Objective:To investigate the effect of lipoxin receptor agonist BML-111 on the NLRP3 inflammasome after traumatic brain injury in rats.Methods:Sixty male Sprague-Dawley rats,weighing 280~340 g,were randomly divided in...
funded in part by the North Carolina State University Agricultural Foundation,USDA-NIFA Animal Health Program
Background: Respiratory infections challenge the swine industry, despite common medicinal practices. The dual signaling nature of PGE2(supporting both inflammation and resolution) makes it a potent regulator of immune...
This study was supported by grants from the Innovation Foundation of Health and Family Planning Commission of Hubei Province (No. WJ2017M036) and the National Natural Science Foundation of China (No. 81471858).
The aim of the present study was to investigate the effect of lipoxin A4 (LXA4) pretreatment on cognitive function of aged rats after global cerebral ischemia reperfusion, and to explore its possible mechanism. Thir...
This study examined in vitro effect of lipoxin A 4 (LXA 4) on interleukin-1β (IL-1β) production of monocytes and its possible mechanism in severe preeclampsia (PE).Peripheral venous blood was drawn from 15 patients ...
the grants from the National Nature Science Foundation of China (No. 30570726 and No. 30100226)
Background Lipoxins (LXs), endogenous anti-inflammatory and pro-resolving eicosanoids generated during various inflammatory conditions, have novel immunomodulatory properties. Because dendritic cells (DCs) play cr...
In order to investigate whether lipoxin A4 (LXA4) has an antagonistic effect on lipopolysaccharide (LPS)-induced synthesis of interleukin (IL)-β3, IL-6 and IL-8 in rat pulmonary microvascular endothelial cells ...
Objective: To examine whether lipoxin A4 (LXA4) has an inhibitory effect on tumor necrosis factor-α(TNF-α-induced DNA synthesis of glomerular mesangial cells of rat, and explore the molecular mechanisms of LXA4 ...