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pH-sensitive Nanoparticles for High Loading and Efficient Delivery of Doxorubicin被引量：1: 《Journal of Wuhan University of Technology(Materials Science)》2023年第4期929-937,共9页鲁孟丽黄丽华 ZHAN Siwen LI Juncan QIU Tong YANG Mengjia LI Jie TONG Miao ZHANG Xueqiong 施川; Funded by the Industrial Technology Research Institute of Hubei Provincial Department of Science and Technology(No.2020DEB012);the Hubei Provincial Department of Science and Technology Support Enterprise Technology Innovation Development Project(No.2021BAB119)。; An acid-sensitive delivery system based on acylhydrazone bond was developed for high loading and efficient delivery of doxorubicin.Doxorubicin(DOX)was covalently combined with dihydrazide adipate to form acid-sensitiv...; 关键词：NANOPARTICLES acylhydrazone bond polymeric prodrug acid-sensitive

A simple strategy for constructing acylhydrazone photochromic system with visible color/emission change and its application in photo-patterning被引量：2: 《Chinese Chemical Letters》2020年第12期3271-3275,共5页Yuanyuan Liu Qiuchen Peng Yuanyuan Li Hongwei Hou Kai Li; the National Natural Science Foundation of China(Nos.U1904172,21501150,51502079 and 21671174);Key Scientific and Technological Project of Henan Province(No.202102310006)。; As a potential photochromic system,acylhydrazones exhibit many outstanding adva ntages including low cost,simple synthesis and high modifiability compared with some classic photochromic systems.However,the absorption ...; 关键词：PHOTOCHROMISM ACYLHYDRAZONE Rhodamine6G E/Z isomerization Photo-patternin

Synthesis, Crystal Structures, and Binding Behaviors with CT-DNA/BSA, Antimicrobial and Cytotoxic Activities of Three New Pyrazine Acylhydrazones: 《Chinese Journal of Structural Chemistry》2020年第9期1639-1654,1555,共17页YANG Jie LIU Xiang-Rong LIAO Geng-Hui YU Ming-Kun YANG Zai-Wen ZHAO Shun-Sheng; supported by the National Natural Science Foundation of China(Nos.U1903033,21073139 and 21373158);Science and Technology on Combustion and Explosion Laboratory Foundation of Shaanxi(No.6142603010301)。; Three new acylhydrazones containing pyrazine ring(C12H11N5O2·CH3COOH,1;C13H13N5O·2CH3COOH,2;C13H13N5O3·C13H13N5O3,3)were synthesized and fully characterized.The single-crystal XRD indicated that both 1 and 2 crysta...; 关键词：ACYLHYDRAZONE crystal structure CT-DNA/BSA binding antimicrobial activity cytotoxic activity

Crystal Structures, ct-DNA/BSA Binding Properties and Antibacterial Activities of Halogenated Pyridyl Hydrazones: 《Chinese Journal of Structural Chemistry》2020年第3期467-484,377,共19页LIAO Geng-Hui LIU Xiang-Rong ZHAO Shun-Sheng YANG Zai-Wen YANG Zheng; supported by the National Natural Science Foundation of China(Nos.21073139 and 21373158);Science and Technology on Combustion and Explosion Laboratory Foundation of Shaanxi(No.6142603010301)。; Three new halogenated pyridyl hydrazones, namely 4-chlorobenzaldehyde-4-chloropyridine-2-formyl acylhydrazone(C(13)H9Cl2N3O, 3 a), 4-bromobenzaldehyde-4-chloropyridine-2-formyl acylhydrazone(C(13)H9BrClN3O, 3 b) and 4...; 关键词：ACYLHYDRAZONE crystal structure thermal stability CT-DNA BSA antibacterial activity

A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo被引量：1: 《Acta Pharmacologica Sinica》2019年第2期160-169,共10页Hong-xuan Feng Chun-pu Li Shuang-jie Shu Hong Liu Hai-yan Zhang; National Natural Science Foundation of China (No 81522045,31400932,8160297.5).; There is an urgent need to develop effective therapies for ischemic stroke, but the complicated pathological processes after ischemia make doing so difficult. In the current study, we identified a novel diaryl acylhyd...; 关键词：ischemic stroke NEUROPROTECTION diaryl ACYLHYDRAZONE oxygen glucose DEPRIVATION middle cerebral artery occlusion protein KINASE B EXTRACELLULAR SIGNAL-REGULATED KINASE

