supported by the National Key Research and Development Program of China(2021YFC2701100);the National Natural Science Foundation of China(81930036,32293230 and 8215008);the Commission for Science and Technology of Shanghai Municipality(20JC1418500 and 20ZR1404800);Project supported by Shanghai Municipal Science and Technology Major Project。
Heparan sulfate proteoglycan 2(HSPG2)gene encodes the matrix protein Perlecan,and genetic inactivation of this gene creates mice that are embryonic lethal with severe neural tube defects(NTDs).We discovered rare genet...
supported by the Science and Technology Innovation Project of Chongqing Education Commission(China)(No.KJCXZD2020021).
Neurexin-3 is primarily localized in the presynaptic membrane and forms complexes with various ligands located in the postsynaptic membrane.Neurexin-3 has important roles in synapse development and synapse functions.N...
This work was supported by the National Key R&D Program of China(2022YFF1000302);by the project of the Knowledge Innovation Program of Wuhan-Basic Research 2022020801010223;by the National Natural Science Foundation of China(Program No.32070807 to J-X.L).
As a copper(Cu)transport ATPase,ATP7A plays an important role in maintaining Cu homeostasis in the body,but the developmental and physiological roles of atp7a in zebrafish embryogenesis are rarely studied.In this stud...
Carboxylesterases are enzymes widely distributed within living organisms. In insects, they have been mainly involved in dietary metabolism and detoxification function. Interestingly, several members of this family cal...