云南高校图书馆联盟文献共享服务平台- SIGNAL-REGULATED

SIGNAL-REGULATED: 作品数：24被引量：108H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：丁宁杨利娟张波夏亚一闫峰更多>>; 相关机构：南方医科大学焦作市第二人民医院兰州大学第二医院杭州赫贝科技有限公司更多>>; 相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Journal of Biomedical Research》《Neural Regeneration Research》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划博士科研启动基金甘肃省自然科学基金更多>>

Roles of extra-cellular signal-regulated protein kinase 5 signaling pathway in the development of spinal cord injury被引量：2: 《Chinese Medical Journal》2019年第21期2601-2611,共11页Chen-Jun Liu Hai-Ying Liu Zhen-Qi Zhu Yuan-Yuan Zhang Kai-Feng Wang Wei-Wei Xia; Background:In consideration of characteristics and functions,extra-cellular signal-regulated protein kinase 5(ERK5)signaling pathway could be a new target for spinal cord injury(SCI)treatment.Our study aimed to evalua...; 关键词：EXTRACELLULAR SIGNAL-REGULATED PROTEIN KINASE 5 MITOGEN activated PROTEIN KINASE Spinal CORD injury Nuclear factor-κB Apoptosis

TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts被引量：3: 《Neural Regeneration Research》2019年第10期1765-1771,共7页Mei-Ge Zheng Wen-Yuan Sui Zhen-Dan He Yan Liu Yu-Lin Huang Shu-Hua Mu Xin-Zhong Xu Ji-Sen Zhang Jun-Le Qu Jian Zhang Dong Wang; supported by the National Natural Science Foundation of China,No.81372041(to DW),and No.81801220(to MGZ); We previously demonstrated that overexpression of tropomyosin receptor kinase A(TrkA)promotes the survival and Schwann celllike differentiation of bone marrow stromal stem cells in nerve grafts,thereby enhancing the r...; 关键词：NERVE REGENERATION bone marrow stromal stem cells TROPOMYOSIN RECEPTOR kinase A RECEPTOR LENTIVIRAL vector shRNA extracellular SIGNAL-REGULATED protein kinases 1/2 Bcl-2 NERVE grafts peripheral NERVE REGENERATION survival neural REGENERATION

Extracts from Huangqi(Radix Astragali Mongoliciplus) and Ezhu(Rhizoma Curcumae Phaeocaulis) inhibit Lewis lung carcinoma cell growth in a xenograft mouse model by impairing mitogen-activated protein kinase signaling, vascular endothelial growth factor prod被引量：11: 《Journal of Traditional Chinese Medicine》2019年第4期559-565,共7页Xu Chengyong Wang Yuguo Feng Jian Xu Ran Dou Yongqi; Supported by the National Natural Science Foundation of China(No.81673810); OBJECTIVE: To study the anti-tumor effects of the extracts from Huangqi(Radix Astragali Mongolici)and Ezhu(Rhizoma Curcumae Phaeocaulis) on the growth of Lewis lung carcinoma(LLC) in a xenograft mouse model and to inv...; 关键词：Carcinoma Lewis lung Vascular endothelial cell growth factors EXTRACELLULAR SIGNAL-REGULATED MAP KINASES Angiogenesis Huangqi(Radix Astragali Mongolici) Ezhu(Rhizoma Curcumae Phaeocaulis)

A11, a novel diaryl acylhydrazone derivative, exerts neuroprotection against ischemic injury in vitro and in vivo被引量：1: 《Acta Pharmacologica Sinica》2019年第2期160-169,共10页Hong-xuan Feng Chun-pu Li Shuang-jie Shu Hong Liu Hai-yan Zhang; National Natural Science Foundation of China (No 81522045,31400932,8160297.5).; There is an urgent need to develop effective therapies for ischemic stroke, but the complicated pathological processes after ischemia make doing so difficult. In the current study, we identified a novel diaryl acylhyd...; 关键词：ischemic stroke NEUROPROTECTION diaryl ACYLHYDRAZONE oxygen glucose DEPRIVATION middle cerebral artery occlusion protein KINASE B EXTRACELLULAR SIGNAL-REGULATED KINASE

Arrestin-mediated signaling: Is there a controversy?: 《World Journal of Biological Chemistry》2018年第3期25-35,共11页Vsevolod V Gurevich Eugenia V Gurevich; Supported by National Institutes of Health RO1 grants,No.EY011500;National Institutes of Health R35 grants,No.GM122491;Cornelius Vanderbilt Endowed Chair(Vanderbilt University),No.NS065868(to Gurevich VV)and No.DA030103(to Gurevich EV); The activation of the mitogen-activated protein(MAP) kinases extracellular signal-regulated kinase(ERK)1/2 was traditionally used as a readout of signaling of G protein-coupled receptors(GPCRs) via arrestins, as oppos...; 关键词：G protein-coupled receptors ARRESTIN G protein SIGNALING Extracellular SIGNAL-REGULATED KINASE 1/2 c-Jun N-TERMINAL KINASE 3