The visible light responsive properties of organogel based on anthracene-substituted acylhydrazone derivative: 《Chinese Chemical Letters》2018年第3期497-500,共4页Mingang Zhang Dan Wang Binglian Bai Haitao Wang Lihong He Min Li; supported by the Natural Science Foundation of Jilin Province(No. 20170101112JC);Project 985-Automotive Engineering of Jilin University; Aggregation-induced emission-active 4-（3,4,5-bis（octyloxy）phenyl-9-anthracene acylhydrazone （AHP- T8） has been designed and synthesized, and the photo-responsive properties of organogel and xerogel irradiated by ...; 关键词：Organogel Anthracene Photoresponse Aggregation-induced emission Photoisomerization

Crystal Structures,Thermal Behaviors and Biological Activities of Acylhydrazone Compounds Containing Pyrazine Rings and Halogen Atoms被引量：3: 《Chinese Journal of Structural Chemistry》2018年第2期248-261,共14页杨杰刘向荣岳无思杨再文赵顺省杨征; supported by the National Natural Science Foundation of China(Nos.21073139,21103135 and 21301139); Three new kinds of acylhydrazone compounds （C12H10FN5O？H2O, 1; C12H10ClN5O？2CH3COOH, 2; C12H10BrN5O, 3） were synthesized by the reaction of 2-amino-3- pyrazinecarbohydrazide （C5H7N5O） with halogenated benzaldehy...; 关键词：ACYLHYDRAZONE crystal structure CT-DNA/BSA antibacterial activities anticancer

A Photo-Responsive Organogel Based on Pyrene-Substituted Acylhydrazone Derivative: 《Chinese Journal of Chemistry》2017年第12期1829-1834,共6页Qing Chai Jue Wei Binglian Bai Haitao Wang Min Li; Supporting information for this article is available on the WWW under http：//dx.doi.org/10.1002/cjoc.201700388 or from the author.Acknowledgement This work was supported by the Natural Science Foundation of Jilin Province （20170101112JC） and Project 985-Automotive Engineering of Jilin University.; A new simple pyrene-substituted acylhydrazone derivative, 4-（3,4-dioctyloxy） phenyl-l-pyrene acylhydrazone （PAH-8）, was designed and synthesized. The PAH-8 can form thermo-reversible organogel in DMSO, and shows g...; 关键词：PYRENE ORGANOGEL fluorescence fiber PHOTOISOMERIZATION

Syntheses and Crystal Structures of Hg(Ⅱ)and Ag(Ⅰ)Complexes Containing 2-Acetylpyridine-paminobenzoylhydrazone Ligand被引量：2: 《Chinese Journal of Structural Chemistry》2017年第3期471-477,共7页黄超陈冬梅朱必学; Supported by the National Natural Science Foundation of China(No.21061003); The two complexes [HgI_2L]（DMF）（1） and [AgL_2]（ClO_4）（CH_3CN）（2） were synthesized from the reaction of Schiff base ligand（2-acetylpyridine-p-aminobenzoylhydrazone）（L） with HgI_2 or AgClO_4 respectively. ...; 关键词：Schiff base acylhydrazone complex crystal structure

Design,synthesis and biological evaluation of acylhydrazone derivatives as PI3K inhibitors被引量：4: 《Chinese Chemical Letters》2015年第1期118-120,共3页Guo-Rui Gao Jia-Li Liu De-Sheng Mei Jian Ding Ling-Hua Meng Wen-Hu Duan; the National Natural Science Foundation of China(Nos.81273365 and 81321092);Chinese National Science&Technology Major Project "Key New Drug Creation and Manufacturing Program"(Nos.2012ZX09103101-024 and 2014ZX09304002-008-001);Chinese National Programs for High Technology Research and Development(No.2012AA020302);the Shanghai Science and Technology Commission(Nos.11431921100 and 12DZ1930802)for their financial support; Since the PI3K signaling pathway is the most commonly activated in human cancers,inhibition of PI3K is a promising approach to cancer therapy.In this study,a series of 2-methyl-5-nitrobenzeneacylhydrazones were design...; 关键词：PI3K INHIBITOR Aclhydrazone

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