PANAXADIOL

作品数：9被引量：23H指数：2
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相关领域：医药卫生更多>>
相关作者：杨柯赵雪俭李大男李杨更多>>
相关机构：白求恩医科大学更多>>
相关期刊：《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《人参研究》更多>>
相关基金：国家自然科学基金更多>>
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Network pharmacology and in vivo study:Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis
《World Journal of Gastroenterology》2025年第9期83-99,共17页Yan Qin Rui-Ya Zhang Yu Zhang Yi-Qing Zhao Hai-Feng Hao Jun-Ping Wang 
Supported by Provincial Key Cultivation Laboratory for Digestive Disease Research,Shanxi Province’s“Si Ge Yi Pi”Science and Technology Driven Medical Innovation Project,No.2021SYS13,No.2020SYS13 and No.2021MX03.
BACKGROUND Ulcerative colitis(UC),a chronic and challenging condition,necessitates the development of more effective treatments owing to the unsatisfactory efficacy and side effects associated with current medications...
关键词：Ulcerative colitis Panax ginseng Network pharmacology PANAXADIOL MAPK NF-κB AMPK NRF2 
Ginseng-derived panaxadiol ameliorates STZ-induced type 1 diabetes through inhibiting RORγ/IL-17A axis
《Acta Pharmacologica Sinica》2023年第6期1217-1226,共10页Si-yu Tian Shu-ming Chen Yong-yi Feng Jia-ling He Yong Li 
supported by grants from the National Natural Science Foundation of China(31770814).
Retinoic-acid-receptor-related orphan receptorγ(RORγ)is a major transcription factor for proinflammatory IL-17A production.Here,we revealed that the RORγdeficiency protects mice from STZ-induced Type 1 diabetes(T1D...
关键词：RORγ crystal structure drug discovery inverse agonist PANAXADIOL 
Panaxdiol Saponins Component Promotes Hematopoiesis and Modulates T Lymphocyte Dysregulation in Aplastic Anemia Model Mice被引量：13
《Chinese Journal of Integrative Medicine》2019年第12期902-910,共9页ZHENG Zhi-yin YU Xiao-ling DAI Tie-ying YIN Li-ming ZHAO Yan-na XU Min ZHUANG Hai-feng Chong Beng Hock GAO Rui-lan 
Supported by the National Natural Science Foundation of China(No.81774068);Medical and Health Key Project of Zhejiang Province(No.2011ZDA021);Zhejiang Provincial Natural Science Foundation of China(No.LY14H280004)
Objective: To investigate the potential efficacy of panaxadiol saponins component(PDS-C) in the treatment of aplastic anemia(AA) model mice. Methods: Totally 70 mice were divided into 7 groups as follows: normal, mode...
关键词：PANAXADIOL SAPONINS COMPONENT APLASTIC anemia HEMATOPOIESIS T lymphocyte 
Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity
《Chinese Chemical Letters》2015年第3期334-338,共5页Yan Wu Wei-Qi Chen Yu-Qing Zhao Hu-Ri Piao 
supported by the National Natural Science Foundation of China (Nos.81160381 and 81260468);the Natural Science Foundation of Jilin Province (No.201115235)
An efficient method has been developed for the synthesis of a series of（20R）-panaxadiol derivatives（4a–w） using a continuous-flow microreactor.The antitumor activities of the newly synthesized compounds were eval...
关键词：antitumor adenocarcinoma toward silica batch shorter spectrometer incubated equiv acetate 
Panaxadiol and Panaxatriol Derivatives as Anti-Hepatitis B Virus Inhibitors
《Natural Products and Bioprospecting》2014年第3期163-174,共12页Hao Chen Li-Jun Wang Yun-Bao Ma Xiao-Yan Huang Chang-An Geng Xue-Mei Zhang Ji-Jun Chen 
the National Natural Science Foundation of China for Distinguished Young Scholars(No.81025023);the National Natural Science Foundation of China(81202436);the West Light Foundation of the Chinese Academy of Sciences,and the Youth Innovation Promotion Association,CAS.
28 Derivatives of panaxadiol(PD)and panaxatriol were synthesized and evaluated for their anti-HBV activity on HepG 2.2.15 cells,of which 17 derivatives inhibited HBV DNA replication.Compounds 4,9,10,14,and 15 showed m...
关键词：Chemical modification Panaxadiol and panaxatriol derivatives Anti-HBV activity Structure-activity relationships 
A new panaxadiol from the acid hydrolysate of Panax ginseng被引量：7
《Chinese Chemical Letters》2009年第6期687-689,共3页Li Na Tao Qin Meng Jian Yuan Yin Rui Xing Hao Ran Guo 
supported by Changchun Science and Technology Program Project(No.08YJ41)
A new panaxadiol （compound 1） was obtained from the acid hydrolysate of the total ginsenosides of Panax ginseng C. A. Meyer （Araliaceae）. On the basis of spectroscopic data and single-crystal X-ray diffraction dat...
关键词：Panax ginseng GINSENOSIDE Acid hydrolysate 
Synthesis and Primary Research on Antitumor Activity of Three New Panaxadiol Fatty Acid Esters被引量：2
《Chemical Research in Chinese Universities》2007年第2期176-182,共7页ZHANG Chun-hong LI Xiang-gao GAO Yu-gang ZHANG Lian-xue FU Xue-qi 
the National Natural Science Foundation of China(No 30370159)
For making use of Ginseng resources that exhibit an antitumor activity and for finding new anticancer drugs, three new fatty acid ester compounds： 3/β-acetoxy panaxadiol （ Ⅰ ）, 3β-palmitic acid aceloxy panaxadi...
关键词：SYNTHESIS Panaxadiol fatty acid esters Anti-tumor activity 
人参二醇组皂甙对游泳训练大鼠血清睾酮和睾丸血管紧张素转换酶活性的影响被引量：1
《人参研究》1999年第3期32-35,共4页李大男 杨柯 李峰 韩峰 李杨 赵雪俭 
目的:观察人参二醇组皂甙(Panaxadiol Saponins PDS),对游泳训练大鼠血清睾酮和血管紧张素转换酶(ACE)活性的影响。方法:灌服不同剂量PDS的大鼠经6周递增负荷,流动水游泳训练后,放免法测定其血清睾酮;紫外分光光度法测定睾丸ACE活性。结...
关键词：运动 人参二醇组皂甙(Panaxadiol SAPONINS PDS) 血管紧张素转换酶 睾酮 
不同生长年限的家参质量气相色谱评价方法的研究
《丹东师专学报》1999年第01X期51-53,共3页许天钧 
本文针对丹东地区家参质量的气相色谱评价方法进行研究。对人参中的主要作用成份达玛烷型皂甙的主要水解产物人参三醇和人参二醇在一定的气相色谱条件下进行分析检测。并对人参的鲜样和干样进行提取比较。
关键词：达玛烷型皂甙(Damarane) 人参三醇(Panaxatriol) 人参二醇(Panaxadiol) 气相色谱检测 索氏提取 乙醚多次提取 
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