237,and 61671308);the National Key Research and Development Program of China(No.2017YFA0700500);the China Postdoctoral Science Foundation(No.2021M690617).
Biophysical restrictions regulate protein diffusion,nucleus deformation,and cell migration,which are all universal and important processes for cells to perform their biological functions.However,current technologies a...
关键词:Micro-fence Multiscale Protein diffusion Nucleus mechanical bending Cell-climbing ability 
The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry被引量:2
《Signal Transduction and Targeted Therapy》2021年第12期3666-3683,共18页Xujun Liu Wenzhe Si Lin He Jianguo Yang Yani Peng Jie Ren Xiaoping Liu Tong Jin Huajing Yu Zihan Zhang Xiao Cheng Wenting Zhang Lu Xia Yunchao Huang Yue Wang Shumeng Liu Lin Shan Yu Zhang Xiaohan Yang Haixia Li Jing Liang Luyang Sun Yongfeng Shang 
This work was supported by a grant(2016YFC1302304 to Y.S.)from the Ministry of Science and Technology of China;a grant(Z200020 to L.S.)from the Natural Science Foundation of Beijing;a grant(QNBJ2020-2 to L.S.)from National Program for Support of Top-notch Young Professionals;grants(81530073 and 81730079 to Y.S.,31571340 and 81874158 to L.S.,81972659 to W.S.)from the National Natural Science Foundation of China.
The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid(TCA)cycle that are engaged in epigenetic regulation of the chromatin function in the nucleus raise an outstanding question...
关键词:METABOLIC cycle TOGETHER 
Multi-quasiparticle excitations and the impact of the high-j intruder orbital in the N=51^93 Mo nucleus被引量:1
《Chinese Physics C》2021年第1期208-214,共7页Hao Wang Ke-Yan Ma Yi-Heng Wu Yi-Feng Lv Hao-Nan Pan Jing-Bin Lu 
Supported by the National Natural Science Foundation of China (11775098,U1867210,11405072);Jilin Scientific and Technological Development Programs(20190201137JC,20180520195JH);the 13th Five-Year Plan of Scientific Research of Jilin Province (JJKH20180117KJ);China Postdoctoral Science Foundation(2015M571354,2013M541285);the National Basic Research Programme of China (2007CB815005);the Fundamental Research Funds for the Central Universities;the Graduate Innovation Fund of Jilin University。
The level structures of 93 Mo are investigated using Large Scale Shell Model calculations,and reasonable agreement is obtained between the experimental and calculated values.The calculated results show that the lower-...
关键词:level structure shell model multi-particle excitation MO 
An optical brain-to-brain interface supports rapid information transmission for precise locomotion control被引量:6
《Science China(Life Sciences)》2020年第6期875-885,共11页Lihui Lu Ruiyu Wang Minmin Luo 
Ministry of Science and Technology of China (2015BAI08B02);the National Natural Science Foundation of China (91432114 and 91632302);the Beijing Municipal Government。
Brain-to-brain interfaces(BtBIs) hold exciting potentials for direct communication between individual brains. However,technical challenges often limit their performance in rapid information transfer. Here, we demonstr...
关键词:brain-to-brain interface locomotion nucleus incertus fiber photometry OPTOGENETICS support vector machine(SVM)classifier 
Early-life stress alters sleep structure and the excitatory-inhibitory balance in the nucleus accumbens in aged mice
《Chinese Medical Journal》2019年第13期1582-1590,共9页Ting Wang Hong-Li Wang Rui Liu Han Wang Yue Zhang Ya-Xin Sun Yun-Ai Su Tian-Mei Si Ji-Tao Li 
grants from the National Key Basic Research Program of China(973 program,No.2015CB856401);the National Natural Science Foundation of China(Nos.81630031,81571321,and 81571312);the Peking University Medicine Seed Fund for Interdisciplinary Research(No.BMU2017MX021);the Beijing Brain Project(No.Z171100000117016).
Background:Exposure to adverse experiences in early life may profoundly reshape the neurodevelopmental trajectories of the brain and lead to long-lasting behavioral and neural alterations.One deleterious effect of ear...
关键词:Early-life stress SLEEP Aging NUCLEUS ACCUMBENS Mice 
Hoechst-naphthalimide dyad with dual emissions as specific and ratiometric sensor for nucleus DNA damage
《Chinese Chemical Letters》2017年第10期2019-2022,共4页Fu Yang Chao Wang Lu Wang Zhi-Wei Ye Xin-Bo Song Yi Xiao 
supported by the National Natural Science Foundation of China (Nos. 21376038, 21421005 and 21576040);National Basic Research Program of China (No. 2013CB733702)
A ratiometric fluorescent sensor(Hoe-NI) was developed by connecting a nucleus targeted Hoechst unit to a naphthalimide dye via "click chemistry". The sensor achieves high specific nucleus labeling with wash-free ...
关键词:DNA damage Ratiometric sensor Fluorescenct imaging Nucleus labeling NAPHTHALIMIDE 
1-3 Nuclear Fragmentation Induced by Pions at theΔ-resonance Energies
《IMP & HIRFL Annual Report》2016年第1期6-7,共2页
National Basic Research Program of China(973 Program)(2014CB845405,2015CB856903),National Natural Science Foundation of China(11675226,11175218,U1332207)。
The pion dynamics is of importance in understanding the transportation process in heavy-ion collisions and in hadron induced reactions,which also contributes other particle production as the main reaction channels,suc...
关键词:transport QUANTUM NUCLEUS GEMINI part PAST HELP code 
Proton and Two-proton Emissions from Proton-rich Nuclei with 10 ≤ Z ≤ 20被引量:3
《原子核物理评论》2016年第2期160-166,共7页林承键 徐新星 王建松 孙立杰 贾会明 杨磊 马朋 马军兵 杨彦云 金仕纶 黄美容 白真 吴振东 杨峰 胡正国 王猛 雷相国 张焕乔 徐瑚珊 肖国青 
National Basic Research Program of China(973 Program)(2013CB834404);National Natural Science Foundation of China(10735100,10727505,11005156,U1432246,U1432127)
Proton(p) and two-proton(2p) emissions from the proton-rich nuclei with 10≤Z≤20 have been explored by the in-fight decay and implantation decay methods, respectively, in a series of experiments at the HIRFL-RIBLL fa...
关键词:proton emission two-proton emission proton-proton correlation complete-kinematics measurement implantation decay proton-rich exotic nucleus 
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