Regulating effect of glycyrrhetinic acid on bronchial asthma smooth muscle proliferation and apoptosis as well as inflammatory factor expression through ERK1/2 signaling pathway被引量：20: 《Asian Pacific Journal of Tropical Medicine》2017年第12期1172-1176,共5页Tao Zhang Jia-Yi Liao Li Yu Guo-Sheng Liu; supported by Guangdong Medical Science and Technology Research Fund Project(No:A2017331); Objective: To study the influence of glycyrrhetinic acid(GA) on bronchial asthma(BA)smooth muscle proliferation and apoptosis as well as inflammatory factor expression and its molecular mechanism.Methods: Male SD guin...; 关键词：Bronchial asthma Glycyrrhetinic acid Extracellular signal-regulated kinase 1/2 Apoptosis Inflammatory factors

Relationship of high-risk HPV infection with MEKK3 and NF-κB expression in cervical intraepithelial neoplasia tissue: 《Journal of Hainan Medical University》2017年第5期17-20,共4页Yan-Fei Lu Guo-Qiang Chen Rui Chen; Objective:To study the relationship of high-risk human papilloma virus (HPV) infection with mitogen-activated protein kinase/extracellular signal-regulated kinase 3 (MEKK3) and nuclear factorκB (NF-κB) expression in...; 关键词：Cervical intraepithelial NEOPLASIA HIGH-RISK HPV MITOGEN-ACTIVATED protein kinase/extracellular SIGNAL-REGULATED KINASE 3 Nuclear factorκB

震荡流体剪切力通过ERK5信号通路促进成骨细胞增殖被引量：7: 《中国骨质疏松杂志》2016年第10期1237-1240,1256,共5页张波杨利娟丁宁许田恩郭来威孟会强汪静王翠芳安丽萍马靖琳夏亚一; 国家自然科学基金(81560361);甘肃省自然科学基金(1506RJZA240);兰州大学第二医院院内博士科研基金(ynbskyjj2015-2-9); 目的探讨震荡流体剪切力(oscillatory shear stress,OSS)通过ERK5信号通路在诱导成骨细胞增殖中发挥的作用。方法对成骨MC3T3-E1细胞进行不同的处理,分为正常组、OSS组、XMD8-92组和OSS+XMD8-92组。采用MTT实验分别测定4组细胞的增殖活...; 关键词：震荡流体剪切力 EXTRACELLULAR SIGNAL-REGULATED KINASE 5 成骨细胞增殖

Anti-apoptotic effect of Shudipingchan granule in the substantia nigra of rat models of Parkinson＇s disease被引量：7: 《Neural Regeneration Research》2016年第10期1625-1632,共8页Qing Ye Xiao-lei Yuan Jing He Jie Zhou Can-xingYuan Xu-ming Yang; financially supported by the National Natural Science Foundation of China,No.81302926,30472207;the Major Project of Shanghai Science and Technology Commission of China,No.15401970100;the Shanghai Municipal Commission of Health and Family Planning of China,No.ZY3-RCPY-2-2005; Levodopa is the gold-standard treatment for Parkinson＇s disease. However, although it alleviates the clinical symptoms, it cannot delay the progressive apoptosis of dopaminergic neurons or prevent motor complications...; 关键词：nerve regeneration Parkinson＇s disease LEVODOPA substantia nigra APOPTOSIS Shudipingchan granule extracellular signal-regulatedkinase pathway behavior neural rege eration

Dual-specificity Phosphatase 1 Deficiency Induces Endometrioid Adenocarcinoma Progression via Activation of Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Pathway被引量：2: 《Chinese Medical Journal》2016年第10期1154-1160,共7页Yuan Yang Jing-Yi Zhou Li-Jun Zhao Bao-Rong Gao Xiao-Ping Wan Jian-Liu Wang; Background： Previously, we reported that dual-specificity adenocarcinoma （EEA）. However, the role of DUSP1 medroxyprogesterone （MPA） are still unclear. phosphatase I （DUSPI） was differentially expressed in endo...; 关键词：Dual-specificity Phosphatase 1 Endometrioid Adenocarcinoma MEDROXYPROGESTERONE Phospho-extracellular Signal-regulated Kinase 1/2

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