AGONISTS

作品数：139被引量：373H指数：10
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Tumor-responsive covalent organic polymeric nanoparticles enhancing STING activation for cancer immunotherapy
《Chinese Chemical Letters》2025年第3期357-362,共6页Shuang Liang Jianjun Yao Dan Liu Mengli Zhou Yong Cui Zhaohui Wang 
supported by the Beijing Natural Science Foundation(No.Z230021);the National Natural Science Foundation of China(No.52202356);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2021-RC350-001);the CAMS Innovation Fund for Medical Sciences(No.2022-I2M-1-013).
The cyclic guanosine monophosphate-adenosine monophosphate synthase and the stimulator of interferon genes(cGAS-STING)has emerged as a promising target for cancer immunotherapy.However,the development of natural STING...
关键词：IMMUNOTHERAPY Covalent organic polymers Delivery STING agonists NANOPARTICLE 
Synthesis and evaluation of peptide-fentanyl analogue conjugates as dualμ/δ-opioid receptor agonists for the treatment of pain被引量：1
《Chinese Chemical Letters》2022年第8期4107-4110,共4页Jing Li Tao Zhang Jialin Sun Fengxia Ren Hongxin Jia Zixing Yu Jingchao Cheng Weiguo Shi 
Novel peptide-fentanyl analogue conjugates were synthesized by the covalent coupling of carfentanyl derivatives to the C-terminus or N-terminus of the conformationally constrained dermorphin tetrapeptide BVD03 via a c...
关键词：Peptide-small molecule conjugates Dual MOR/DOR agonists Lead compound ANALGESICS Physical dependence 
Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists
《Chinese Chemical Letters》2016年第1期159-162,共4页Jing Huang Bin Guo Wen-Jing Chu Xin Xie Yu-She Yang Xian-Li Zhou 
supported by grants from the National Natural Science Foundation of China (No. 2140222)
GPR40 has emerged as an attractive drug target for the treatment of type 2 diabetes due to its role in the enhancement of insulin secretion with glucose dependency. With the aim to improve the metabolic and safety pro...
关键词：GPR40 ANTI-DIABETIC Agonist Phenylpropionic acid derivative 
The first examples of ilexgenin A hybrids as a new class of multi-potent,anti-platelet agents被引量：2
《Chinese Chemical Letters》2013年第8期723-726,共4页Li-Ping Lin Fei-Hua Wu Jing-Yu Liang 
supported by a grant from the Postgraduate Innovation Project of Jiangsu Province,China(No. CX09B_284Z);the Natural Science Foundation of Jiangsu Province,China(No.BK2012378)
Seventeen novel ilexgenin A hybrids（lA-aspirin） and（IA-NO）,as donor hybrids（IA-NO will release NO in vivo and function as NO donor）,were designed and synthesized in order to develop new multi-targeting agents fo...
关键词：Ilexgenin A Hybrids Multi-potent anti-platelet activity ADP agonists 
Synthesis of urea acetates as potential PPARα/γ dual agonists
《Chinese Chemical Letters》2008年第2期166-168,共3页Chang Yan Zhao Chang Qing Shi Yuan Wei Chen 
In the quest for novel PPARα/γ dual agonists as putative drugs for the treatment of type 2 diabetes and dyslipidemia, we designed and synthesized a series of urea acetates as potential PPARα/γ dual agonists. The s...
关键词：Oxazolc PPAR agonist Type 2 diabetes UREA AMMONOLYSIS Synthesis 
Synthesis of 2-(Benzodioxol-2-yl)acetic Acids as PPARδAgonists
《Chinese Chemical Letters》2006年第8期1013-1016,共4页Jian Lei KANG Zhi Bing ZHENG Dan QIN Li Li WANG Song LI 
supported by the National High Technology Research and Development Program of China(863 project:2003AA235010);the National Natural Science Foundation of China(No.30472092).
A new series of compounds, 2-（benzodioxol-2-yl）acetic acids, have been synthesized. Their structures were confirmed by MS and 1H-NMR. The preliminary pharmacological screening showed that these compounds exhibited p...
关键词：PPARδ agonists 2-（benzodioxol-2-yl）acetic acids synthesis. 
3 D-QSAR Analysis of Agonists of nAChRs: Epibatidine Analogues被引量：1
《Chinese Chemical Letters》2004年第11期1380-1382,共3页HuaBeiZHANG ChunPingLIU 
A 3 D-QSAR about nAChRs agonists-epibatidine analogues was performed using the CoMFA and CoMSIA. The correlation coefficients were R2cv = 0.546, R2ncv = 0.907 in CoMFA and R2cv = 0.655, R2ncv = 0.962 in CoMSIA of the...
关键词：D - QSAR COMFA COMSIA NACHRS agonists. 
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